FORMULATION AND EVALUATION OF GASTRO RETENTIVE EFFERVESCENT FLOATING MATRIX TABLETS OF CEPHALEXIN

Abstract

The present research work was an attempt to formulate and evaluate gastro retentive buoyant drug delivery system containing cephalexin in the form of tablets prepared by direct compression method by using the hydrophilic polymers such as HPMC K4M, HPMC K100M, Xanthan gum, Guar gum, Karaya gum, Sodium cmc and hydrophobic polymers ( Ethyl cellulose) . Both grades of HPMC were used individually in different ratios and remaining polymers were used in combination with both HPMC polymers. Sodium bicarbonate & citric acid, MCC were also used. The prepared tablets were evaluated for their Pre & Post compression parameters such as weight variation, thickness, hardness, friability, drug content, swelling index, in vitro buoyancy , in vitro drug release studies. All formulations followed first order kinetics, showed good correlation in higuchi kinetics indicating drug release was predominantly diffusion controlled. When data was fitted to peppas slope values suggest that release followed non fickian diffusion.

KEY WORDS: Cephalexin, HPMC K15M, HPMC K100M, Xanthan gum.