INSULIN RESISTANCE IN END STAGE RENAL DISEASE (ESRD) PATIENTS IN EASTERN INDIA: A POPULATION BASED OBSERVATIONAL STUDY
Background & Objective: Despite considerable advances made in the field of medicine in general, and nephrology in particular, Chronic Kidney Disease (CKD) and End Stage Renal Disease (ESRD) remain public health challenges of enormous proportion. Aim: Considering that the association between Insulin resistance and CKD and ESRD has been established in studies conducted abroad, we propose to verify the association in Indian setting i.e. among ESRD patients in eastern India. Materials and Methods: 95 patients were included in control group and 97 patients were included in ESRD group. Only consenting individuals chosen through the filters of appropriate inclusion and exclusion criteria were made part of the study. Results: The statistical software Minitab 16 was used to analyze the data. Serum fasting Insulin level, HOMA-IR, serum hsCRP, serum urea, serum creatinine levels were significantly higher in ESRD patients compared to age and sex matched control individuals.
Conclusion: Our study confirms the association between ESRD and IR found in other studies. Although the association between ESRD and IR has been established, the causality relation between them is not very clear. Further exploration of the issue is warranted.
End Stage Renal Disease, Chronic Kidney Disease, Insulin Resistance
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