SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF SOME HYDRAZONE DERIVATIVES
Abstract
A mixture of phenyl acetic acid (10gm, 0.003mole) in acetone, dimethyl Sulphate (10.45ml, 0.007mole), anhydrous potassium carbonate (2.8gm, 0.02mol) was refluxed on a water bath for 2 hr with occasional stirring give methyl 2-phenylacetate(1), Methyl 2-phenylacetate (1.78gm, 0.01mole) in alcohol was refluxed with hydrazine hydrate (0.38gm, 0.01mole) for 8hrs formed 2-phenylacetohydrazide, A mixture of substituted benzaldehyde (1.22gm, 0.01mole) and 2-phenyl acetohydrazide (1.5gm, 0.01mole) were dissolved in methanol then two drops of conc. HCl were added as catalyst and stirred at room temperature for 2hr formed N'-(2-chlorobenzylidene)-2-phenylacetohydrazide,N'-(3,4,5-trimethoxybenzylidene)-2-phenylacetohydrazide, N'-(furan-2-ylmethylene) -2-phenylacetohydrazide, and N'-(3,4,5-trimethoxybenzylidene) -2-phenylacetohydrazide
Key-Words: Phenyl acetic acid, Hydrazine-hydrate, NSAID’S, Anti-inflammatory.
DOI
https://doi.org/10.22270/jddt.v4i1.766Published
Abstract Display: 602 
PDF Downloads: 1199 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.