Therapeutic Potential of Ustukhuddus (Lavandula stoechas L.): The ‘Broom of the Brain’ in Unani Medicine and Neuropharmacology

Authors

  • Jahan Najeeb Professor and PhD Research Scholar, Dept. of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Bangalore, India.
  • Parwej Ahmad P.G scholar, Dept of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Bangalore, Karnataka, India.
  • Saima Bano P.G scholar, Dept of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Bangalore, Karnataka, India.
  • Nasreen Jahan Professor, Department of Ilmul Advia, National Institute of Unani Medicine, Bangalore, India
  • KMY Amin Professor, Dept. of Pharmacology (Retired), Faculty of Unani Medicine, Aligarh Muslim University, India.

Abstract

Objective(s): To evaluate the therapeutic significance of Ustukhuddus (Lavandula stoechas L.) in Unani medicine, focusing on its role as a brain tonic, phlegm expeller, and nervine stimulant, with particular emphasis on its ability to eliminate Saudawi (black bile) and Balghami (phlegmatic) morbid matters from the brain.

Data Sources: This study is based on a comprehensive review of classical Unani texts, including Al-Qanoon fi al-Tibb, Kitab al-Hawi, and Al-Jamiʿ li-Mufradat al-Adwiyah, and on modern scientific databases such as PubMed, Scopus, and Google Scholar, to assess phytochemical composition and pharmacological studies on Lavandula stoechas.

Study Selection: Relevant literature was selected to highlight the traditional uses of Ustukhuddus in Unani medicine and to evaluate contemporary pharmacological evidence supporting its therapeutic actions, particularly on the central nervous system.

Summary: Unani literature documents the use of Ustukhuddus for neurological conditions, including paralysis, epilepsy, melancholia, mania, anxiety, numbness, tremors, convulsions, and chronic headaches. Modern research corroborates these uses by demonstrating the antioxidant, anti-inflammatory, neuroprotective, antidepressant, anti-spasmodic, sedative, analgesic, and anticonvulsant activities. Major phytoconstituents such as linalool, flavonoids, and phenolic compounds contribute significantly to these effects.

Conclusion: The integration of traditional knowledge with modern pharmacological evidence supports Ustukhuddus as a promising neurotherapeutic agent. Its inclusion in evidence-based Unani formulations may offer valuable potential for managing neurological disorders, warranting further clinical validation.

Keywords: Ustukhuddus; Lavandula stoechas; Unani medicine; Jarūb-i-Dimāgh; Broom of the brain; Neuroprotective.

Keywords:

Ustukhuddus, Lavandula stoechas, Unani medicine, Jarūb-i-Dimāgh, Broom of the brain, Neuroprotective

DOI

https://doi.org/10.22270/jddt.v15i10.7412

Author Biographies

Jahan Najeeb , Professor and PhD Research Scholar, Dept. of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Bangalore, India.

Professor and PhD Research Scholar, Dept. of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Bangalore, India.

Parwej Ahmad , P.G scholar, Dept of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Bangalore, Karnataka, India.

P.G scholar, Dept of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Bangalore, Karnataka, India.

Saima Bano , P.G scholar, Dept of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Bangalore, Karnataka, India.

P.G scholar, Dept of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Bangalore, Karnataka, India.

Nasreen Jahan , Professor, Department of Ilmul Advia, National Institute of Unani Medicine, Bangalore, India

Professor, Department of Ilmul Advia, National Institute of Unani Medicine, Bangalore, India

KMY Amin , Professor, Dept. of Pharmacology (Retired), Faculty of Unani Medicine, Aligarh Muslim University, India.

Professor, Dept. of Pharmacology (Retired), Faculty of Unani Medicine, Aligarh Muslim University, India.

References

1. Anonymous. Ayurveda Pharmacopoeia of India, Part-1. Ministry of Health and Family Welfare, Govt. of India; 1986.

2. Ez zoubi Y, Bousta D, Farah A. A Phytopharmacological review of a Mediterranean plant: Lavandula stoechas L. Clinical Phytoscience. 2020; 6:9. https://doi.org/10.1186/s40816-019-0142-y

3. Upson TM, Jury SL. A revision of native Moroccan species of Lavandula L. section Pterostoechas Ging. (Lamiaceae). Taxon. 2002; 51:309-27. https://doi.org/10.2307/1554900

4. Gallotte P, Fremondière G, Gallois P, Bernier JPB, Buchwalder A, Walton A, et al. Lavandula angustifolia mill. And Lavandula x intermedia emeric ex loisel: lavender and lavandin. In: Medicinal, Aromatic and Stimulant Plants. Springer; 2020. p. 303-11. https://doi.org/10.1007/978-3-030-38792-1_6

5. Anonymous. National Formulary of Unani Medicine, Part-1. Ministry of Health and Family Welfare, Govt. of India; 1998.

6. Ghani N. Khazinul Advia. Edition 3rd. New Delhi: Idara Kitab-ul-shifa; 2011: 45, 59, 226, 227, 306, 348, 362, 479, 596, 683, 768, 1361.

7. Kalam MA, Husain Z, Haseeb A, Husain S, Shah K, Saleem B. Ustukhuddus (Lavandula stoechas L.): A boon for the management of neuropsychiatric disorders in perspective of Unani medicine-a review. Acta Scientific Pharmaceutical Sciences (ISSN: 2581-5423). 2021;5. https://doi.org/10.31080/ASPS.2021.05.0673

8. Wells R, Truong F, Adal AM, Sarker LS, Mahmoud SS. Lavandula essential oils: a current review of applications in medicinal, food, and cosmetic industries of lavender. Natural Product Communications. 2018; 13:1934578X1801301038. https://doi.org/10.1177/1934578X1801301038

9. Siddiqui M, Khalid M, Akhtar J, Siddiqui H, Ahmad U, Ahsan F, et al. Lavandula stoe-chas (Ustukhuddus): A miracle plant. J Innov Pharm Biol Sci. 2016; 3:96-102.

10. Lim TK. Edible medicinal and non-medicinal plants, Vol. 8. Springer; 2014. https://doi.org/10.1007/978-94-017-8748-2

11. Khan A. Mohit-e- Azam. Vol 1. New Delhi: CCRUM; 2012. 82, 290, 307, 500, 642, 646, 626.

12. Ibne Baitar A. Al-Jami'li-Mufradat al-Advia wa'l-Aghziyah. New Delhi (IN): Central Council for Research in Unani Medicine (CCRUM); 1985.

13. Sena I, Al Qanoon (Urdu Translation by Kantoori Gh). New Delhi: Idara Kitab-Ul-Shifa;2007. 137, 237, 272, 280, 291, 298, 327, 428, 437.

14. Halim MA. Mufradat-e-Azizi. New Delhi: CCRUM; 2009. 13, 14, 33, 47.

15. Khare CP. Indian Medicinal Plants: An Illustrated Dictionary. New Delhi: Springer (India) Pvt. Ltd; 2007. 320, 336, 365. https://doi.org/10.1007/978-0-387-70638-2 PMCid:PMC2705749

16. Kabir U. Makhzanul Mufradat. New Delhi: Idara Kitab-ul- shifa; 2007. 14, 67, 88, 108, 133, 134, 140 184, 215, 242.

17. Standardisation of single drugs of Unani medicine. Part II. New Delhi: Central Council for Research in Unani Medicine, Ministry of Health and Family Welfare, Government of India; 1987. 116, 282, 301, 306, 245.

18. Ibn Sina. Al-Qanoon fil Tib. Urdu Trans. by Kantoori GH. New Delhi: Idara Kitabus Shifa; 2007. Vol. 2, p. 277.

19. Khan Azam. Moheet-e-Azam. New Delhi: Central Council for Research in Unani Medicine; 2012. Vol. 1, pp. 30, 307.

20. Kabiruddin HM. Makhzanul Mufradat. New Delhi: Idara Kitabus Shifa; 2014. p. 67.

21. Basch E, Foppa I, Liebowitz R, Nelson J, Smith M, Sollars D, et al. Lavender (Lavandula angustifolia miller). Journal of herbal pharmacotherapy. 2004; 4:63-78. https://doi.org/10.1080/J157v04n02_07

22. IbnBaitar. Al Jami al-Mufradatul Advia wal Aghzia Vol I. New Delhi: CCRUM;1985. 54, 214.

23. Kabeeruddin M. Ilmul Advia Nafisi. New Delhi: Ejaz Publication House; 2007. 64, 174, 255.

24. Almaseehi IQ. Kitabul Umdah Fil Jarahat. 22nd ed. New Delhi: CCRUM. YNM; 234, 627.

25. Safi-Uddin. Unani Adviya Mufrrada. 10th ed. New Delhi Qaumi council barai farog urdu zaban; 1979. 32, 57, 73, 99, 106. 10th ed. New Delhi: Qaumi council barai farog urdu zaban; 1979.

26. Kabeeruddin M. Ilmul Advia Nafisi. New Delhi: Ejaz Publication House; 2007. 64, 174, 255.

27. Razi ABZ. Kitab al-Hawi fi al-Tibb [Urdu Trans: Tarjuma Kitab al-Hawi]. Vol. 2. New Delhi: CCRUM; 1999. p. 672.

28. Benali T, Lemhadri A, Harboul K, Chtibi H, Khabbach A, Jadouali SM, et al. Chemical profiling and biological properties of essential oils of lavandula stoechas L. Collected from three Moroccan sites: in vitro and in silico investigations. Plants. 2023; 12:1413. https://doi.org/10.3390/plants12061413 PMid:36987101 PMCid:PMC10057000

29. Domingues J, Delgado F, Gonçalves JC, Zuzarte M, Duarte AP. Mediterranean lavenders from section Stoechas: An undervalued source of secondary metabolites with pharmacological potential. Metabolites. 2023; 13:337. https://doi.org/10.3390/metabo13030337 PMid:36984777 PMCid:PMC10054607

30. Elrherabi A, et al. Frontiers in Pharmacology. 2024;1443311 - Aqueous extract phenolics (naringin, syringic, cinnamic acids). frontiersin.org+11frontiersin.org+11ouci.dntb.gov.ua+11 .

31. Aboalhaija N, et al. Chem Biodivers. 2025;28.7% rosmarinic acid; antiproliferative IC₅₀ 22-94 µg/mL. ouci.dntb.gov.ua+3pubmed.ncbi.nlm.nih.gov+3researchgate.net+3

32. Barkat M, Laib I. Antioxidant activity of the essential oil from the flowers of Lavandula stoechas. J Pharmacogn Phytother. 2012; 4:96-101. https://doi.org/10.5897/JPP12.030

33. Dob T, Dahmane D, Agli M, Chelghoum C. Essential oil composition of Lavandula stoechas. from Algeria. Pharmaceutical biology. 2006; 44:60-4. https://doi.org/10.1080/13880200500496421

34. Zuzarte M, Gonçalves M, Cavaleiro C, Cruz M, Benzarti A, Marongiu B, et al. Antifungal and anti-inflammatory potential of Lavandula stoechas and Thymus herba-barona essential oils. Industrial Crops and Products. 2013; 44:97-103. https://doi.org/10.1016/j.indcrop.2012.11.002

35. Zrira S, Benjilali B. The constituents of the oils of Lavandula stoechas L. ssp. atlantica Br.-Bl. and L. stoechas ssp. stoechas from Morocco. Journal of Essential Oil Research. 2003; 15:68-9. https://doi.org/10.1080/10412905.2003.9712066

36. Taoufik F, Hamdouch A, Zine S, Chebli B, El HADEK M, IDRISSI LMH. Essential Oil Content, Chemical Composition, Antioxidant Activity and Antiviral Potential against COVID-19 of Four Aromatic and Medicinal Plants from South of Morocco. Arabian Journal of Medicinal and Aromatic Plants. 2022; 8:77-93.

37. Rathore S, Kumar R. Essential oil content and compositional variability of Lavandula species cultivated in the mid hill conditions of the western himalaya. Molecules. 2022; 27:3391. https://doi.org/10.3390/molecules27113391 PMid:35684332 PMCid:PMC9182314

38. Sriti J, Fares N, Msaada K, Zarroug Y, Boulares M, Djebbi S, et al. Phenological stage effect on phenolic composition, antioxidant, and antibacterial activity of Lavandula stoechas extract. Rivista Italiana delle Sostanze Grasse. 2022;99.

39. Giray ES, Kırıcı S, Kaya DA, Türk M, Sönmez Ö, Inan M. Comparing the effect of sub-critical water extraction with conventional extraction methods on the chemical composition of Lavandula stoechas. Talanta. 2008; 74:930-5. https://doi.org/10.1016/j.talanta.2007.07.040 PMid:18371730

40. Raina AP, Negi K. Comparative essential oil composition of Lavendula species from India. Journal of herbs, spices & medicinal plants. 2012; 18:268-73. https://doi.org/10.1080/10496475.2012.690142

41. Sarri M, Mouyet FZ, Benziane M, Cheriet A. Traditional use of medicinal plants in a city at steppic character (M'sila, Algeria). Journal of Pharmacy & Pharmacognosy Research. 2014; 2:31-5. https://doi.org/10.56499/jppres14.019_2.2.31

42. Skoula M, Abidi C, Kokkalou E. Essential oil variation of Lavandula stoechas L. ssp. stoechas growing wild in Crete (Greece). Biochemical Systematics and Ecology. 1996; 24:255-60. https://doi.org/10.1016/0305-1978(96)00023-3

43. Naghibi F, Mosadegh M, Mohammadi MS, Ghorbani A. Labiatae family in folk medicine in Iran: from ethnobotany to pharmacology. 2005;

44. El-Hilaly J, Hmammouchi M, Lyoussi B. Ethnobotanical studies and economic evaluation of medicinal plants in Taounate province (Northern Morocco). Journal of ethnopharmacology. 2003; 86:149-58. https://doi.org/10.1016/S0378-8741(03)00012-6 PMid:12738079

45. Gilani A, Aziz N, Khan M, Shaheen F, Jabeen Q, Siddiqui B, et al. Ethnopharmacological evaluation of the anticonvulsant, sedative and antispasmodic activities of Lavandula stoechas L. Journal of Ethnopharmacology. 2000; 71:161-7. https://doi.org/10.1016/S0378-8741(99)00198-1 PMid:10904159

46. Camejo-Rodrigues J, Ascensao L, Bonet MÀ, Valles J. An ethnobotanical study of medicinal and aromatic plants in the Natural Park of "Serra de São Mamede" (Portugal). Journal of Ethnopharmacology. 2003; 89:199-209. https://doi.org/10.1016/S0378-8741(03)00270-8 PMid:14611883

47. Novais MH, Santos I, Mendes S, Pinto-Gomes C. Studies on pharmaceutical ethnobotany in Arrábida natural park (Portugal). Journal of ethnopharmacology. 2004; 93:183-95. https://doi.org/10.1016/j.jep.2004.02.015 PMid:15234752

48. Tardío J, Pardo-de-Santayana M, Morales R. Ethnobotanical review of wild edible plants in Spain. Botanical journal of the Linnean society. 2006; 152:27-71. https://doi.org/10.1111/j.1095-8339.2006.00549.x

49. Polat R, Satıl F. An ethnobotanical survey of medicinal plants in Edremit Gulf (Balıkesir-Turkey). Journal of Ethnopharmacology. 2012; 139:626-41. https://doi.org/10.1016/j.jep.2011.12.004 PMid:22193175

50. Anti-epileptogenic - Thesis Paper [unpublished]; cited in: Kalam MA. Ustukhuddus (Lavandula stoechas L.): A Boon... Acta Sci Pharm Sci. 2021;5(3):02-09. https://doi.org/10.31080/ASPS.2021.05.0673

51. Yassine EZ, Dalila B, Latifa EM, Smahan B, Lebtar S, Sanae A, et al. Phytochemical screening, anti-inflammatory activity and acute toxicity of hydro-ethanolic, flavonoid, tannin and mucilage extracts of Lavandula stoechas L. from Morocco. Int J Pharm Phytochem Res. 2016; 8:31-7.

52. Algieri F, Rodriguez-Nogales A, Vezza T, Garrido-Mesa J, Garrido-Mesa N, Utrilla MP, et al. Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L. Journal of ethnopharmacology. 2016; 190:142-58. https://doi.org/10.1016/j.jep.2016.05.063 PMid:27269390

53. Messaoud C, Chograni H, Boussaid M. Chemical composition and antioxidant activities of essential oils and methanol extracts of three wild Lavandula L. species. Natural product research. 2012; 26:1976-84. https://doi.org/10.1080/14786419.2011.635343 PMid:22117129

54. Apak R, Güçlü K, Özyürek M, Karademir SE. Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. Journal of agricultural and food chemistry. 2004; 52:7970-81. https://doi.org/10.1021/jf048741x PMid:15612784

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2025-10-15
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How to Cite

1.
Najeeb J, Ahmad P, Bano S, Jahan N, Amin K. Therapeutic Potential of Ustukhuddus (Lavandula stoechas L.): The ‘Broom of the Brain’ in Unani Medicine and Neuropharmacology. J. Drug Delivery Ther. [Internet]. 2025 Oct. 15 [cited 2025 Nov. 10];15(10):265-71. Available from: https://jddtonline.info/index.php/jddt/article/view/7412

How to Cite

1.
Najeeb J, Ahmad P, Bano S, Jahan N, Amin K. Therapeutic Potential of Ustukhuddus (Lavandula stoechas L.): The ‘Broom of the Brain’ in Unani Medicine and Neuropharmacology. J. Drug Delivery Ther. [Internet]. 2025 Oct. 15 [cited 2025 Nov. 10];15(10):265-71. Available from: https://jddtonline.info/index.php/jddt/article/view/7412