Nanocarrier Platforms in Cancer Therapeutics: Design, Advances and Clinical Translation Challenges
Abstract
Nanotechnology has emerged as a transformative frontier for detecting and treating various types of tumours more accurately. As a leading technology, nanotechnology assists in overcoming the issues linked with traditional antitumor drug systems. Nanocarriers (NCs) are colloidal systems developed for precise drug delivery; their main objective is to surpass the protective and efficient barriers.
Nanocarriers have been widely studied over the last few decades as they are highly helpful and play an important role in drug delivery across different fields. They show better performance compared to other methods by overcoming the limitations related to low targeting ability, damage to healthy cells, toxicity, and immediate drug release.
To achieve this goal, novel NCs like microemulsions, vesicular (liposomes), and nanoparticular NCs are created and explored. These new NCs have unique improved penetration and retention in the tumour tissue. Nano-therapy has advanced the delivery of chemotherapeutic medicines in cancer. Additionally, their uses in many other therapeutic areas have been remarkable, and there is yet much more to be discovered to facilitate their successful clinical translation.
Keywords: Nanotechnology, Nanocarriers, Targeted therapy, Cancer therapeutics
Keywords:
Nanocarriers, Cancer therapeutics, Trageted therapy, NanotechnologyDOI
https://doi.org/10.22270/jddt.v16i9.7852References
1. Edis Z, Wang J, Waqas MK, Ijaz M, Ijaz M. Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives. Int J Nanomedicine. 2021 Feb;Volume 16:1313-30. https://doi.org/10.2147/IJN.S289443 PMid:33628022
2. Arafeh R, Shibue T, Dempster JM, Hahn WC, Vazquez F. The present and future of the Cancer Dependency Map. Nat Rev Cancer. 2025 Jan 28;25(1):59-73. https://doi.org/10.1038/s41568-024-00763-x PMid:39468210
3. Imtiaz S, Ferdous UT, Nizela A, Hasan A, Shakoor A, Zia AW, et al. Mechanistic study of cancer drug delivery: Current techniques, limitations, and future prospects. Eur J Med Chem. 2025 Jun;290:117535. https://doi.org/10.1016/j.ejmech.2025.117535 PMid:40132495
4. Nurgali K, Jagoe RT, Abalo R. Editorial: Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae? Front Pharmacol. 2018 Mar 22;9. https://doi.org/10.3389/fphar.2018.00245 PMid:29623040 PMCid:PMC5874321
5. Zhang X, Li Y, Wei M, Liu C, Yu T, Yang J. Cetuximab-modified silica nanoparticle loaded with ICG for tumor-targeted combinational therapy of breast cancer. Drug Deliv. 2019 Jan 1;26(1):129-36. https://doi.org/10.1080/10717544.2018.1564403 PMid:30798640
6. How CW, Rasedee A, Manickam S, Rosli R. Tamoxifen-loaded nanostructured lipid carrier as a drug delivery system: Characterization, stability assessment and cytotoxicity. Colloids Surf B Biointerfaces. 2013 Dec;112:393-9. https://doi.org/10.1016/j.colsurfb.2013.08.009 PMid:24036474
7. Zhu J, Lee H, Huang R, Zhou J, Zhang J, Yang X, et al. Harnessing nanotechnology for cancer treatment. Front Bioeng Biotechnol. 2025 Jan 20;12. https://doi.org/10.3389/fbioe.2024.1514890 PMid:39902172 PMCid:PMC11788409
8. Virlley S, Shukla S, Arora S, Shukla D, Nagdiya D, Bajaj T, et al. Recent advances in microwave-assisted nanocarrier based drug delivery system: Trends and technologies. J Drug Deliv Sci Technol. 2023 Sep;87:104842. https://doi.org/10.1016/j.jddst.2023.104842
9. Khan Z, Khan N, Geetha M, Veettil RP, Kasote DM, Hasan A, et al. Therapeutic applications of nanobots and nanocarriers in cancer treatment. Analytical Sciences. 2025 Aug 4;41(8):1305-24. https://doi.org/10.1007/s44211-025-00799-5 PMid:40465130 PMCid:PMC12307532
10. Cheng X, Yan H, Pang S, Ya M, Qiu F, Qin P, et al. Liposomes as Multifunctional Nano-Carriers for Medicinal Natural Products. Front Chem. 2022 Aug 8;10. https://doi.org/10.3389/fchem.2022.963004 PMid:36003616 PMCid:PMC9393238
11. Shaik Nazma, Y Prasanth. Nanocarriers and their Types for Targeted Drug Delivery. Int J Pharm Sci Rev Res. 2022 Nov 15;21-8. https://doi.org/10.47583/ijpsrr.2022.v77i01.004
12. Pandey H, Rani R, Agarwal V. Liposome and Their Applications in Cancer Therapy. Brazilian Archives of Biology and Technology. 2016;59(0). https://doi.org/10.1590/1678-4324-2016150477
13. Bozzuto G, Molinari A. Liposomes as nanomedical devices. Int J Nanomedicine. 2015 Feb;975. https://doi.org/10.2147/IJN.S68861 PMid:25678787 PMCid:PMC4324542
14. Mu H, Holm R. Solid lipid nanocarriers in drug delivery: characterization and design. Expert Opin Drug Deliv. 2018 Aug 3;15(8):771-85. https://doi.org/10.1080/17425247.2018.1504018 PMid:30064267
15. Bukke SPN, Venkatesh C, Bandenahalli Rajanna S, Saraswathi TS, Kusuma PK, Goruntla N, et al. Solid lipid nanocarriers for drug delivery: design innovations and characterization strategies-a comprehensive review. Discover Applied Sciences. 2024 May 16;6(6):279. https://doi.org/10.1007/s42452-024-05897-z
16. German-Cortés J, Vilar-Hernández M, Rafael D, Abasolo I, Andrade F. Solid Lipid Nanoparticles: Multitasking Nano-Carriers for Cancer Treatment. Pharmaceutics. 2023 Mar 3;15(3):831. https://doi.org/10.3390/pharmaceutics15030831 PMid:36986692 PMCid:PMC10056426
17. Kesharwani P, Jain K, Jain NK. Dendrimer as nanocarrier for drug delivery. Prog Polym Sci. 2014 Feb;39(2):268-307. https://doi.org/10.1016/j.progpolymsci.2013.07.005
18. Parajapati S, Maurya S, Das M, Tilak VK, Verma KK, Dhakar RC. Potential Application of Dendrimers in Drug Delivery: A Concise Review and Update. Journal of Drug Delivery and Therapeutics. 2016;6(2):71-88 https://doi.org/10.22270/jddt.v6i2.1195
19. Prajapati SK, Maurya SD, Das MK, Tilak VK, Verma KK, Dhakar RC, Dendrimers in drug delivery, diagnosis and therapy: basics and potential applications, Journal of Drug Delivery and Therapeutics. 2016;6(1):67-92 https://doi.org/10.22270/jddt.v6i1.1190
20. Dendrimers and their Applications as Novel Drug Delivery Carriers. J Appl Pharm Sci. 2013. https://doi.org/10.7324/JAPS.2013.3924
21. Hari SK, Gauba A, Shrivastava N, Tripathi RM, Jain SK, Pandey AK. Polymeric micelles and cancer therapy: an ingenious multimodal tumor-targeted drug delivery system. Drug Deliv Transl Res. 2023 Jan 21;13(1):135-63. https://doi.org/10.1007/s13346-022-01197-4 PMid:35727533
22. Ghosh B, Biswas S. Polymeric micelles in cancer therapy: State of the art. Journal of Controlled Release. 2021 Apr;332:127-47. https://doi.org/10.1016/j.jconrel.2021.02.016 PMid:33609621
23. Kakad S, Kshirsagar S, Sonar A, Pawar M, Pingale P. Chapter 1 Nanocarrier drug delivery System: recent advancement and future potential. In: Nanocarrier Drug Delivery Systems. De Gruyter; 2024. p. 1-30. https://doi.org/10.1515/9783111320847-001
24. Cho S, Rasoulianboroujeni M, Kang RH, Kwon GS. From Conventional to Next-Generation Strategies: Recent Advances in Polymeric Micelle Preparation for Drug Delivery. Pharmaceutics. 2025 Oct 21;17(10):1360. https://doi.org/10.3390/pharmaceutics17101360 PMid:41155995 PMCid:PMC12566873
25. Gressler S, Hipfinger C, Part F, Pavlicek A, Zafiu C, Giese B. A systematic review of nanocarriers used in medicine and beyond - definition and categorization framework. J Nanobiotechnology. 2025 Feb 7;23(1):90. https://doi.org/10.1186/s12951-025-03113-7 PMid:39920688 PMCid:PMC11804063
26. Theivendran S, Lazarev S, Yu C. Mesoporous silica/organosilica nanoparticles for cancer immunotherapy. Exploration. 2023 Jun 9;3(3). https://doi.org/10.1002/EXP.20220086 PMid:37933387 PMCid:PMC10624378
27. Zhang C, Xie H, Zhang Z, Wen B, Cao H, Bai Y, et al. Applications and Biocompatibility of Mesoporous Silica Nanocarriers in the Field of Medicine. Front Pharmacol. 2022 Jan 28;13. https://doi.org/10.3389/fphar.2022.829796 PMid:35153797 PMCid:PMC8832880
28. Agarwal K, Rai H, Mondal S. Quantum dots: an overview of synthesis, properties, and applications. Mater Res Express. 2023 Jun 1;10(6):062001. https://doi.org/10.1088/2053-1591/acda17
29. Hamidu A, Pitt WG, Husseini GA. Recent Breakthroughs in Using Quantum Dots for Cancer Imaging and Drug Delivery Purposes. Nanomaterials. 2023 Sep 15;13(18):2566. https://doi.org/10.3390/nano13182566 PMid:37764594 PMCid:PMC10535728
30. Naik K, Chaudhary S, Ye L, Parmar AS. A Strategic Review on Carbon Quantum Dots for Cancer-Diagnostics and Treatment. Front Bioeng Biotechnol. 2022 May 18;10. https://doi.org/10.3389/fbioe.2022.882100 PMid:35662840 PMCid:PMC9158127
31. Tietze R, Zaloga J, Unterweger H, Lyer S, Friedrich RP, Janko C, et al. Magnetic nanoparticle-based drug delivery for cancer therapy. Biochem Biophys Res Commun. 2015 Dec;468(3):463-70. https://doi.org/10.1016/j.bbrc.2015.08.022 PMid:26271592
32. Salahpour Anarjan F. Active targeting drug delivery nanocarriers: Ligands. Nano-Structures & Nano-Objects. 2019 Jul;19:100370. https://doi.org/10.1016/j.nanoso.2019.100370
33. Jiang M, Zhang K, Wang Z, Gao M, Su S, He J, et al. Nanomaterials in gene therapy and genome editing: challenges and emerging directions. J Nanobiotechnology. 2025 Dec 16;24(1):56. https://doi.org/10.1186/s12951-025-03895-w PMid:41402770 PMCid:PMC12822215
34. Batool S, Sohail S, ud Din F, Alamri AH, Alqahtani AS, Alshahrani MA, et al. A detailed insight of the tumor targeting using nanocarrier drug delivery system. Drug Deliv. 2023 Dec 31;30(1). https://doi.org/10.1080/10717544.2023.2183815 PMid:36866455 PMCid:PMC10191068
35. Alshawwa SZ, Kassem AA, Farid RM, Mostafa SK, Labib GS. Nanocarrier Drug Delivery Systems: Characterization, Limitations, Future Perspectives and Implementation of Artificial Intelligence. Pharmaceutics. 2022 Apr 18;14(4):883. https://doi.org/10.3390/pharmaceutics14040883 PMid:35456717 PMCid:PMC9026217
36. Das RP, Gandhi V V., Singh BG, Kunwar A. Passive and Active Drug Targeting: Role of Nanocarriers in Rational Design of Anticancer Formulations. Curr Pharm Des. 2019 Oct 21;25(28):3034-56. https://doi.org/10.2174/1381612825666190830155319 PMid:31470779
37. Torchilin VP. Passive and Active Drug Targeting: Drug Delivery to Tumors as an Example. In. 2010. p. 3-53. https://doi.org/10.1007/978-3-642-00477-3_1 PMid:20217525
38. Majumder J, Minko T. Multifunctional and stimuli-responsive nanocarriers for targeted therapeutic delivery. Expert Opin Drug Deliv. 2021 Feb 1;18(2):205-27. https://doi.org/10.1080/17425247.2021.1828339 PMid:32969740 PMCid:PMC7904578
39. Zhao X, Bai J, Yang W. Stimuli-responsive nanocarriers for therapeutic applications in cancer. Cancer Biol Med. 2021;18(2):319-35. https://doi.org/10.20892/j.issn.2095-3941.2020.0496 PMid:33764711 PMCid:PMC8185873
40. Pathak K, Ahmad MZ, Sahariah JJ, Sahariah M, Konwar S, Talukdar B, et al. Bioinspired nanocarriers for advanced drug delivery. Nano Express. 2025 Sep 30;6(3):032001. https://doi.org/10.1088/2632-959X/adff9f
41. Sabu C, Rejo C, Kotta S, Pramod K. Bioinspired and biomimetic systems for advanced drug and gene delivery. Journal of Controlled Release. 2018 Oct;287:142-55. https://doi.org/10.1016/j.jconrel.2018.08.033 PMid:30165138
42. Srujana S, Anjamma M, Alimuddin, Singh B, Dhakar RC, Natarajan S, Hechhu R. A Comprehensive Study on the Synthesis and Characterization of TiO2 Nanoparticles Using Aloe vera Plant Extract and Their Photocatalytic Activity against MB Dye. Adsorption Science & Technology. 2022;2022 https://doi.org/10.1155/2022/7244006
43. Ashrafizadeh M, Zarrabi A, Bigham A, Taheriazam A, Saghari Y, Mirzaei S, et al. (Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapy. Med Res Rev. 2023 Nov 11;43(6):2115-76. https://doi.org/10.1002/med.21971 PMid:37165896
44. Bhaskar S, Tian F, Stoeger T, Kreyling W, de la Fuente JM, Grazú V, et al. Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging. Part Fibre Toxicol. 2010 Dec 3;7(1):3. https://doi.org/10.1186/1743-8977-7-3 PMid:20199661 PMCid:PMC2847536
45. Xu Z, Xie Y, Chen W, Deng W. Nanocarrier‐Based Systems for Targeted Delivery: Current Challenges and Future Directions. MedComm (Beijing). 2025 Sep 21;6(9). https://doi.org/10.1002/mco2.70337 PMid:40859956 PMCid:PMC12371215
46. Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2021 Feb 4;20(2):101-24. https://doi.org/10.1038/s41573-020-0090-8 PMid:33277608
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