A REVIEW ON NOVEL APPROACHES FOR ORAL DELIVERY OF INSULIN

Abstract

Objectives: A review article on novel approaches on oral insulin delivery.

Data Sources:  Review articles on oral insulin delivery, Books.

Study selection: This review consist of importance as well as current approaches for oral insulin delivery like liposomes, nanospheres, nanocubeics, erythrocytes, thiolated chitosan tablets, chitosan microspheres etc.

Summary of content article: Type 1 diabetes mellitus is a metabolic disorder which arouse as a major health problem worldwide. Clinical management of insulin is done by insulin replacement therapy and current route of its administration is through subcutaneous injection having many challenges. To overcome the problems associated with insulin injections novel approaches for insulin administration are being explored. If insulin is administered orally, in the stomach rapid enzymatic degradation of insulin occurs and in the intestine insulin is digested and hence inactivated by the action of proteolytic enzymes occurs. This review consist of importance as well as current approaches for oral insulin delivery like liposomes, nanospheres , nanocubeics, erythrocytes, thiolated chitosan tablets, chitosan microspheresetc. This review also gives the information about current market status of oral insulin⁵.

Conclusion: The oral route is considered to be most acceptable and convenient route of administration for chronic therapy. Attempts have been made to achieve oral insulin delivery using various systems. Liposomes, microemulsions, nanocubicles, thiolated chitosan, chitosan microspheres and so forth have been prepared for the oral delivery of insulin.

Keywords: oral insulin, approaches for oral insulin delivery , current market status.