MODIFIED NATURAL CARRIER IN SOLID DISPERSION FOR ENHANCEMENT OF SOLUBILITY OF POORLY WATER SOLUBLE DRUGS
Abstract
The solid dispersion is one of the most important and desirable technique of solubility enhancement, the use of natural carrier in solid dispersion gives prominent and ecofriendly results. Many carriers have limitations in enhancing solubility of poorly water soluble drugs due to their high viscosity and their hygroscopic nature, modifying natural gum at different temperature provides carrier which have low viscosity and high swelling capacity offers better alternative for natural carriers. Modification of natural gums also changes physical characteristics like swelling index, viscosity, water retention capacity and crystalline nature of powder into amorphous. It concludes that modified form of carrier always shows better desire properties for enhancing water solubility.
KEYWORDS: Solid dispersion, Modified natural gums, Carriers, Solubility.
DOI
https://doi.org/10.22270/jddt.v4i1.749Published
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