PREPARATION, CHARACTERIZATION AND EVALUATION OF NEBIVOLOL LOADED CHITOSAN NANOPARTICLES
Abstract
Nebivolol (NEB) is an antihypertensive drug with poor oral bioavailability (12%) in humans due to extensive first pass hepatic metabolism. Present work is an attempt to improve oral bioavailability of nebivolol by incorporating it with biodegradable polymer chitosan and preparing its nanoparticles. The results indicated stable nanoperticles with the value of ZP to be +36.4 mV ± 2 mV, the small particle size of 79.23 ± 45 nm and high entrapment efficiency of 72.56%. The in vitro release study revealed sustained release of drug for 72 h with 71.24% cumulative drug release. The promising results from the study revealed the applicability of chitosan in the formulation of NEB loaded CNPs.
Keywords:
Nebivolol, chitosan, ionic gelation technique, nanoparticles, oral bioavailability, poor water solubilityDOI
https://doi.org/10.22270/jddt.v8i2.1730References
Whelton P, He J., Appel L. J. Primary prevention of hypertension: Clinical and public health advisory from the National high blood pressure education programme. JAMA. 2002, 288(15), 1882–1888.
Neduri, K.; Bontha, V.K.; Vemula, S.K. Different techniques to enhance the dissolution rate of lovastatin: Formulation and evaluation. Asian Journal of Pharmaceutical and Clinical Research, 2013, 6, 56–60.
Hauss D., Oral lipid-based formulations, Advanced Drug Delivery Reviews, 2007, 59, 557-676.
Grass G. M. and Sinko P. J., Effect of diverse datasets on the predictive capability of ADME model in drug discovery, Drug Discovery Today , 2001,6(12) ,S54 – S61.
Kawashima Y. Nanoparticulate systems for improved drug delivery. 2001, Advanced Drug Delivery Reviews, 47, 1–2.
Musther H. et al., Animal versus human oral drug bioavailability: do they correlate? European Journal of Pharmaceutical Sciences, 2014, 57,280 - 291
Abrahammson B. etal., Extrapolation of Preclinical Data to Predict Human Pharmacokinetics: Understanding and Practice, AAPS Annual Meeting (Los Angeles, California, 2009).
Na Z., Larry L.A., The influence of swelling capacity of super disintegrate in different pH media on the dissolution of hydrochlorothiazide from directly compressed tablets.,AAPS Pharm.Sci.Tech., 2005,6(4),E120- E126.
Ajun W, Yan S, Li G, Huili L., Preparation of aspirin and probucol in combination loaded chitosan nanoparticles and in vitro release study. Carbohydrate Polymers. 2009, 75(4), 566–574.
Dubernet C.,Thermoanalysis of microspheres., Thermochim Acta, 1995,248, 259–269.
Published
Abstract Display: 832 
PDF Downloads: 824 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.