TASTE MASKING EVALUATION AND FORMULATION OF DICYCLOMINE HYDROCHLORIDE SUSPENSION USING ION EXCHANGE RESINS
There are number of drugs that are bitter and unpleasant in taste and taking orally very difficult for children and some adults. Nonâ€compliance canÂ lead to many problems in diseased condition. There are lots of taste masking technologies have been used to address the problem of patient compliance. The purpose of this research was to mask the intensely bitter taste of Dicyclomine HClÂ and to formulate a palatable liquid formulation of the taste-masked drug, by novel Ion Exchange Resin (IER) method to overcome taste problem with traditional system. Taste masking was done by complexing Dicyclomine HClÂ with Tulsion 335, Indion 254Â and Indion 414 in different ratios. Formulation containing resinates were tested for drug content, in vitro drug release, taste masking, stability study, and molecular property. The resinates prepared with drug- Indion 254 ratio (1:2) at pH 8, gave maximum drug loading. Suspension containing above resinates showed more than 80% In vitro drug release within 30 min. Prepared formulation also showed good stability and can retain its palatable taste. Thus, the â€œpatient-friendly dosage formâ€ of bitter drugs, especially for pediatric, geriatric, bedridden, and noncooperative patients, can be successfully formulated using this technology.Keyword: Taste Masked Suspension, Dicyclomine HCl Taste masking, resinate
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