Precise Evaluation of the Essential Metal Ions in Oral Rehydration Solution by Flame Emission Spectroscopy
Abstract
Three rapid, precise, and reliable analytical methods have been established for determining the concentrations of sodium and potassium in two distinct ORS formulations. The first method, use only one standard means measuring how bright the flame is for a sample solution and comparing it with the brightness of a standard solution, means known solution. The second method uses two standard solutions. It involves standardizing a reference substance using two-point bracketing, and the final result is calculated using mathematical formulas. The third method is a linear curve, which means finding how much of a substance is in a sample by comparing it to other sample with known amount. The concentration of a substance in an unknown sample is determined by measuring its flame intensity and comparing it with that of standards, since flame intensity is directly proportional to concentration. The linear range for sodium and potassium is in the range of 0-100 μg/ml. The developed methods were effectively utilized for the precise evaluation of sodium and potassium in commercially available ORS formulations. Accurate percentage yield indicate that all three methods are rapid, precise and reliable for the estimation of sodium and potassium in two different formulations of ORS.
Keywords: Metal ions, Oral Rehydration Solution, Flame emission spectroscopy
Keywords:
Metal ions, Oral Rehydration Solution, Flame emission spectroscopyDOI
https://doi.org/10.22270/jddt.v15i12.7455References
1. Chatwal G and Sham A "Instrumentals methods of Chemical Analysis" Himalaya Publishing House Mumbai. Reprint 2007; 2.367- 2.388.
2. Banerjee P, Bably P. "Determination of concentration of total sodium and potassium in surface and ground water using a flame photometer." Applied Water Science. 2020; 10:113. https://doi.org/10.1007/s13201-020-01188-1
3. Joshi RS, Bhandari P, Sangle D. "Application of hydrophobic solubilization technique for simultaneous estimation and validation of ofloxacin and ornidazole in tablet dosage form." Der Pharma letter. 2015; 7(11): 234-240.
4. Joshi RS, Nangare AK, Sanap DS and. Sase SM. "Development and Validation of UV-Spectrophotometric Method for Estimation of Metformin Hydrochloride and Pioglitazone in Tablet Dosage Form." Journal of Drug Delivery & Therapeutics. 2019; 9(4-A): 381-384. https://doi.org/10.22270/jddt.v9i4-A.3499
5. Beckett AH and Stenlake JB. "Practical Pharmaceutical Chemistry" Fourth Edition. CBS Publishers and Distributors New Delhi. 2001; Part Two: 275-337.
6. Joshi RS, Pund R, Kadam A. "Quantitative estimation and validation of ofloxacin and ornidazole in tablet dosage form by hydrotropic solubilization phenomenon", Der Pharma letter. 2016; 8(6): 269-274.
Published
Abstract Display: 92
PDF Downloads: 132
PDF Downloads: 16 How to Cite
Issue
Section
Copyright (c) 2025 Rupali S. Joshi, Shruti G. Dhere, Abhijeet H. Dhage, Sarthak B. Dhumal, Atharva A. Deshpande, Komal B. Dhakane, Shivani S. Devkate

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

.