Antioxidant, anti-inflammatory and reproductive effects of the anti-diabetic polyherbal formulation, “Insulinevégétale”: Evidence from a case series from Cameroon
Abstract
Diabetes mellitus associated with oxidative stress, systemic inflammation, and male reproductive function impairment requires a holistic approach. This study investigated the effects of a polyherbal formulation, “Insulinevégétale” on biomarkers of oxidative stress, inflammation, and reproductive hormones in diabetes mellitus patients. This prospective case series conducted at the ‘Union des Tradi-praticiens en Plantes Médicinales du Cameroon’ headquarters in Foumbot (Cameroon) involved participants monitored at three time points. Serum biomarkers of inflammation, including high-sensitivity C-reactive protein (hsCRP), C-reactive protein (CRP), and interleukin-6 (IL-6), were measured. Oxidative stress status was evaluated using reduced glutathione (GSH) and superoxide dismutase (SOD) activity. Reproductive function was assessed through serum testosterone and luteinizing hormone (LH) levels. Inflammatory biomarkers reduced during treatment with hsCRP, CRP and IL-6 declining (p < 0.001) from 5.62 mg/L, 20.26 mg/L and 153.27 pg/mL at baseline to 2.97 mg/L, 7.32 mg/L and 20.91 pg/mL at endpoint, respectively. Conversely, antioxidant biomarkers were significantly improved, with the levels of GSH and SOD activity increasing (p < 0.001) from 2.57 µmol/L to 5.36 µmol/L and 83.16 U/mL to 112.32 U/mL, respectively. Likewise, reproductive hormonal parameters also showed improvement, as testosterone and LH levels increased (p < 0.001) from 1.73 nmol/L and 24.64 IU/L to 3.73 and 33.26 IU/L nmol/L, respectively. In summary, “Insulinevégétale” therapy attenuates inflammation and oxidative stress while restoring hormonal balance in individuals with diabetes, thereby helping to preserve male reproductive function. These findings suggest that this polyherbal formulation exerts beneficial effects against metabolic and endocrine disturbances, likely through its antioxidant and anti-inflammatory properties.
Keywords: Diabetes mellitus; Inflammation; Insulinevégétale; Oxidative stress; Polyherbal formulation; Reproductive hormones.
Keywords:
Diabetes mellitus, Inflammation, Insulinevégétale, Oxidative stress, Polyherbal formulation, Reproductive hormonesDOI
https://doi.org/10.22270/jddt.v16i5.7707References
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Copyright (c) 2026 Mariama Mbouh , Junior Tegha Kum Muankang , Antoine Kada Sanda, Brainda Anais Mbou Foudji , Jude Funwie Nforben , Raphael Ndam Teboh , Bertilla Kisevi , Gisele Longnjinou Zoum , Edouard Nantia Akono
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