Formulation and Evaluation of Monk Fruit Extract-Based Zero-Calorie Electrolyte Replenisher Powder: A Novel Functional Formulation
Abstract
The present study aims to develop and evaluate a natural, zero-calorie electrolyte replenisher formulated using monk fruit extract (Siraitia grosvenorii) as a non-glycemic sweetener. Considering the increasing prevalence of diabetes, obesity, and excessive sugar consumption, this formulation provides a healthier alternative to conventional sugar-based oral rehydration products. A WHO ORS–derived electrolyte composition containing sodium chloride, potassium chloride, trisodium citrate, citric acid, and monk fruit extract was prepared by dry blending and packed in moisture-proof sachets. Physicochemical evaluation demonstrated favorable organoleptic properties, rapid solubility (28 ± 2 s), slightly acidic pH (6.5 ± 0.1), and low moisture content (2.1%), indicating good initial quality. Accelerated stability testing at 40°C/75% RH for 28 days showed a gradual increase in moisture content (up to 3.5%) and mild caking, while pH remained stable (6.4–6.5), confirming the absence of chemical degradation. The results suggest that the formulation is primarily affected by hygroscopicity and requires strong moisture-proof packaging for extended shelf life. Overall, the study demonstrates that monk fruit–sweetened electrolyte powder is a viable, stable, and clean-label alternative suitable for diabetics, ketogenic users, athletes, and general consumers seeking natural, zero-calorie hydration solutions. Further sensory and clinical studies are recommended to optimize taste and validate rehydration efficacy.
Keywords: Monk fruit; Mogrosides; Zero-calorie natural sweetener; Electrolyte replenisher; Hydration therapy; Diabetes-friendly formulation
Keywords:
Zero calories electrolyte replenisher , Diabetic friendly,keto friendly, athletes friendly , Monk fruit extract , Hydration therapy , Electrolyte Replenisher , Zero calorie natural sweetenerDOI
https://doi.org/10.22270/jddt.v16i2.7549References
1. Gong X, Chen N, Ren K, Jia J, Wei K, Zhang L, et al. The Fruits of Siraitia grosvenorii: A Review of a Chinese Food-Medicine. Front Pharmacol [Internet]. 2019;10:1400. https://doi.org/10.3389/fphar.2019.01400 PMid:31849659 PMCid:PMC6903776
2. Pandey AK, Chauhan OP. Monk fruit (Siraitia grosvenorii) -health aspects and food applications [Internet]. Res.in. [cited 2025 Dec 8]. Available from: https://www.gbpuat.res.in/uploads/archive/17.3.1.pdf
3. Gulati S, Misra A. Sugar intake, obesity, and diabetes in India. Nutrients [Internet]. 2014;6(12):5955-74. https://doi.org/10.3390/nu6125955 PMid:25533007 PMCid:PMC4277009
4. Lang A, Kuss O, Filla T, Schlesinger S. Association between per capita sugar consumption and diabetes prevalence mediated by the body mass index: results of a global mediation analysis. Eur J Nutr [Internet]. 2021;60(4):2121-9. https://doi.org/10.1007/s00394-020-02401-2 PMid:33037438 PMCid:PMC8137616
5. Phytochemical analysis and medicinal properties of some selected traditional medicinal plants. International Journal of Agriculture and Biosciences. 2024; https://doi.org/10.47278/journal.ijab/2024.177
6. Liu H, Qi X, Yu K, Lu A, Lin K, Zhu J, et al. AMPK activation is involved in hypoglycemic and hypolipidemic activities of mogroside-rich extract from Siraitia grosvenorii (Swingle) fruits on high-fat diet/streptozotocin-induced diabetic mice. Food Funct [Internet]. 2019;10(1):151-62. https://doi.org/10.1039/C8FO01486H PMid:30516208
7. 周海银, 隆彩霞, 罗兰, 陈艳瑛, 刘萍萍, 肖政辉. 罗汉果皂苷Ⅵ对小鼠脓毒症致急性肝损伤的作用及其机制探讨. Zhongguo Dang Dai Er Ke Za Zhi [Internet]. 2020 [cited 2025 Dec 8];22(11):1233-9. Available from: http://www.zgddek.com/CN/10.7499/j.issn.1008-8830.2007088
8. Peteliuk V, Rybchuk L, Bayliak M, Storey KB, Lushchak O. Natural sweetener Stevia rebaudiana: functionalities, health benefits and potential risks [Internet]. IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund; 2021. http://dx.doi.org/10.17179/EXCLI2021-4211
9. Patel D. Monk fruit: Is this natural sweetener safe for diabetics? [Internet]. Continentalhospitals.com. [cited 2025 Dec 8]. Available from: https://continentalhospitals.com/blog/monk-fruit-is-this-natural-sweetener-safe-for-diabetics/
10. Dragomir N, Grigore D-M, Pogurschi EN. Beyond sugar: A holistic review of sweeteners and their role in modern nutrition. Foods [Internet]. 2025;14(18):3182. https://doi.org/10.3390/foods14183182 PMid:41008155 PMCid:PMC12470175
11. Johnson J. Monk fruit vs. stevia: Which is the best natural sweetener? [Internet]. Medicalnewstoday.com. Medical News Today; 2018 [cited 2025 Dec 8]. Available from: https://www.medicalnewstoday.com/articles/322769
12. Wazir M, Verma H, Singh J, Singh P, Passey S. The battle of natural sweeteners: A comprehensive guide to Monk fruit and Stevia. Curr Res Nutr Food Sci J [Internet]. 2025;13(1):24-45. https://doi.org/10.12944/CRNFSJ.13.1.2
13. Harshita K. Monk fruit (Siraitia grosvenorii): A comprehensive review of its sweetness, health benefits, and applications as a natural sweetener. Pharma Innov [Internet]. 2023 [cited 2025 Dec 8];12(6):3007-12. Available from: https://www.thepharmajournal.com/archives/?year=2023&vol=12&issue=6&ArticleId=20829
14. Who.int. [cited 2025 Dec 8]. Available from: https://iris.who.int/server/api/core/bitstreams/e52f1746-cf33-4a63-9f97-4c0bfaaeb230/content
Published
Abstract Display: 448
PDF Downloads: 220
PDF Downloads: 24 How to Cite
Issue
Section
Copyright (c) 2026 Unnati Suresh Patil, Monali Gangurde, Darshan Shejwal, Ravina Khandekar, Snehal Ukhade

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

.