Intranasal nanoparticulate drug delivery systems for neurodegenerative disorders: an Overview

Authors

Abstract

Intranasal nanoparticulate drug delivery systems have received increased attention in pharmaceutical research due to their ability to increase drug bioavailability, bypass the blood-brain barrier (BBB), and provide non-invasive, patient-friendly alternatives to drug administration, particularly for drugs intended for central nervous system (CNS) disorders. Drugs delivered via nasal route can enter the CNS via the olfactory pathway or the trigeminal nerve pathway, enabling access to deeper regions. Intranasal nanoparticulate systems have several pharmacological benefits, including increased bioavailability, a faster onset of action, higher patient compliance, and less systemic adverse effects. Intranasal nanoparticulate drug delivery has shown promise in a variety of therapeutic areas, including Alzheimer's disease, Parkinson's disease, depression, and anxiety. Intranasal vaccinations and antibacterial Nanoparticle are also utilized to treat respiratory and viral illnesses. This technique is thought to be useful in brain-targeted chemotherapeutic drugs for glioblastoma treatment. The authors of this review attempted to investigate the pharmacological features of nanoparticulate drug delivery systems, including their benefits, mechanisms, formulation methodologies, and clinical applications.

Keywords: Alzheimer's disease, Drug delivery, Nanoparticle, Nasal route, Neuro inflammation, Parkinson’s disease, 

Keywords:

Alzheimer's disease, Drug delivery, Nanoparticle, Nasal route, inflammation, Parkinson’s disease

DOI

https://doi.org/10.22270/jddt.v15i11.7462

Author Biographies

Poonam Sahu , Columbia Institute of Pharmacy, Vill-Tekari, Near Vidhansabha, Raipur-493111, C.G., India

Columbia Institute of Pharmacy, Vill-Tekari, Near Vidhansabha, Raipur-493111, C.G., India

Kunal Chandrakar , University College of Pharmacy, CSVTU, Bhilai-491107, C.G., India

University College of Pharmacy, CSVTU, Bhilai-491107, C.G., India

Princy Kashyap , Department of Pharmacy, Guru Ghasidas Central University, Koni, Bilaspur-495009, C.G., India

Department of Pharmacy, Guru Ghasidas Central University, Koni, Bilaspur-495009, C.G., India

Manoj Kumar , Department of Pharmacy, Guru Ghasidas Central University, Koni, Bilaspur-495009, C.G., India

Department of Pharmacy, Guru Ghasidas Central University, Koni, Bilaspur-495009, C.G., India

Arvind Kumar , Faculty of Pharmacy, Kalinga University, Kotni, Naya Raipur-492001, C.G., India

Faculty of Pharmacy, Kalinga University, Kotni, Naya Raipur-492001, C.G., India

Abhisek Satapathy , Pt J.N.M. Medical College, Railway Station Rd, Moudhapara, Raipur-492001, C.G., India

Pt J.N.M. Medical College, Railway Station Rd, Moudhapara, Raipur-492001, C.G., India

Abinash Satapathy , College of Veterinary Science and Animal Husbandry, Anjora, Durg, 491001, C.G, India

College of Veterinary Science and Animal Husbandry, Anjora, Durg, 491001, C.G, India

Shiv Kumar Bhardwaj , Columbia Institute of Pharmacy, Vill-Tekari, Near Vidhansabha, Raipur-493111, C.G., India

Columbia Institute of Pharmacy, Vill-Tekari, Near Vidhansabha, Raipur-493111, C.G., India

Trilochan Satapathy , Columbia Institute of Pharmacy, Vill-Tekari, Near Vidhansabha, Raipur-493111, C.G., India

Columbia Institute of Pharmacy, Vill-Tekari, Near Vidhansabha, Raipur-493111, C.G., India

Manisha Chandrakar, University College of Pharmacy, CSVTU, Bhilai-491107, C.G., India

University College of Pharmacy, CSVTU, Bhilai-491107, C.G., India

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2025-11-15
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Sahu P, Chandrakar K, Kashyap P, Kumar M, Kumar A, Satapathy A, et al. Intranasal nanoparticulate drug delivery systems for neurodegenerative disorders: an Overview. J. Drug Delivery Ther. [Internet]. 2025 Nov. 15 [cited 2026 Jan. 19];15(11):134-55. Available from: https://jddtonline.info/index.php/jddt/article/view/7462

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Vol. 15 No. 11 (2025): Volume 15, Issue 11, November 2025

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Copyright (c) 2025 Poonam Sahu , Kunal Chandrakar , Princy Kashyap , Manoj Kumar , Arvind Kumar , Abhisek Satapathy , Abinash Satapathy , Shiv Kumar Bhardwaj , Trilochan Satapathy , Manisha Chandrakar

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Sahu P, Chandrakar K, Kashyap P, Kumar M, Kumar A, Satapathy A, et al. Intranasal nanoparticulate drug delivery systems for neurodegenerative disorders: an Overview. J. Drug Delivery Ther. [Internet]. 2025 Nov. 15 [cited 2026 Jan. 19];15(11):134-55. Available from: https://jddtonline.info/index.php/jddt/article/view/7462
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