To develop and evaluate a Carbopol-based hydrogel containing Moringa oleifera root extract for antioxidant and antimicrobial diabetic wound management
Abstract
Background: Diabetic wounds are characterized by oxidative stress and infection, leading to delayed healing.
Objective: To develop a Carbopol-based hydrogel incorporating Moringa oleifera root extract.
Methods: Hydrogel formulations (F1–F6) were prepared and evaluated for physicochemical properties, drug release, antioxidant and antimicrobial activity.
Results: Batch F4 showed optimal pH (6.2), viscosity (15800 cP), and 98% drug release within 6 hours. Release followed Korsmeyer–Peppas kinetics (R² = 0.9864), indicating non-Fickian diffusion. The formulation exhibited significant antioxidant (~70%) and antimicrobial activity (24 mm zone).
Conclusion: The developed hydrogel demonstrates strong potential for diabetic wound management.
Keywords: Carbopol hydrogel, Moringa oleifera, diabetic wound, antioxidant, antimicrobial, drug release
Keywords:
Carbopol hydrogel, Moringa oleifera, diabetic wound, antioxidant, antimicrobial, drug releaseDOI
https://doi.org/10.22270/jddt.v16i6.7767References
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Copyright (c) 2026 Pratik Sanjeev Gunale, Aditya Uttam Waghmare, Kiran C. Rodage, Sameer Shafi, V.M. Dharashive, Kavita Shivkumar Sirgire
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