A Review on Finasteride: A 5-Alpha Reductase Inhibitors, its Mechanism, Facts and Benefits

  • Shraddha T. Nemane
  • Omprakash G. Bhusnure
  • Sachin B. Gholve
  • Pooja R. Mitakari
  • Pawan N. Karwa

Abstract

This review gives the information about the Finasteride i.e. 5alpha-reductase inhibitor. Primarily finasteride isused to treat BPH i.e benign prostatic hyperplasia and male androgenetic alopecia. Five-alpha reductase inhibitors (5α-RIs) could stimulate male sexual dysfunction due to their effects on testosterone and DHT i.e. dihydrotestosterone. Some studies account insignificant or acceptable adverse effects, which decrease after a changeable period of time so that they do not require terminating finasteride administration. The 5alpha-reductase inhibitor finasteride blocks the conversion of TT to DHT i.e. testosterone to dihydrotestosterone (DHT), the androgen responsible for androgenetic alopecia i.e. male pattern hair loss. This paper presents a possible explanation of the Finasteride drug.


Keywords: Finasteride, 5alpha-reductase inhibitor, BPH, DHT, alopecia.

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Nemane ST, Bhusnure OG, Gholve SB, Mitakari PR, Karwa PN. A Review on Finasteride: A 5-Alpha Reductase Inhibitors, its Mechanism, Facts and Benefits. JDDT [Internet]. 30Jun.2019 [cited 3Jul.2020];9(3-s):1132-6. Available from: http://jddtonline.info/index.php/jddt/article/view/3013

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