PREPARATION AND EVALUATION OF IRBESARTAN-CYCLODEXTRIN INCLUSION COMPLEXES
Abstract
In the present work effect of methyl-β-cyclodextrin (MβCD) on physical properties and dissolution rate of Irbesartan (IRB) was studied.Based on AL-type ofphase solubility diagram obtained, solid binary systems of the drug with MβCD were prepared in 1:1 molar ratio by various methods. Complexes were characterized using Differential Scanning Calorimetry and powder X-Ray Diffractometry. It could be concluded that IRB can form inclusion complex with MβCD. The dissolution profiles of inclusion complexes were compared with those of IRB alone and the physical mixture. The dissolution rate of IRB was increased remarkably by MβCD inclusion complexation.
DOI
https://doi.org/10.22270/jddt.v7i7.1573References
Irbesartan In: (Ed.), Martindale’s: The complete drug reference, 34rded, Pharmaceutical Press, London, 2004, 34rded,940.
Pouleur HG, A new angiotensin II receptor antagonist, Am J Hyperten, 1997, 10, 318-324.
Beker O, Uijtendaal EV, Beijnen JH, Butt A, Underberg WJM, Cyclodextrins in the pharmaceutical field, Drug Dev Ind Pharm, 1991, 17, 1503-1549.
Higuchi T, Connors KA (1965) In: C. N. Reilly (Ed.), Advances in Analytical Chemistry and Instrumentation, Interscience, New York, pp117-212.
Bandi N, WeiW, Roberts CB, Kotra LP, Kompella UB, Preparation of budesonide- and indomethacin-hydroxypropyl-beta-cyclodextrin (HPBCD) complexes using a single-step, organic-solvent-free supercritical fluid process, EJPS, 2004, 23, 159-168.
Published
Abstract Display: 403 
PDF Downloads: 582 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.