PREPARATION AND EVALUATION OF POLYMERIC NANOPARTICLES OF GLIBENCLAMIDE

Authors

  • Anup Naha Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal- 576104, Karnataka, India
  • Kiran Sai Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal- 576104, Karnataka, India
  • Ikya Rai Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal- 576104, Karnataka, India
  • Bhavisha Vora Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal- 576104, Karnataka, India
  • Apoorva D Reddy Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal- 576104, Karnataka, India
  • P Kartika Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal- 576104, Karnataka, India

Abstract

Simple, reliable and reproducible method was used for the preparation of polymeric nanoparticles of Glibenclamide. The formulation was prepared by solvent evaporation method using magnetic stirrer with overnight stirring and the same was then evaluated for its particle size, drug content and in vitro dissolution studies. The above mentioned method showed similar particle size and exhibited an improvement in the drug entrapment efficiency. The ultraviolet spectrophotometric method was used to analyze Glibenclamide at 300 nm in different buffers. The study demonstrated the successful preparation of sustained release polymeric nanoparticles of Glibenclamide.

Keywords: Glibenclamide, polymeric nanoparticles, solvent evaporation

DOI

https://doi.org/10.22270/jddt.v4i5.982

Published

2014-09-17
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How to Cite

1.
Naha A, Sai K, Rai I, Vora B, Reddy AD, Kartika P. PREPARATION AND EVALUATION OF POLYMERIC NANOPARTICLES OF GLIBENCLAMIDE. J. Drug Delivery Ther. [Internet]. 2014 Sep. 17 [cited 2026 Jan. 21];4(5):190-2. Available from: https://jddtonline.info/index.php/jddt/article/view/982

Issue

Vol. 4 No. 5 (2014): Volume 4, Issue 5, Sep-Oct, 2014

Section

Research

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How to Cite

1.
Naha A, Sai K, Rai I, Vora B, Reddy AD, Kartika P. PREPARATION AND EVALUATION OF POLYMERIC NANOPARTICLES OF GLIBENCLAMIDE. J. Drug Delivery Ther. [Internet]. 2014 Sep. 17 [cited 2026 Jan. 21];4(5):190-2. Available from: https://jddtonline.info/index.php/jddt/article/view/982
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