DEVELOPMENT AND EVALUATION OF BUCCAL DOSAGE FORMS OF GARCINIA CAMBOGIA
Abstract
Medicated jelly formulations are more suitable for pediatric, geriatric and dysphagic patients, which offer rapid dissolution and absorption of drugs thereby early onset of action. The aim of study was to develop and evaluate oral jelly formulation of Garcinia cambogia extract using pectin as the natural gelling agent. The primary objective was formulation of unit moulded jelly containing herbal medicaments and also to optimize the dosage form that will have extra beneficiary for hepatoprotective and weight-loss supplement effect without any side effects. The crude extract or constituents from the plant also exerted hypolipidemic, antidiabetic, anti-inflammatory, anticancer, anthelmintic, anticholinesterase and hepatoprotective activities. All the formulations exhibited good physiochemical properties and found to be stable.
DOI
https://doi.org/10.22270/jddt.v7i7.1591References
Ninomiya H, Shimizu T, Dairaku M, Komagata T, Misawa M, Jellied medicinal composition for oral administration, Unites States Patent, Patent number US 5932235.
Kim MS, Kim JK, Kwon DY, Park R, Anti-adipogenic effects of Garcinia extract on the lipid droplet accumulation and the expression of transcription factor, Biofactors, 2004, 22,193–196.
Kim KY, Lee HN, Kim YJ & Park T, Garcinia cambogia extract ameliorates visceral adiposity in C57BL/6 J mice fed on a high-fat diet, BBB, 2008,72, 1772–1780.
Altiner A, Ates A, Gursel FE & Bilal T, Effect of the antiobesity agent Garcinia cambogia extract on serumlipoprotein (a), apolipoproteins a1 and b, and total cholesterol levels in female rats fed atherogenic diet, JAP, 2012, 22, 872–877.
Rawlins EA, Bentley’s text book of pharmaceutics, Bailleere Tindall, London, 1995, Edition 18:19-24.
Published
Abstract Display: 330 
PDF Downloads: 374 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.