A REVIEW ON CLEANING VALIDATION IN PHARMACEUTICAL INDUSTRY
Abstract
In pharmaceutical industry there are some possibilities of contamination and cross-contamination because of improper cleaning of equipment, apparatus, processing area or the starting material, this can lead to severe hazards, therefore in pharmaceutical industry we can’t afford any contamination as well as cross contamination. This can be minimized by proper cleaning of equipment, apparatus as well as the processing area. TheIndustry wants to achieve these main goals with the help of GMP. This review focused on the different types of cleaning process adapted by pharmaceutical industry, how the process of cleaning validation is done. In the cleaning validation different critical parameter, factor, material and critical process are monitored and validated so that the cleaning consistency can be achieved and documented accordingly.
Keywords: Cleaning validation, contamination, clean in place, clean out of place, swab sampling, worst case
DOI
https://doi.org/10.22270/jddt.v8i3.1695References
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