DEVELOPMENT AND EVALUATION OF PRONIOSOMES AS DRUG CARRIERS FOR TRANSDERMAL DELIVERY OF KETOROLAC TROMETHAMINE
Ketorolac tromethamine is a drug with narrow therapeutic index and short biological half-life. This study was aimed at developing and optimizing proniosomal formulation of ketorolac tromethamine in order to improve its bioavailability. The prepared proniosomal gel formulations were evaluated and the effect of the varying composition of non ionic surfactant and cholesterol in various formulations were studied, such as vesicle shape, zeta potential, entrapment efficiency, and in- vitro drug release study. The presence of cholesterol made the proniosomes more stable with high drug entrapment efficiency and retention properties. The highest entrapment efficiency was observed with sodium cholate 88.17 Â± 0.95 as compared to those formulation prepared with span60 and with sodium deoxycholate. Formulation F1 (LCI-I), zeta potential value was observed -20.0 mV, which is a measure of net charge of proniosomes which made them stable, by preventing aggregation. FormulationÂ Â F1 which prepared by sodium cholate,Â showed highest drug release of 94.048 % after 24 hrs as compared to formulation F6 (LDCI-3) and F9 (LSI-3) which were prepared by sodium deoxycholate and sapn60 showed lowest drug release ofÂ 76.35% and 69.12%.
2. Chen XH, Bai JY, Shen F, Bai AP, Guo ZR, Cheng GF, Imrecoxib: a novel and selective cyclooxygenase 2 inhibitor with anti-inflammatory effect, Acta Pharmacol Sin, 2005, 927-931.
3. Fry DW, White JC, Goldman ID, Rapid separation of low molecular weight solutes from liposomes without dilution, Anal Biochem, 1978, 809-815.
4. El Maghraby GM, Williams AC, Barry BW, Skin delivery of oestradiol from lipid vesicles: importance of liposome structure, Int J Pharm, 2000, 63-74.
5. OzgÃ¼ney IS, Karasulu HY, Kantarc G, SÃ¶zer S, GÃ¼neri T, Ertan G, in vitro release of diclofenac sodium from different topical vehicles, AAPS Pharm Sci Tech, 2006, E1-E7.
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