EFFECT OF GEMCITABINE ON FEMALE FERTILTY – AN ANIMAL MODEL STUDY

  • Mohandas Rai Department of Pharmacology, A J Institute of Medical Sciences, Mangalore, India. PIN – 575004
  • Sudha M J Department of Pharmacology, Azeezia Institute of Medical Sciences, Kollam, India. PIN – 691537
  • Viveka S Department of Anatomy, Azeezia Institute of Medical Sciences, Kollam, India. PIN – 691537
  • Kumaraswamy Kademane International Medical University, Kuala Lumpur, Malaysia
  • Ashwini Mandanna Zydus Cadila, Ahemadabad, India PIN – 382210
  • Rashmi R Rao Department of Pharmacology Kasturba Medical College, Mangalore, India. PIN – 575001
  • Roopa P Nayak Department of Pharmacology, Dhanalakshmi Srinivasan Medical College, Perambalur, India
  • seethalakshmi C Department of Pharmacology, A J Institute of Medical Sciences, Mangalore, India. PIN – 575004

Abstract

Background and objectives: Advances in cancer chemotherapy have led to improved survival rates and poses greater emphasis on preserving quality of life post-treatment. Gonadotoxicity is a well-recognized side effect of many cancer chemotherapeutic agents. This study was designed to evaluate the effects of gemcitabine, an antimetabolite anticancer drug, on oogenesis in Swiss albino mice and its reversibility.

Methods: Thirty six inbred female Swiss albino mice in diestrous phase were selected and divided into three groups of twelve each. Groups were labelled as A, B and Control. Groups A and B received 40 mg/kg and 80 mg/kg of gemcitabine intraperitoneally. The control group received saline intraperitoneally. At the end of two weeks 6 mice were sacrificed from each group and the rest at the end of 2 months.  Ovaries were studied histologically.

Results: After 2 weeks, the ovaries of experimental group mice showed more number of atretic follicles as compared to control group (p<0.01). The diameter of corpus lutea was more, though a reduction in number was recorded in experimental group (p<0.05).  Whereas after 2 months, both the experimental groups showed no difference in terms of atretic follicles, diameter and number of corpus lutea (p>0.05).

Conclusions: These findings suggest that administration of gemcitabine may have profound effects on oogenesis and hence female fertility. This study also suggests that the effects are reversible.

Keywords: Gemcitabine; Oogenesis; Swiss albino mice; atretic follicles; corpus luteum.

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Author Biographies

Mohandas Rai, Department of Pharmacology, A J Institute of Medical Sciences, Mangalore, India. PIN – 575004

Professor & Head

Department of Pharmacology, A J Institute of Medical Sciences, Mangalore, India. PIN – 575004

 

Sudha M J, Department of Pharmacology, Azeezia Institute of Medical Sciences, Kollam, India. PIN – 691537

Assistant Professor

Department of Pharmacology, Azeezia Institute of Medical Sciences, Kollam, India. PIN – 691537

Viveka S, Department of Anatomy, Azeezia Institute of Medical Sciences, Kollam, India. PIN – 691537

Assistant Professor

Department of Anatomy, Azeezia Institute of Medical Sciences, Kollam, India. PIN – 691537

 

Kumaraswamy Kademane, International Medical University, Kuala Lumpur, Malaysia

Lecturer

International Medical University, Kuala Lumpur, Malaysia

Ashwini Mandanna, Zydus Cadila, Ahemadabad, India PIN – 382210

Medical Advisor

Zydus Cadila, Ahemadabad, India PIN – 382210

Rashmi R Rao, Department of Pharmacology Kasturba Medical College, Mangalore, India. PIN – 575001

Assistant Professor

Department of Pharmacology

Kasturba Medical College, Mangalore, India. PIN – 575001

Roopa P Nayak, Department of Pharmacology, Dhanalakshmi Srinivasan Medical College, Perambalur, India

Professor & Head

Department of Pharmacology, Dhanalakshmi Srinivasan Medical College, Perambalur, India

seethalakshmi C, Department of Pharmacology, A J Institute of Medical Sciences, Mangalore, India. PIN – 575004

Professor

Department of Pharmacology, A J Institute of Medical Sciences, Mangalore, India. PIN – 575004

 

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How to Cite
1.
Rai M, M J S, S V, Kademane K, Mandanna A, Rao R, Nayak R, C seethalakshmi. EFFECT OF GEMCITABINE ON FEMALE FERTILTY – AN ANIMAL MODEL STUDY. JDDT [Internet]. 8Jan.2014 [cited 29Jul.2021];4(1):45-8. Available from: https://jddtonline.info/index.php/jddt/article/view/737