DEVELOPMENT AND EVALUATION OF PRONIOSOMES AS DRUG CARRIERS FOR TRANSDERMAL DELIVERY OF KETOROLAC TROMETHAMINE

  • Nadeem Farooqui Suresh Gyan Vihar University, Mahal Jagatpura, Jaipur (RJ) – India
  • Mousumi Kar IPS Academy College of Pharmacy, Indore (MP) – India
  • Sanjay Jain Indore Institute of Pharmacy (IIP), Indore (MP) – India

Abstract

Ketorolac tromethamine is a drug with narrow therapeutic index and short biological half-life. This study was aimed at developing and optimizing proniosomal formulation of ketorolac tromethamine in order to improve its bioavailability. The prepared proniosomal gel formulations were evaluated and the effect of the varying composition of non ionic surfactant and cholesterol in various formulations were studied, such as vesicle shape, zeta potential, entrapment efficiency, and in- vitro drug release study. The presence of cholesterol made the proniosomes more stable with high drug entrapment efficiency and retention properties. The highest entrapment efficiency was observed with sodium cholate 88.17 ± 0.95 as compared to those formulation prepared with span60 and with sodium deoxycholate. Formulation F1 (LCI-I), zeta potential value was observed -20.0 mV, which is a measure of net charge of proniosomes which made them stable, by preventing aggregation. Formulation   F1 which prepared by sodium cholate,  showed highest drug release of 94.048 % after 24 hrs as compared to formulation F6 (LDCI-3) and F9 (LSI-3) which were prepared by sodium deoxycholate and sapn60 showed lowest drug release of  76.35% and 69.12%.

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Author Biographies

Nadeem Farooqui, Suresh Gyan Vihar University, Mahal Jagatpura, Jaipur (RJ) – India
Suresh Gyan Vihar University, Mahal Jagatpura, Jaipur (RJ) – India
Mousumi Kar, IPS Academy College of Pharmacy, Indore (MP) – India
IPS Academy College of Pharmacy, Indore (MP) – India
Sanjay Jain, Indore Institute of Pharmacy (IIP), Indore (MP) – India
Indore Institute of Pharmacy (IIP), Indore (MP) – India

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How to Cite
Farooqui, N., Kar, M., & Jain, S. (2017). DEVELOPMENT AND EVALUATION OF PRONIOSOMES AS DRUG CARRIERS FOR TRANSDERMAL DELIVERY OF KETOROLAC TROMETHAMINE. Journal of Drug Delivery and Therapeutics, 7(7), 38-40. https://doi.org/10.22270/jddt.v7i7.1580