Formulation and Evaluation of Monk Fruit Extract-Based Zero-Calorie Electrolyte Replenisher Powder: A Novel Functional Formulation

Authors

  • Unnati Suresh Patil Department of PharmaceuticsDepartment of Pharmaceutics, MET’s Institute of D Pharmacy, Nashik 422003, Maharashtra, India., MET's Institute Of D. Pharmacy, Nashik 422003, India
  • Monali Gangurde Department of Pharmaceutics, MET’s Institute of D Pharmacy, Nashik 422003, Maharashtra, India.
  • Darshan Shejwal Department of Pharmaceutics, MET’s Institute of D Pharmacy, Nashik 422003, Maharashtra, India.
  • Ravina Khandekar Department of Pharmaceutics, MET’s Institute of D Pharmacy, Nashik 422003, Maharashtra, India.
  • Snehal Ukhade Department of Pharmaceutics, MET’s Institute of D Pharmacy, Nashik 422003, Maharashtra, India.

Abstract

The present study aims to develop and evaluate a natural, zero-calorie electrolyte replenisher formulated using monk fruit extract (Siraitia grosvenorii) as a non-glycemic sweetener. Considering the increasing prevalence of diabetes, obesity, and excessive sugar consumption, this formulation provides a healthier alternative to conventional sugar-based oral rehydration products. A WHO ORS–derived electrolyte composition containing sodium chloride, potassium chloride, trisodium citrate, citric acid, and monk fruit extract was prepared by dry blending and packed in moisture-proof sachets. Physicochemical evaluation demonstrated favorable organoleptic properties, rapid solubility (28 ± 2 s), slightly acidic pH (6.5 ± 0.1), and low moisture content (2.1%), indicating good initial quality. Accelerated stability testing at 40°C/75% RH for 28 days showed a gradual increase in moisture content (up to 3.5%) and mild caking, while pH remained stable (6.4–6.5), confirming the absence of chemical degradation. The results suggest that the formulation is primarily affected by hygroscopicity and requires strong moisture-proof packaging for extended shelf life. Overall, the study demonstrates that monk fruit–sweetened electrolyte powder is a viable, stable, and clean-label alternative suitable for diabetics, ketogenic users, athletes, and general consumers seeking natural, zero-calorie hydration solutions. Further sensory and clinical studies are recommended to optimize taste and validate rehydration efficacy.

Keywords: Monk fruit; Mogrosides; Zero-calorie natural sweetener; Electrolyte replenisher; Hydration therapy; Diabetes-friendly formulation

Keywords:

Zero calories electrolyte replenisher , Diabetic friendly,keto friendly, athletes friendly , Monk fruit extract , Hydration therapy , Electrolyte Replenisher , Zero calorie natural sweetener

DOI

https://doi.org/10.22270/jddt.v16i2.7549

Author Biographies

Unnati Suresh Patil, Department of PharmaceuticsDepartment of Pharmaceutics, MET’s Institute of D Pharmacy, Nashik 422003, Maharashtra, India., MET's Institute Of D. Pharmacy, Nashik 422003, India

Department of Pharmaceutics, MET’s Institute of D Pharmacy, Nashik 422003, Maharashtra, India.

Monali Gangurde, Department of Pharmaceutics, MET’s Institute of D Pharmacy, Nashik 422003, Maharashtra, India.

Department of Pharmaceutics, MET’s Institute of D Pharmacy, Nashik 422003, Maharashtra, India.

Darshan Shejwal, Department of Pharmaceutics, MET’s Institute of D Pharmacy, Nashik 422003, Maharashtra, India.

Department of Pharmaceutics, MET’s Institute of D Pharmacy, Nashik 422003, Maharashtra, India.

Ravina Khandekar, Department of Pharmaceutics, MET’s Institute of D Pharmacy, Nashik 422003, Maharashtra, India.

Department of Pharmaceutics, MET’s Institute of D Pharmacy, Nashik 422003, Maharashtra, India.

Snehal Ukhade , Department of Pharmaceutics, MET’s Institute of D Pharmacy, Nashik 422003, Maharashtra, India.

Department of Pharmaceutics, MET’s Institute of D Pharmacy, Nashik 422003, Maharashtra, India.

References

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Published

2026-02-15
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How to Cite

1.
Patil US, Gangurde M, Shejwal D, Khandekar R, Ukhade S. Formulation and Evaluation of Monk Fruit Extract-Based Zero-Calorie Electrolyte Replenisher Powder: A Novel Functional Formulation. J. Drug Delivery Ther. [Internet]. 2026 Feb. 15 [cited 2026 May 26];16(2):156-63. Available from: https://jddtonline.info/index.php/jddt/article/view/7549

How to Cite

1.
Patil US, Gangurde M, Shejwal D, Khandekar R, Ukhade S. Formulation and Evaluation of Monk Fruit Extract-Based Zero-Calorie Electrolyte Replenisher Powder: A Novel Functional Formulation. J. Drug Delivery Ther. [Internet]. 2026 Feb. 15 [cited 2026 May 26];16(2):156-63. Available from: https://jddtonline.info/index.php/jddt/article/view/7549