Development of alfuzosin gastro resistant prolonged release tablet and evaluate using HPLC
Abstract
Alfuzosin belongs to a class of drugs known as alpha blockers. As an antagonist of the alpha 1 adrenergic receptor, it works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate. Alfuzosin gastro resistant prolonged release tablet was prepared as the prepared tablet will improve the bioavailability as well dosing frequency. The prepared gastro resistant prolonged release tablet was evaluated using HPLC. The release profile of each film coated prolonged release tablet contains Alfuzosin HCl IP. 10 mg was found to be range from 23.27 % to 93.58 % from 1st hour to 20th Hour of the release time. From the above study it was concluded that the prolonged release tablet of alfuzosin was found to be effective for long term therapy.
Keywords: Alfuzosin, Gastro Resistant, Prolonged Release, HPLC
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