Formulation and Evaluation of Floating Oral In-Situ Gel of Etodolac: A Comprehensive Review
Abstract
Etodolac is a non-steroidal anti-inflammatory drug (NSAID) used for the management of pain and inflammatory disorders. Although conventional oral administration provides effective systemic exposure, the relatively short terminal half-life and rapid gastrointestinal transit may necessitate repeated administration and may produce fluctuating drug concentrations. Gastroretective drug delivery systems (GRDDS), particularly floating oral in-situ gels, provide an attractive approach for prolonging gastric residence and regulating drug release. This review and experimental framework focus on the development of a floating oral in-situ gel of etodolac using suitable hydrophilic and ion-responsive polymers. The formulation is designed to remain in the stomach by generating a low-density, gelled structure following contact with gastric fluid. Sodium alginate, gellan gum, hydroxypropyl methylcellulose (HPMC) and suitable gas-generating agents can be investigated to achieve rapid gelation, adequate floating ability, appropriate viscosity and sustained drug release. Important formulation and evaluation parameters include appearance, pH, viscosity, gelation characteristics, floating lag time, total floating duration, drug content, swelling, in-vitro dissolution, release kinetics and stability. Optimization of polymer concentration and polymer combinations is essential because viscosity, gel strength, buoyancy and drug diffusion are interdependent. A well-designed etodolac floating in-situ gel may provide prolonged gastric residence and controlled drug delivery, although in-vivo gastric-retention and pharmacokinetic studies are required to establish its clinical advantage.
Keywords: Etodolac; Floating in-situ gel; Gastroretective drug delivery; Sodium alginate; Sustained release
Keywords:
Etodolac, Floating in-situ gel, Gastroretective drug delivery, Sodium alginate, Sustained releaseDOI
https://doi.org/10.22270/jddt.v16i10.8039References
1. Kumar A, Kumar A. Smart Pharmaceutical Formulations of Biopolymeric Materials in Buccal Drug Delivery. Biomedical Materials & Devices. 2025;3(2):741-749. https://doi.org/10.1007/s44174-024-00223-y
2. Qu W, Wu P, Yang S, Liu T, Qi S, Chen XD. Mechanistic prediction of food-induced variability in drug release and pharmacokinetics using a dynamic gastrointestinal system and convolution-based modeling. Int J Pharm. 2026;701:127107. https://doi.org/10.1016/j.ijpharm.2026.127107 PMid:42320737
3. Singh A, Mandal RK, Sahoo S, Shah TM, Pal R. Gastro-Retentive Drug Delivery Systems (GRDDs) as a Promising Strategy for Disease Targeting: A Comprehensive Review. Drug Deliv Lett. 2026;16. https://doi.org/10.2174/0122103031410778251206145139
4. Shah K, Singh D, Agrawal R, Garg A. Current Developments in the Delivery of Gastro-Retentive Drugs. AAPS PharmSciTech. 2025;26(2):57. https://doi.org/10.1208/s12249-025-03052-4 PMid:39920556
5. Ashraf F, Shah KU, Saeed MD, et al. Non-effervescent Polymeric Floating Tablets of Clarithromycin and Pantoprazole: Preparation and In-Vitro Evaluation for Improved Gastric Drug Retention. J Pharm Innov. 2025;20(1):6. https://doi.org/10.1007/s12247-024-09917-8
6. Mathews MM. Alginate-Based Composites in Drug Delivery. In: Natural Biopolymeric Composites for Biomedical Research. Springer Nature Singapore; 2026:333-350. https://doi.org/10.1007/978-981-95-9909-7_14
7. Toth SH, Stoica AD, Sevcencu C. Redesigning Ibuprofen for Improved Oral Delivery and Reduced Side Effects. Bioconjug Chem. 2025;36(5):893-913. https://doi.org/10.1021/acs.bioconjchem.4c00558 PMid:40292773
8. Sebaa R, AlMalki RH, Sukkarieh H, et al. Systemic Metabolic Alterations Induced by Etodolac in Healthy Individuals. Pharmaceuticals. 2025;18(8):1155. https://doi.org/10.3390/ph18081155 PMid:40872546 PMCid:PMC12388885
9. Dutta P, Dhar A, Dhang P, Mukherjee K, Giri TK. In Situ Gellable Hydrogels for Gastroretentive Drug Delivery Systems. In: In Situ Gellable Hydrogels for Drug Delivery and Tissue Engineering. Springer Nature Singapore; 2026:87-115. https://doi.org/10.1007/978-981-95-6619-8_4
10. Liu G, Jin X, Yang R, Chen N, Sharafat A, Zhang W. Gastric fluid-triggered echogenic hydrogel for long-term ultrasound imaging and drug release. Chemical Engineering Journal. 2025;526:170837. https://doi.org/10.1016/j.cej.2025.170837
11. Gupta S, Agrawal N, Siddiqui MA, Sharma AK, Jain SK, Lanjhiyana SK. Current trends in colon-targeted delivery using microbeads system: approaches, methodologies and therapeutic aspects. Published online August 6, 2026. https://doi.org/10.1007/s43538-026-00859-y
12. Wang C, Chen J, Chen N, et al. Sodium alginate/gelatin/guar gum oral delivery ternary composite hydrogel beads loaded with Anzhong decoction: Gastric floating retention and controlled release. Int J Biol Macromol. 2026;344:150390. https://doi.org/10.1016/j.ijbiomac.2026.150390 PMid:41571133
13. Singh JK, Kaur S, Chandrasekaran B, et al. A QbD-Navigated Approach to the Development and Evaluation of Etodolac-Phospholipid Complex Containing Polymeric Films for Improved Anti-Inflammatory Effect. Polymers (Basel). 2024;16(17):2517. https://doi.org/10.3390/polym16172517 PMid:39274149 PMCid:PMC11398249
14. Bhamble S, Dighe S, Katari O, Yadav V, Ansari MdM, Jain S. Ionic liquid-based Ionogel: A novel strategy to improve dermal delivery and in vivo efficacy of etodolac in rheumatoid arthritis management. J Mol Liq. 2024;412:125841. https://doi.org/10.1016/j.molliq.2024.125841
15. Sánchez-Luquez K, Reis Silveira AM, Sánchez-Vinces S, et al. Etodolac Single Dose Metabolic Profile Elucidation: Pharmacokinetics and Adverse Events in Healthy Volunteers. Pharmaceuticals. 2025;18(1):82. https://doi.org/10.3390/ph18010082 PMid:39861145 PMCid:PMC11768370
16. Basu S, Varghese R, Debroy R, Ramaiah S, Veeraraghavan B, Anbarasu A. Non-steroidal anti-inflammatory drugs ketorolac and etodolac can augment the treatment against pneumococcal meningitis by targeting penicillin-binding proteins. Microb Pathog. 2022;170:105694. https://doi.org/10.1016/j.micpath.2022.105694 PMid:35921951
17. Bachhar A, Barman S, Sarkar A, Bose A, Biswas P, Mandal S. Advances in biopolymer-based floating raft drug delivery systems for gastroretentive therapy. J Biomater Sci Polym Ed. Published online March 5, 2026:1-39. https://doi.org/10.1080/09205063.2026.2636795 PMid:41784228
18. Siripruekpong W, Wiwattanapatapee R, Chambin O, Assifaoui A. Structural and mechanistic exploration in the development of floating drug delivery systems using calcium-pectinate gels with sodium bicarbonate as CO2 gas-forming agent. J Drug Deliv Sci Technol. 2025;107:106729. https://doi.org/10.1016/j.jddst.2025.106729
19. Puyathorn N, Senarat S, Lertsuphotvanit N, Phaechamud T. Physicochemical and Bioactivity Characteristics of Doxycycline Hyclate-Loaded Solvent Removal-Induced Ibuprofen-Based In Situ Forming Gel. Gels. 2023;9(2):128. https://doi.org/10.3390/gels9020128 PMid:36826298 PMCid:PMC9956372
20. Lee CS, Hwang HS. Starch-Based Hydrogels as a Drug Delivery System in Biomedical Applications. Gels. 2023;9(12):951. https://doi.org/10.3390/gels9120951 PMid:38131937 PMCid:PMC10743264
21. Mishra MK, Shukla D, Sharma S, Sharma JN, Singh TP. From Liquid to Gel: Multifunctional Stimuli-responsive Polymers for Targeted Oral Drug Delivery. AAPS PharmSciTech. 2026;27(7):285. https://doi.org/10.1208/s12249-026-03519-y PMid:42717126
22. Kolawole OM, Cook MT. In situ gelling drug delivery systems for topical drug delivery. European Journal of Pharmaceutics and Biopharmaceutics. 2023;184:36-49. https://doi.org/10.1016/j.ejpb.2023.01.007 PMid:36642283
23. Basak A, Ghosh S, Pattanayak D, Das S. Floating-Mucoadhesive Gastro-Retentive Tablets for Enhanced Oral Delivery of Glimepiride: Formulation, Optimization, and Controlled Release. AAPS PharmSciTech. 2026;27(3):142. https://doi.org/10.1208/s12249-026-03395-6 PMid:41840294
24. A Gellan Gum/Sodium Alginate-based gastric-protective hydrogel loaded with a combined herbal extract consisting of Panax notoginseng, Bletilla striata and Dendrobium officinale.
25. Afrose N, Chakraborty R, Kuotsu K. A strategic design improvement in patient-centric sustained delivery of metoprolol succinate using natural gum blend matrix: design, development and in-vitro comparative evaluation. Journal of Polymer Research. 2023;30(9):367. https://doi.org/10.1007/s10965-023-03757-9
26. Bhowmik A, Dey C, Giri TK, Mukherjee K. Properties of Polymers Enabling In Situ Gel Formation. In: In Situ Gellable Hydrogels for Drug Delivery and Tissue Engineering. Springer Nature Singapore; 2026:33-61. https://doi.org/10.1007/978-981-95-6619-8_2
27. Rahbar N, Darvish S, Farrahi F, Kouchak M. Chitosan/carbomer nanoparticles- laden in situ gel for improved ocular delivery of timolol: in vitro, in vivo, and ex vivo study. Drug Deliv Transl Res. 2025;15(4):1210-1220. https://doi.org/10.1007/s13346-024-01663-1 PMid:38976207
28. Lv Q, Xiao T, Dong G, et al. Preparation and characterization of starch carbamate modified natural sodium alginate composite hydrogel blend formulation and its application for slow-release fertilizer. Int J Biol Macromol. 2024;278:134713. https://doi.org/10.1016/j.ijbiomac.2024.134713 PMid:39154686
29. Mori D, Dudhat K, Soniwala M, et al. Polymers used in pharmaceutical industry for oral delivery: insight to synthesis, structure-activity relationship, and recent applications. Polymer Bulletin. 2024;81(18):16373-16413. https://doi.org/10.1007/s00289-024-05509-1
30. Dong W, Ji J, Wang X, et al. The biomedical applications of flavonoid-containing hydrogels. Phytochemistry Reviews. Published online August 10, 2026. https://doi.org/10.1007/s11101-026-10294-y
31. Golshani S, Vatanara A, Balalaie S, Kadkhoda Z, Abdollahi M, Amin M. Development of a Novel Histatin-5 Mucoadhesive Gel for the Treatment of Oral Mucositis: In Vitro Characterization and In Vivo Evaluation. AAPS PharmSciTech. 2023;24(7):177. https://doi.org/10.1208/s12249-023-02632-6 PMid:37639072
32. Liu G, Mei D, Wu H, Zhang W. Core-shell floating hydrogel assembly for sustained dual-drug delivery and ultrasound imaging in rheumatoid arthritis. Appl Mater Today. 2026;52:103369. https://doi.org/10.1016/j.apmt.2026.103369
33. He S, Nielsen CU, Mu H, Jacobsen J. In vitro and ex vivo evaluation of bilayered effervescent microenvironmental pH modifying buccal films with saquinavir. J Drug Deliv Sci Technol. 2022;78:103954. https://doi.org/10.1016/j.jddst.2022.103954
34. Ferreira CMH, Pinto ISS, Soares E V., Soares HMVM. (Un)suitability of the use of pH buffers in biological, biochemical and environmental studies and their interaction with metal ions - a review. RSC Adv. 2015;5(39):30989-31003. https://doi.org/10.1039/C4RA15453C
35. de Saldanha Simon E, Wingert NR, Gobetti C, et al. Development, Quality by Design-Based Optimization, and Stability Assessment of Oral Liquid Formulations Containing Baclofen for Hospital Use. AAPS PharmSciTech. 2022;23(8):301. https://doi.org/10.1208/s12249-022-02447-x PMid:36385217
36. Okoye CO, Okeke ES, Ezeorba TPC, Chukwudozie KI, Chiejina CO, Fomena Temgoua NS. Microbial and Bio-based Preservatives: Recent Advances in Antimicrobial Compounds. In: 2022:53-74. https://doi.org/10.1007/978-981-19-5711-6_4
37. Okeke OC, Boateng JS. Composite HPMC and sodium alginate based buccal formulations for nicotine replacement therapy. Int J Biol Macromol. 2016;91:31-44. https://doi.org/10.1016/j.ijbiomac.2016.05.079 PMid:27222284
38. Song Z, Hou J, Liu X, Wei Q, Hao H, Zhang L. Conformance control for CO2-EOR in naturally fractured low permeability oil reservoirs. J Pet Sci Eng. 2018;166:225-234. https://doi.org/10.1016/j.petrol.2018.03.030
39. Khan I, Khan I, Saeed K, et al. Polymer nanocomposites: an overview. In: Smart Polymer Nanocomposites. Elsevier; 2023:167-184. https://doi.org/10.1016/B978-0-323-91611-0.00017-7
40. Tarhini A, Tehrani-Bagha AR. Advances in Preparation Methods and Conductivity Properties of Graphene-based Polymer Composites. Applied Composite Materials. 2023;30(6):1737-1762. https://doi.org/10.1007/s10443-023-10145-5
41. Rusdin A, Mohd Gazzali A, Ain Thomas N, et al. Advancing Drug Delivery Paradigms: Polyvinyl Pyrolidone (PVP)-Based Amorphous Solid Dispersion for Enhanced Physicochemical Properties and Therapeutic Efficacy. Polymers (Basel). 2024;16(2):286. https://doi.org/10.3390/polym16020286 PMid:38276694 PMCid:PMC10820039
42. Moaaz EM, Abdel-Moety EM, Rezk MR, Fayed AS. Smartphone based TLC approach versus conventional densitometric measurement for the simultaneous determination of donepezil and memantine, content uniformity testing along with greenness and whiteness assessment. Sustain Chem Pharm. 2024;42:101789. https://doi.org/10.1016/j.scp.2024.101789
43. Hao J, Yang M, Mintah BK, et al. Chemometric monitoring of critical parameters in rice wine fermentation using near-infrared spectroscopy with ultrasound-assisted S. cerevisiae cultivation. Microchemical Journal. 2026;223:117397. https://doi.org/10.1016/j.microc.2026.117397
44. Nasal administration of a temozolomide-loaded thermoresponsive nanoemulsion reduces tumor growth in a preclinical glioblastoma model.
45. Shen Y, Tan X, Zhou L, et al. An injectable in situ gel formed by ropivacaine with small lipid molecules to achieve long-term postoperative analgesia. Acta Biomater. 2025;198:151-160. https://doi.org/10.1016/j.actbio.2025.04.033 PMid:40246260
46. Kam LY, Wong JW, Yuen KH. HPMC Substitution Influences the Buoyancy and Release in Gastroretentive Floating Tablets. AAPS PharmSciTech. 2026;27(1):77. https://doi.org/10.1208/s12249-025-03306-1 PMid:41540294
47. Zhang J, Yan Y, Jia W, Yang W, Wang Q, Zhao S. Design and application of gel coagulation-spontaneous flotation integrated process in water treatment: “Clouds in water.” Water Res. 2023;243:120407. https://doi.org/10.1016/j.watres.2023.120407 PMid:37516081
48. Kwang GD, Sampathkumar K, Loo SCJ. Ultralong floating hydrogel raft for prolonged gastric retention. MRS Bull. 2023;48(4):342-350. https://doi.org/10.1557/s43577-022-00406-2
49. Chiani E, Beaucamp A, Hamzeh Y, Azadfallah M, Thanusha AV, Collins MN. Synthesis and characterization of gelatin/lignin hydrogels as quick release drug carriers for Ribavirin. Int J Biol Macromol. 2023;224:1196-1205. https://doi.org/10.1016/j.ijbiomac.2022.10.205 PMid:36309240
50. Akalin GO. Alginate/carboxymethylcellulose-based hydrogels as pH-sensitive drug delivery systems: facile production with enhanced degradation, thermal and mechanical properties. Iranian Polymer Journal. 2023;32(8):1013-1032. https://doi.org/10.1007/s13726-023-01182-9
51. Barman S, Sarkar A, Das U, Mandal S. Double Target Strategy of Novel Floating Raft System Containing Metronidazole. J Pharm Innov. 2025;20(6):230. https://doi.org/10.1007/s12247-025-10187-1
52. Khan BA, Ahmad N, Alqahtani A, Baloch R, Rehman AU, Khan MK. Formulation development of pharmaceutical nanoemulgel for transdermal delivery of feboxostat: Physical characterization and in vivo evaluation. European Journal of Pharmaceutical Sciences. 2024;195:106665. https://doi.org/10.1016/j.ejps.2023.106665 PMid:38056779
53. Gururaj N, Vinod V, Vijayakumar K. Deep grading of mangoes using Convolutional Neural Network and Computer Vision. Multimed Tools Appl. 2023;82(25):39525-39550. https://doi.org/10.1007/s11042-021-11616-2
54. Chaikham P, Yutsapremanon S, Baipong S, et al. High pressure processing of sweet corn milk yogurt: A plant-based probiotic carrier with enhanced stability. Food Chemistry Advances. 2025;9:101174. https://doi.org/10.1016/j.focha.2025.101174
55. Abd Ellah NH, Helmy AM, Tammam OY, El-Sherif MW, Abouelmagd SA. Dual-responsive in situ gelling polymer matrix for tunable ketamine general anesthesia in experimental animals. Int J Pharm. 2024;652:123820. https://doi.org/10.1016/j.ijpharm.2024.123820 PMid:38242258
56. Liu A, Cui S, Song L, et al. Ultrafast self-gelling, superabsorbent, and adhesive chitosan-based hemostatic powders for rapid hemostasis and wound healing. Carbohydr Polym. 2025;355:123362. https://doi.org/10.1016/j.carbpol.2025.123362 PMid:40037735
57. Bendaouia A, Ismaili T, Najib I, et al. Intelligent real-time flotation froth stability monitoring using embedded computer vision: lead (Pb) processing case study. The International Journal of Advanced Manufacturing Technology. 2025;141(3-4):1313-1328. https://doi.org/10.1007/s00170-025-16740-z
58. Rodrigues GS, Buranello LP, Barboza JM, et al. Pharmacomagnetography of floating gastroretentive systems in vivo in different prandial states evaluated by AC biosusceptometry. European Journal of Pharmaceutics and Biopharmaceutics. 2026;218:114907. https://doi.org/10.1016/j.ejpb.2025.114907 PMid:41207573
59. Salah El-Din SH, Mahmoud AM, Morsi A. Eco-friendly RP-HPLC method for simultaneous determination of water-soluble and fat-soluble vitamins in nano-formula and pharmaceutical dosage forms. BMC Chem. 2025;19(1):76. https://doi.org/10.1186/s13065-025-01441-1 PMid:40114284 PMCid:PMC11927356
60. Ali A, Hussain MA, Haseeb MT, et al. Synthesis, characterization, and acute toxicity of pH-responsive Salvia spinosa mucilage-co-acrylic acid hydrogel: A smart excipient for drug release applications. React Funct Polym. 2023;182:105466. https://doi.org/10.1016/j.reactfunctpolym.2022.105466
61. Qin Z, Yang Y, Zhang Z, et al. A Critical Review: Gel-Based Edible Inks for 3D Food Printing: Materials, Rheology-Geometry Mapping, and Control. Gels. 2025;11(10):780. https://doi.org/10.3390/gels11100780 PMid:41149385 PMCid:PMC12563521
62. Kubinski AM, Sosa RD, Shivkumar G, et al. Predictive dissolution modeling across USP apparatuses I, II, and III. J Pharm Sci. 2025;114(6):103765. https://doi.org/10.1016/j.xphs.2025.103765 PMid:40107419
63. Santadkha T, Skolpap W, Thitapakorn V. Diffusion Modeling and In Vitro Release Kinetics Studies of Curcumin−Loaded Superparamagnetic Nanomicelles in Cancer Drug Delivery System. J Pharm Sci. 2022;111(6):1690-1699. https://doi.org/10.1016/j.xphs.2021.11.015 PMid:34838781
64. Chen YC, Shishikura S, Moseson DE, et al. Control of drug release kinetics from hot-melt extruded drug-loaded polycaprolactone matrices. Journal of Controlled Release. 2023;359:373-383. https://doi.org/10.1016/j.jconrel.2023.05.049 PMid:37295729
65. Neolaka YAB, Lawa Y, Riwu M, et al. Synthesis of Zinc(II)-natural zeolite mordenite type as a drug carrier for ibuprofen: Drug release kinetic modeling and cytotoxicity study. Results Chem. 2022;4:100578. https://doi.org/10.1016/j.rechem.2022.100578
66. Wang M, Li N, Guo X, et al. Development of microemulsions-filled sodium alginate-chitosan composite hydrogels: Preparation, characterization and release kinetics analysis. Food Hydrocoll. 2025;163:111059. https://doi.org/10.1016/j.foodhyd.2025.111059
67. Kalyani P, Khandelwal M. Drug release kinetics from in-situ modulated agar/chitosan-bacterial cellulose patches for differently soluble drugs. Int J Biol Macromol. 2024;283:137602. https://doi.org/10.1016/j.ijbiomac.2024.137602 PMid:39549810
68. Development, Optimization and Evaluation of Naproxen Amorphous ASDs Tablets for Enhanced Solubility and Dissolution Using Hydrophilic Polymers.
69. Kumar G, Verma V. Formulation and simultaneous estimation of sustained release bilayer tablet containing polythiazide and reserpine. Curr Pharm Anal. 2026;22(2):169-180. https://doi.org/10.1016/j.cpan.2026.01.002
70. Potent Therapeutic Efficacy of 9-Bromo-Noscapine Against Breast Cancer Cells Via Enhanced Bioavailability of the Noscapine-Cyclodextrin Inclusion Complex.
71. Shariful Juhari MH, Luthfi AAI, Saleh NM, et al. Pineapple peel cellulose based eco-friendly fertilizer nanocomposites for improved nutrient delivery. Sci Rep. 2026;16(1):8971. https://doi.org/10.1038/s41598-025-32774-5 PMid:41708668 PMCid:PMC12987989
72. Mathew D, Thomas B, NM S, George J, EK R. Trimethyl Chitosan-Based Amphotericin B Nanoparticles: Improved Gastrointestinal Stability, Hemocompatibility, Monomeric Stabilization, and Controlled Drug Release. Bionanoscience. 2025;15(3):520. https://doi.org/10.1007/s12668-025-02117-9
73. Rehman Q, Akash MSH, Rasool MF, Rehman K. Role of Kinetic Models in Drug Stability. In: Drug Stability and Chemical Kinetics. Springer Singapore; 2020:155-165. https://doi.org/10.1007/978-981-15-6426-0_11 PMCid:PMC7174708
74. Patel M, Parikh D, Parihar A, et al. Protein and Peptide Therapeutics: Stability Challenges, Regulatory Demands, and Innovative Formulation Solutions for Enhanced Clinical Effectiveness. Protein Pept Lett. 2025;32. https://doi.org/10.2174/0109298665375151250626124048 PMid:40660448
75. EMERGING FRONTIERS IN THE DRUG FORMULATION DESIGN. INTECHOPEN; 2025.
76. Alexeeva O V., Konstantinova ML, Siracusa V, et al. Characterization and Evaluation of Zero-Order Release System Comprising Glycero-(9,10-trioxolane)-trialeate and PLA: Opportunity for Packaging and Biomedicine Applications. Polymers (Basel). 2024;16(24):3554. https://doi.org/10.3390/polym16243554 PMid:39771406 PMCid:PMC11679401
77. Khan MFH, Baudin F, Sudalaiyadum Perumal A, Kamen AA. Freeze-Drying of mRNA-LNPs Vaccines: A Review. Vaccines (Basel). 2025;13(8):853. https://doi.org/10.3390/vaccines13080853 PMid:40872937 PMCid:PMC12389932
78. Zhang B, Bai Y, Li X, Wang Y, Dong J, Jin Z. Effects of molecular entanglements in amylopectin on the anti-thixotropy, gel properties and viscosity properties. Food Hydrocoll. 2024;154:110115. https://doi.org/10.1016/j.foodhyd.2024.110115
79. Wang R, Chang Y, Hartel RW, Zhang Y, Wang S. Soluble dietary fibers as structuring agents in gelatin gelation: Effects on phase behavior, network formation, water mobility, and colorant stability in low- and high-solid matrices. Food Hydrocoll. 2026;174:112410. https://doi.org/10.1016/j.foodhyd.2025.112410
80. Pandey P, Sil D, Komal KM, Kumar M. Innovative approaches in HELICOBACTER pylori therapy: Clinical trials and advancements in Gastro-Retentive drug delivery systems. Arab Journal of Gastroenterology. 2025;26(4):473-484. https://doi.org/10.1016/j.ajg.2025.09.010 PMid:41206255
81. Takbirgou H, Salami M, Askari G, Emam-Djomeh Z, Kennedy JF. Characterization of novel alginate-Aloe Vera raft systems for treatment of gastroesophageal reflux disease. Int J Biol Macromol. 2024;257:128686. https://doi.org/10.1016/j.ijbiomac.2023.128686 PMid:38092117
82. Jacob S, Kather FS, Satyam SM, et al. Injectable In Situ Thermoreversible Gel Depot System of Lidocaine Nanoemulsion for Prolonged Anesthetic Activity in Dental and Operative Procedures. Pharmaceutics. 2025;17(10):1355. https://doi.org/10.3390/pharmaceutics17101355 PMid:41155990 PMCid:PMC12567530
83. Bhalala K, Jadeja D, Dudhat K. Microspheres: Preparation Methods, Advances, Applications, and Challenges in Drug Delivery. Biomedical Materials & Devices. 2026;4(1):221-260. https://doi.org/10.1007/s44174-025-00281-w
84. Synthesis and performance evaluation of multi-crosslinked preformed particle gels with ultra-high strength and high-temperature and high-salinity resistance for conformance control.
85. Formulation optimization of emulsifier-based hydrated gel cake improver for α-crystal stabilization using D-optimal mixture design.
86. Nayak C, Swain RP, Mohapatra R, Panigrahi KC. Next-Generation Nanostructured Lipid Carriers: A Review of Latest Trends and Innovations. Biomedical Materials & Devices. Published online December 4, 2025. https://doi.org/10.1007/s44174-025-00605-w
87. Real JP, Frenquelli E, Barrientos BA, Palma SD, Real DA. The use of hydrogels in oral drug delivery. In: Hydrogels in Drug Delivery. Elsevier; 2025:351-378. https://doi.org/10.1016/B978-0-443-22017-3.00007-X
88. Srinatha N, Battu S, Vishwanath BA. Microsponges: a promising frontier for prolonged release-current perspectives and patents. Beni Suef Univ J Basic Appl Sci. 2024;13(1):60. https://doi.org/10.1186/s43088-024-00519-4
89. Wirth T, Lafforgue P, Pham T. NSAID: Current limits to prescription. Joint Bone Spine. 2024;91(4):105685. https://doi.org/10.1016/j.jbspin.2023.105685 PMid:38159794
90. Sebaa R, AlMalki RH, Sukkarieh H, et al. Systemic Metabolic Alterations Induced by Etodolac in Healthy Individuals. Pharmaceuticals. 2025;18(8):1155. https://doi.org/10.3390/ph18081155 PMid:40872546 PMCid:PMC12388885
91. Drăgoi CM, Nicolae AC, Dumitrescu IB. The Indole Scaffold in Biochemistry and Therapeutics: A Privileged Structure with Diverse Chemical, Biological, and Clinical Significance. Targets. 2026;4(1):4. https://doi.org/10.3390/targets4010004
92. Zou Y, Zhang J, Chen L, Xu Q, Yao S, Chen H. Targeting Neuroinflammation in Central Nervous System Diseases by Oral Delivery of Lipid Nanoparticles. Pharmaceutics. 2025;17(3):388. https://doi.org/10.3390/pharmaceutics17030388 PMid:40143051 PMCid:PMC11944764
93. Allegaert K, Mitra S, Smits A, Turner MA. Advocating for drug development in newborn infants. Early Hum Dev. 2024;199:106136. https://doi.org/10.1016/j.earlhumdev.2024.106136 PMid:39488008
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Copyright (c) 2026 Rupesh Kumar Sahu , Niharika Sahu , Ruchi Gupta , Dharmendra Sahu , Rahul Dev , Shiv Kumar Bhardwaj
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