SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL 1,3,4-OXADIAZOLE BASED DITHIAZA-SPIRONES

  • Mahipal Reddy Yata Department of Chemistry, Kakatiya University, Warangal, Andhra Pradesh 506-009, India
  • Ravi Prasad Talagadadivi Department of Chemistry, Kakatiya University, Warangal, Andhra Pradesh 506-009, India

Abstract

A novel series of  4-phenyl-9-(5-phenyl-[1,3,4-oxadiazol-2-yl)-1,6-dithia-4,9-diaza-spiro-[4.4]-nonane-3,8-diones (4a-e) in good to excellent yields by using commercially available 2-amino-5-phenyl-1,3,4-oxadiazole (1) as raw material and 2-chloro-N-(5-phenyl-[1,3,5]-oxadiazol-2-yl)-acetamide (2) and  2-benzylidene-3-(5-phenyl-[1,3,5]-oxadiazol-2-yl)-thiazolidin-4-onea (3a-e) as intermediates. The chemical structures of these compounds have been established by IR, 1H, 13C-NMR, Mass spectral data and elemental analysis. The newly synthesized compounds were screened for their ability towards antimicrobial activity.

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Yata M, Talagadadivi R. SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL 1,3,4-OXADIAZOLE BASED DITHIAZA-SPIRONES. JDDT [Internet]. 14Jul.2014 [cited 4Dec.2021];4(4):82-5. Available from: https://jddtonline.info/index.php/jddt/article/view/905