A Comprehensive Literary Review of Bronchial Asthma (Zīq-Un-Nafas Shu‘Bī) and its Management in the Unani System of Medicine
Abstract
Lung diseases are among the leading global health concerns, affecting more than 500 million people and accounting for nearly 10% of annual deaths. Asthma, derived from the Greek verb aazein meaning “to pant,” was first mentioned in Homer’s Iliad and later recognized in the Corpus Hippocraticum as a medical condition. Initially used for general breathlessness, it was more clearly defined in the 19th century by Henry Hyde Salter as a disorder characterized by episodic breathing difficulty due to airway narrowing. In the Unani System of Medicine (USM), asthma is classified under Amrāḍ-i-Majāri (respiratory disorders). This paper explores the Unani perspective of bronchial asthma through classical references and modern research. Literature search included classical texts such as Al-Qanoon, Kitab al-Hawi, Zakhira Thabit bin Qara, Kulliyat, and Tibbe Akbar, along with modern databases (PubMed, Google Scholar, Science Direct, Web of Science, and Scopus). A total of 23 classical Unani books, 18 original research articles, and 34 review articles were reviewed. Scholars like Buqrat, Jalinus, Razi and Ibn Sina described asthma as Rabw, Buhr, and, Ḍῑq al-Nafas, and recommended single drugs (Adusa, Aslussus, Banafsha, Afteemoon, Unnab) and compound formulations (Sharbat-e-Banafsha, Sharbat-e-Ejaz, Sharbat-e-Unnab, Safoof-e-Dama). The collected data were analysed and systematically organized to highlight the relevance of Unani approaches in asthma management.
Keywords: Amrāḍ-I-Majari, Ḍῑq al-Nafas, Asthma, lung disease, Rabw, USM
Keywords:
Amrāḍ-I-Majari, Ḍῑq al-Nafas, Asthma, lung disease, Rabw, USMDOI
https://doi.org/10.22270/jddt.v15i10.7401References
1. World Health Organization. Asthma [Internet]. Geneva: World Health Organization; 2023 [cited 2025 May 12]. Available from: https://www.who.int/news-room/fact-sheets/detail/asthma
2. Sakula A. Henry Hyde Salter (1823-71): A biographical sketch. Thorax. 1985;40(12):887-8. https://doi.org/10.1136/thx.40.12.887 PMid:3913047 PMCid:PMC460219
3. James SL, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018 Nov 10;340(10112):1789-858.
4. Institute for Health Metrics and Evaluation (IHME). Global Burden of Disease Study 2019 (GBD 2019) Results [Internet]. Seattle, WA: IHME, University of Washington; 2020. Available from: https://vizhub.healthdata.org/gbd-results/
5. World Health Organization. Asthma [Internet]. Geneva: WHO; 2023 Available from: https://www.who.int/news-room/fact-sheets/detail/asthma
6. Singh S, Salvi S, Mangal DK, et al. Prevalence, time trends and treatment practices of asthma in India: The Global Asthma Network study. ERJ Open Res. 2022;8(2):00528-2021. https://doi.org/10.1183/23120541.00528-2021 PMid:35651368 PMCid:PMC9149387
7. Osler W. The Principles and Practice of Medicine. 1st ed. New York: D. Appleton and Company; 1840. p. 112-505.
8. Anonymous, WHO international standard terminologies on Unani medicine, Department of Integrated Health Services World Health Organization (WHO), Geneva, 2022; 253.
9. Azhar MU, Mustehasan, Adhami SM, Siddiqui KM, Khan MA, Ahmad MN. Clinical Study of A Polyherbal Unani Formulation in Ḍῑq al-Nafas (Bronchial Asthma), CCRUM publication New Delhi, 2014; 7-10.
10. Razi ABMBZ. Kitab al-Hawi (Urdu translation by CCRUM) Vol.4th. New Delhi: CCRUM; 2008 p: 75-77
11. Sina 1. Al-Qanoon fil Tibb (Urdu translation by Kantoori GH) Vol.1. New Delhi: Idara Kitabul Shifa; 2010 p: 201-205
12. Arzani A. Tibb-i-Akbar [Husain M, trans]: New Delhi: Idara Kitab-us- Shifa; 2015 p 198
13. Edmund I. Herney, M.D., La Jolla, Caliy. Edmund L. Keeney M.D.
14. J. Tod Olin,36 - Exercise-Induced Asthma: Strategies to Improve Performance, Editor(s): Donald Y.M. Leung, Stanley J. Szefler, Francisco A. Bonilla, Cezmi A. Akdis, Hugh A. Sampson, Pediatric Allergy: Principles and Practice (Third Edition), Elsevier, 2016, Pages336-342.e2, ISBN 9780323298712, https://doi.org/10.1016/B978-0-323-29875-9.00036-7
15. Khan MA. Ikseer Azam [Kabiruddin M, trans]. New Delhi: Idara Kitabus Shifa; 2011 p 337
16. Razi ABMBZ. Kitab al-Hawi (Urdu translation by CCRUM) Vol.4th. New Delhi: CCRUM; 2008 p 75-77
17. Sina I. Al-Qanoon fil Tibb (Urdu translation by Kantoori GH) Vol.1. New Delhi: Idara Kitabul Shifa; 2010. P 227
18. Jurjani I. Zakhira Khwarizam Shahi (Urdu Translation by H.H. Khan).New Delhi: Idara Kitabul Shifa; 2010 p: 324
19. Majoosi IA. Kamilus-Sana'ah [Kantoori GH, trans]. New Delhi: Idara Kitabus Shifa; 2010 p 179
20. Khan MA. Ikseer Azam [Kabiruddin M, trans]. New Delhi: Idara Kitabus Shifa; 2011 p 277
21. (Razi ABMBZ. Kitab al-Hawi) Vol.1. New Delhi: CCRUM; 2005 p 75-77
22. Baghdadi AI. Kitabal-Mukhtärät fi'I Tibb (Urdu translation by Central Council for Research in Unani Medicine). Vol.1. New Delhi: CCRUM; 2005 p 98-91
23. Al-Tabari AABSR. Firdaus-ul-Hikmat [Shah MA, trans]. New Delhi: Idara Kitabus Shifa; 2010 p 210
24. Tabri ABM, Al Molijat-i-buqratiya [CCRUM] V 1 New Dehi: CCRUM: 1995 p 130
25. Anonymous. Amraz-e-Riya. New Delhi: CCRUM; 1995 p 37
26. Razi ABMBZ. Kitab al-Hawi (Urdu translation by CCRUM) Vol.4th. New Delhi: CCRUM; 2008. P 75-77
27. Arzani A. Tibb-i-Akbar [Husain M, trans]: New Delhi: Idara Kitab-us- Shifa; 2015 p 221
28. Khan MA. Ikseer Azam [Kabiruddin M, trans]. New Delhi: Idara Kitabus Shifa; 2011 p 303
29. Razi IZ. Kitab al-Mansoori. [Central Council for Research in Unani Medicine, trans]. New Delhi: CCRUM; 1991. P. 351
30. Ibn Rushd AW. Kitabul Kulliyat. (Urdu Translation). Lahore: Maktaba Daniyal; 2017 p 265
31. Bhat MDA, Khan AB, Hakim MH. Unani Aspect of Cardiac Arrhythmia- A Review. Indian
32. Jalinoos. Kitab Fi Firaq Al-Tib (Urdu Translation by Rahman HSZ). Aligarh:Ibn Sina Academy; 2008 p 16
33. AMH. Ghina Muna (Urdu translation). New Delhi: CCRUM; 2008 p 234
34. Manniche L. Sacred luxuries: fragrance, aromatherapy, and cosmetics in ancient Egypt. Cornell University Press; 1999.
35. Patwa A, Shah A. Anatomy and physiology of respiratory system relevant to anesthesia. Indian J Anaesth. 2015 Sep;59(9):533-41. https://doi.org/10.4103/0019-5049.165849 PMid:26556911 PMCid:PMC4613399
36. Razi AHF. Ilmul-akhlaq [Masumi MSH, trans]. New Delhi: Kitab bhawan; 1978
37. Kabiruddin M. Tarjuma Kabir, part-2, Matba Daftarul Maseeh. Delhi; 1933. 557-58,71.
38. Razi AMBZ. Kitabul Fakhir Fit Tib (Urdu Translation by CCRUM) Vol. 1. New Delhi: CCRUM Ministry of H&FW; 2008.
39. Lopez K, Whitehead L. Communication in Palliative Care [Internet]. Brisbane (AU): Exon Publications; 2018. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470401
40. Kasper D, Fauci A, Hauser S, Longo D, Jameson J, Loscalzo J. Harrison's principles of internal medicine, 19e. Vol. 1. McGraw-Hill New York, NY, USA:; 2015.
41. Paliwa JK, Dwivedi AK, Singh S, Gutpa RC. Pharmacokinetics and in-situ absorption studies of a new antiallergic compound 73/602 in rats. International journal of pharmaceutics. 2000 Mar 20;197(1-2):213-20. https://doi.org/10.1016/S0378-5173(00)00324-0 PMid:10704808
42. Athiya V, Gupta S, Chourasiya A. Phytochemical Screening and Assessment of Adhatoda Vasica (Leaf) For Antihistaminic Activity. Journal of Drug Delivery and Therapeutics. 2019 Dec 19;9(4-s):1092-5.
43. Saran N, Anandharaj B, Bupesh G, Vasanth S, Surendhar PA. In vitro antioxidant potential of Justicia adhatoda leaf extracts against 1, 1-diphenyl picryl hydrazyl, hydroxyl, and nitrous oxide free radicals. Drug Invention Today. 2019 Aug 15;12(8):1736-40.
44. Khan HMA. Muhit-i-Azam. New Delhi: Central Council for Research in Unani Medicine (CCRUM); 2012. Vol I-III p. 547
45. Geetha T, Varalakshmi P. Anti-inflammatory activity of lupeol and lupeol linoleate in rats. Journal of ethnopharmacology. 2001 Jun 1;76(1):77-80. https://doi.org/10.1016/S0378-8741(01)00175-1 PMid:11378285
46. Khan AU, Gilani AH. Natural Products Useful in Respiratory Disorders: Focus on Side‐Effect Neutralizing Combinations. Phytotherapy Research. 2015 Sep;29(9):1265-85. https://doi.org/10.1002/ptr.5380 PMid:26061992
47. Ali B, Mujeeb M, Aeri V, Mir SR, Faiyazuddin M, Shakeel F. Anti-inflammatory and antioxidant activity of Ficus carica Linn. Leaves. Natural product research. 2012 Mar 1;26(5):460-5. https://doi.org/10.1080/14786419.2010.488236 PMid:21644169
48. Yang XM, Yu W, Ou ZP, Ma HL, Liu WM, Ji XL. Antioxidant and immunity activity of water extract and crude polysaccharide from Ficus carica L. fruit. Plant Foods for Human Nutrition. 2009 Jun;64(2):167-73. https://doi.org/10.1007/s11130-009-0120-5 PMid:19466553
49. Khare CP. Indian Medicinal Plants: An Illustrated Dictionary. Berlin: Springer; 2008. https://doi.org/10.1007/978-0-387-70638-2 PMCid:PMC2705749
50. Boskabady MH, Ramazani-Assari M. Relaxant effect of Pimpinella anisum on isolated guinea pig trachea. J Ethnopharmacol. 2001;74(1):83-8. https://doi.org/10.1016/S0378-8741(00)00314-7 PMid:11137352
51. Singh SK, Patel JR, Dubey PK, Thakur S. A review on anti-asthmatic activity of traditional medicinal plants. International journal of pharmaceutical sciences and research. 2014 Oct 1;5(10):4097.
52. Lee YM, Kim DK, Kim SH, et al. Antianaphylactic activity of Poncirus trifoliata fruit extract. J Ethnopharmacol. 1996;54(2-3):77-84. https://doi.org/10.1016/S0378-8741(96)01451-1 PMid:8953421
53. Kabir HM. Makhzan-ul Mufradat al-Ma'ruf Khawas-ul Advia. Deoband: Faisal Publishers; 2000. P 232
54. Huber R, Stintzing FC, Briemle D, Beckmann C, Meyer U, Gründemann C. In vitro antiallergic effects of aqueous fermented preparations from Citrus and Cydonia fruits. Planta Medica. 2012 Mar;78(04):334-40. https://doi.org/10.1055/s-0031-1280455 PMid:22193979
55. Janbaz KH, Shabbir A, Mehmood MH, Gilani AH. Insight into mechanism underlying the medicinal use of Cydonia oblonga in gut and airways disorders. J Anim Plant Sci. 2013 Jan 1;23:330-6.
56. Miraj S, Kiani S. Study of antibacterial, antimycobacterial, antifungal, and antioxidant activities of Foeniculum vulgare: A review. Der Pharmacia Lettre. 2016;8(9):200-5.
57. Ma C, Ma Z, Fu Q, Ma S. Curcumin attenuates allergic airway inflammation by regulation of CD4+ CD25+ regulatory T cells (Tregs)/Th17 balance in ovalbumin-sensitized mice. Fitoterapia. 2013 Jun 1; 87:57-64. https://doi.org/10.1016/j.fitote.2013.02.014 PMid:23500387
58. Karaman M, Firinci F, Cilaker S, et al. Anti-inflammatory effects of curcumin in chronic asthma (murine). Allergol Immunopathol (Madr). 2012;40(4):210-4. https://doi.org/10.1016/j.aller.2011.04.006 PMid:21862198
59. Khan IA, Aziz A, Munawar SH, Manzoor Z, Afzal A. Evaluation of Counter Irritant Potential of Aqueos Bark Extract of Cinnmon Loureiroi. Int J Pharm Res Allied Sci. 2014; 3:30-5.
60. Pel P, Kim YM, Chin YW. Chemical Constituents with Antiallergic Activity from the Barks of Cinnamomum cambodianum Collected in Cambodia. Bulletin of the Korean Chemical Society. 2015 Jan;36(1):384-7. https://doi.org/10.1002/bkcs.10022
61. Asadi-Samani M, Bahmani M, Rafieian-Kopaei M. The chemical composition, botanical characteristic and biological activities of Borago officinalis: a review. Asian Pacific journal of tropical medicine. 2014 Sep 1;7: S22-8. https://doi.org/10.1016/S1995-7645(14)60199-1 PMid:25312125
62. Rao YK, Geethangili M, Fang SH, Tzeng YM. Antioxidant and cytotoxic activities of naturally occurring phenolic and related compounds: a comparative study. Food and Chemical Toxicology. 2007 Sep 1;45(9):1770-6. https://doi.org/10.1016/j.fct.2007.03.012 PMid:17475387
63. Liu Y, Kakani R, Nair MG. Compounds in functional food fenugreek spice exhibit anti-inflammatory and antioxidant activities. Food Chemistry. 2012 Apr 15;131(4):1187-92. https://doi.org/10.1016/j.foodchem.2011.09.102
64. Gholamnejad Z, Byrami G, Boskabady MH, Iranshahi M. Possible mechanism (s) of the relaxant effect of asafoetida (Ferula assa-foetida) oleo-gum-resin extract on guinea-pig tracheal smooth muscle. 2012: 10-16
65. Benso B, Franchin M, Massarioli AP, Paschoal JA, Alencar SM, Franco GC, Rosalen PL. Anti-inflammatory, anti-osteoclastogenic and antioxidant effects of Malva sylvestris extract and fractions: in vitro and in vivo studies. PLoS One. 2016 Sep 19;11(9): e0162728. https://doi.org/10.1371/journal.pone.0162728 PMid:27643502 PMCid:PMC5028055
66. Afshar AA, Ghafarzade S, Yavari B, Athari SS. Survey the effect of Herbal Medicine on pathogenesis of Eosinophilic Chemotactic Factors in experimental Allergic Asthma. Adv Biores. 2014;5(1):160-4.
67. Shah SA, Akhtar N, Akram M, Shah PA, Saeed T, Ahmed K, Asif HM. Pharmacological activity of Althaea officinalis L. Journal of Medicinal Plants Research. 2011 Oct 30;5(24):5662-6.
68. Saleh S, El Denshary E, Mahran N. Nigella sativa (Black seed) oil: anti-inflammatory and antioxidant effects in experimental models of allergic asthma. InFirst USIM International Conference on Medicine and Health (ICMH2012), Kuala Lumpur. http://dx. doi. org/10.13140/2.1 2012 May (Vol. 3966).
69. Wu X, Xiao F, Zhang Z, Li X, Xu Z. Research on the analgesic effect and mechanism of bornyl acetate in volatile oil from Amomum villosum. Zhong yaocaiZhongyaocai Journal of Chinese medicinal materials. 2005 Jun 1;28(6):505-7.
70. Zanwar AA, Hegde MV, Bodhankar SL. In vitro antioxidant activity of ethanolic extract of Linum usitatissimum. Pharmacology online. 2010; 1:683 96.
71. Arora P, Ansari SH, Najmi AK, Anjum V, Ahmad S. Investigation of antiasthmatic potential of dried fruits of Vitis vinifera L. in animal model of bronchial asthma. Allergy, Asthma & Clinical Immunology. 2016 Dec;12(1):1 2. https://doi.org/10.1186/s13223-016-0145-x PMid:27536321 PMCid:PMC4988050
72. Choi MS, Do KM, Park YB, Jeon SM, Jeong TS, Lee YK, Lee MK, Bok SH. Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E. Annals of Nutrition and Metabolism. 2001;45(5):193-201. https://doi.org/10.1159/000046729 PMid:11585976
73. Sunkara Y, Robinson A, Babu KS, Naidu VG, Vishnuvardhan MV, Ramakrishna S, Madhavendra SS, Rao JM. Anti-inflammatory and cytotoxic activity of chloroform extract of roots of Saussurea lappa Clarke. Journal of Pharmacy Research. 2010;3(8):1775-8.
74. Al Bayaty MA. Mechanism of the tracheal smooth muscle relaxant activity of the Cordia myxa plant extract in sheep. The Iraqi Journal of Veterinary Medicine. 2008 Dec 31;32 (2):214-26. https://doi.org/10.30539/iraqijvm.v32i2.755
75. Hussain N, Kakoti BB, Rudrapal M, Sarwa KK. Anti-inflammatory and Antioxidant Activities of Cordia dichotoma Forst. Biomed. Pharmacol. J. 2020 Dec 1; 13:2093-9. https://doi.org/10.13005/bpj/2090
76. Rajanandh MG, Nageswari AD, Irshad PP, Ramasamy C. Does dose reduction of an inhaled corticosteroid with the addition of leukotriene antagonist is clinical significance in asthma patients. An aandomized clinical trial. World Appl Sci J. 2013; 24:276-81.
77. Aggarwal AN, Chaudhry K, Chhabra SK, D Souza GA, Gupta D, Jindal SK, Katiyar SK, Kumar R, Shah B, Vijayan VK. Prevalence and risk factors for bronchial asthma in Indian adults: a multicenter study. Indian Journal of Chest Diseases and Allied Sciences. 2006 Jan 18;48(1):13.
78. Makino T, Shiraki Y, Mizukami H. Interaction of gypsum and the rhizome of Anemarrhenaasphodeloides plays an important role in antiallergic effects of byakkokakeishito in mice. Journal of natural medicines. 2014 Jul;68(3):505 12. https://doi.org/10.1007/s11418-014-0827-y PMid:24554438 PMCid:PMC4353874
79. Vinaya M, Kamdod MA, Swamy M, Swamy M. Bronchodilator activity of Ocimum sanctum Linn. (Tulsi) in mild and moderate asthmatic patients in comparison with salbutamol: a single-blind cross-over study. Int J Basic Clin Pharmacol. 2017 Mar;6(3):511. https://doi.org/10.18203/2319-2003.ijbcp20170543
80. Singh S, Agrawal SS. Anti-asthmatic and anti-inflammatory activity of Ocimum sanctum. International Journal of pharmacognosy. 1991 Jan 1;29(4):306-10. https://doi.org/10.3109/13880209109082904
81. Arantes S, Candeias F, Lopes O, Lima M, Pereira M, Tinoco T, Cruz-Morais MJ. Martins R. Pharmacological and Toxicological Studies of Essential Oil of Lavandula stoechas subsp. Luisieri. Planta Med 2016; 82(14): 1266-1273 https://doi.org/10.1055/s-0042-104418 PMid:27124241
82. Naik SR, Bhagat S, Shah PD, Tare AA, Ingawale D, Wadekar RR. Evaluation of antiallergic and anti-anaphylactic activity of ethanolic extract of Zizyphus jujuba fruits in rodents. Revista Brasileira de Farmacognosia. 2013 Sep 1;23(5):811-8. https://doi.org/10.1590/S0102-695X2013000500014
83. Bashir S, Abbas S, Gilani AH, Khan A. Studies on bronchodilator and cardiac stimulant activities of Urginea indica. Bangladesh Journal of Pharmacology, 2013 May 20;8(3):249-54. https://doi.org/10.3329/bjp.v8i3.14825
84. Ma X, Ma X, Ma Z, Sun Z, Yu W, Wang J, Li F, Ding J. The Effects of Uygur Herb Hyssopus officinalis L. on the Process of Airway Remodeling in Asthmatic Mice", Evidence-Based Complementary and Alternative Medicine, vol. 2014, https://doi.org/10.1155/2014/710870 Mid:25383084 PMCid:PMC4212596
85. Ghayur MN, Gilani AH, Janssen LJ. Ginger attenuates acetylcholine-induced contraction and Ca2+ signaling in murine airway smooth muscle cells. Canadian journal of physiology and pharmacology. 2008 May;86(5):264-71. https://doi.org/10.1139/Y08-030 PMid:18432287
86. Tewtrakul S, Subhadhirasakul S. Anti-allergic activity of some selected plants in the Zingiberaceae family. Journal of ethnopharmacology. 2007 Feb 12;109(3):535-8. https://doi.org/10.1016/j.jep.2006.08.010 PMid:16978816
87. Anonymous. National Formulary of Unani Medicine. Part I. New Delhi: CCRUM, Ministry of Health & Family Welfare, Govt. of India; 2006.
88. Anonymous. National Formulary of Unani Medicine. Part III (1st ed.). New Delhi: Dept. of AYUSH, Ministry of Health & Family Welfare, Govt. of India; 2001.
89. Anonymous. National Formulary of Unani Medicine. Part V. New Delhi: Dept. of AYUSH, Ministry of Health & Family Welfare, Govt. of India; 2008.
90. Ahmed, N., Zakir, M. ., Alam, M. A., Javed, G., & Minhajuddin, A. (2022). Management of asthma (ḌĪQ Al-Nafas) in Unani system of medicine. International Journal of Health Sciences, 6(S1), 13036 13054. https://doi.org/10.53730/ijhs.v6nS1.8271
91. Chughmini MM. Khulasat al-Qanoon. Arabic Publisher Berut Lebanon: Al-balagh press; 2002. p. 103
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