Psoralea corylifolia L. (Babchi): A Comprehensive Review of Its Phytochemistry, Pharmacology and Ethnomedicinal Applications in the AYUSH (Unani) System of Medicine

Authors

  • Abdullah Assistant Professor Department of Ilmul Advia(Pharmacology) Deoband Unani Medical College Hospital& research Centre Deoband-247554
  • Yasmeen Khan Department of Ilmul Advia(Pharmacology) National Research Inistitute of Unani Medicie for Skin Disorders Hyderabad-500038
  • Labeeb Shaida Department of Ilmul Advia(Pharmacology) National Research Inistitute of Unani Medicie for Skin Disorders Hyderabad-500038
  • Abdul Kabeer M.D Scholar National Research Inistitute of Unani Medicine for Skin Disorders Hyderabad 500038
  • Mohd. Noman Taha Assistant Professor Department of Ilmul Advia Deoband Unani Medical College and Hospital 247554

Abstract

Psoralea corylifolia L., commonly known as Babchi, is a well-known medicinal plant that has been utilized for centuries in traditional medical systems such as Ayurveda, Siddha, and particularly the Unani system of medicine, where it is referred to as Babchi. Belonging to the Fabaceae family, P. corylifolia is native to tropical and subtropical regions, including China, South Africa, and extensively across the Indian subcontinent—namely Maharashtra, West Bengal, Uttar Pradesh, Rajasthan, Karnataka, Bihar, and the Deccan plateau.

In the Unani system, different parts of the plant are used therapeutically: roots for dental caries; leaves for diarrhoea; fruits for conditions such as anaemia, asthma, bronchitis, dysuria, inflammation, and vomiting; and seeds for skin conditions like scabies, ulcers, vitiligo, leucoderma, eczema, leprosy, and psoriasis. Phytochemical investigations have revealed more than seventy bioactive compounds, including flavonoids, coumarins, Quinone’s, phenols, benzofurans, benzopyrans, sesquiterpenoids, triterpenes, and steroids. Various pharmacological activities have been reported, such as anti-inflammatory, hepatoprotective, hemostatic, antioxidant, antimicrobial, antibacterial, antifungal, anti-obesity, antiviral, anti-mutagenic, anti-filarial, estrogenic, anticancer, anti-asthmatic, anti-diabetic, anti-aging, and immunomodulatory properties. Additionally, potential therapeutic effects have been observed in Alzheimer’s disease and alopecia areata.

Several traditional and proprietary Unani formulations such as Roghan Babchi, Sufoof-e-Babchi, Zimad-e-Bars, Habb-e-Bars, and Habb-e-Hindi are commercially available for therapeutic use. This review aims to consolidate classical Ethnomedicinal knowledge and recent pharmacological research on P. corylifolia to facilitate its broader integration into evidence-based phytomedicine.

Keywords. Psoralea corylifolia, Babchi, Dermatological disorders, Unani medicine.

Keywords:

Psoraliya corylifoliya, Babchi, vitiligo, unani medicine

DOI

https://doi.org/10.22270/jddt.v15i8.7318

Author Biographies

Abdullah, Assistant Professor Department of Ilmul Advia(Pharmacology) Deoband Unani Medical College Hospital& research Centre Deoband-247554

Assistant Professor Department of Ilmul Advia(Pharmacology) Deoband Unani Medical College Hospital& research Centre Deoband-247554

Yasmeen Khan , Department of Ilmul Advia(Pharmacology) National Research Inistitute of Unani Medicie for Skin Disorders Hyderabad-500038

M.D Scholar National Research Inistitute of Unani Medicine for Skin Disorders Hyderabad, Telangana 500038

Labeeb Shaida, Department of Ilmul Advia(Pharmacology) National Research Inistitute of Unani Medicie for Skin Disorders Hyderabad-500038

M.D Scholar National Research Inistitute of Unani Medicine for Skin Disorders Hyderabad 500038

Abdul Kabeer, M.D Scholar National Research Inistitute of Unani Medicine for Skin Disorders Hyderabad 500038

M.D Scholar National Research Inistitute of Unani Medicine for Skin Disorders Hyderabad 500038

Mohd. Noman Taha, Assistant Professor Department of Ilmul Advia Deoband Unani Medical College and Hospital 247554

Assistant Professor Department of Ilmul Advia Deoband Unani Medical College and Hospital 247554

References

1. Ansari S, Khan QA, Anjum R, Siddiqui A, Sultana K, European Journal of Biomedical and Pharmaceutical …, 2017 Fundamentals of Unani system of medicine-a review. http://www.ejbps.com/

2. Parveen A, Parveen R, Akhatar A, Parveen B, Siddiqui KM, Iqbal M. Concepts and quality considerations in Unani system of medicine. Journal of AOAC International. 2020;103(3):609-33. https://doi.org/10.5740/jaoacint.19-0284 PMid:31547901

3. Ahmad B, Akhtar J. Unani system of medicine. Pharmacogn Rev. 2007;1(2):210-14. http://www.phcogrev.com/

4. Khare CP. Indian Medicinal Plants: An Illustrated Dictionary. Springer; 2007.

5. Sharma PC, Yelne MB, Dennis TJ. Database on Medicinal Plants Used in Ayurveda. Vol. 4. CCRAS; 2001.

6. Singh G, Kumar S, Sharma P, Sharma AK. Phytochemical and pharmacological profile of Psoralea corylifolia L.: A review. J Appl Pharm Sci. 2017;7(10):239–245.

7. Patel D, Kumar R, Prasad SK, Hemalatha S. Psoralea corylifolia L.: An overview. J Ethnopharmacol. 2016;207:56–66.

8. Westerhof W, Nieuweboer-Krobotova L. Treatment of vitiligo with UV-B radiation vs topical psoralen plus UV-A. Arch Dermatol. 1997;133(12):1525–1528.

9. Misra N, Chandra D. Psoralea corylifolia seeds: A review. Int J Ayurveda Res. 2011;2(2):71–79.

10. The Ayurvedic Pharmacopoeia of India. Part I, Vol. I. Govt. of India, Ministry of Health & Family Welfare, Department of AYUSH; 1999.

11. Ghani HN. Khazain-ul- Advia. Idara Kitab-us-Shifa, Edn. 2005;1:316-317.

12. The Unani Pharmacopeia of India Part-1,Vol-1. Delhi: Dept. of AYUSH, Ministry of Health and Family Welfare, Govt. of India India; 2007. 11–12, 88–89 p

13. Tariq NA. Taj al-Mufradat. Idara Kitab-us-Shifa, 2075, Kucha Chelan, Darya Ganj; 2010. 39–41, 100,101, 638–39, 622–24, 535–36 p.

14. Abdul Hakeem HM. Bustanul Mufradat Jadeed. New Delhi.: Idara Kitab al Shifa; 2002. 109, 509–10, 598, 428–29p

15. Kabīruddin HM. Makhzan al-Mufridāt al-Mārūf khawas al-Advia. Delhi: CCRUM, Ministry of Health and Family Welfare, Govt. of India; 2007. 441, 442, 504, 505 p

16. Khan MA. Muhit-I-Azam, Urdu Translation. Vol. I, Central Council for Research in Unani Medicine, Ministry of Health and Family Welfare, New Delhi India. 2012. 213-510,512,513p.

17. Chopra B, Dhingra AK, Dhar KL. Psoralea corylifolia L. (Buguchi)—Folklore to modern Review. Fitoterapia. 2013;90:44-56. Evidence

18. Anonymous. The Wealth of India, Publications & Information Directorate (PID), CSIR, New Delhi, 1995; 8:296-298.

19. Nadkarni KM. Indian Materia Medica, Popular Prakashan, Pvt. Ltd. Mumbai, Edn 3rd. 1999;1:1019 1021.

20. Rafeequddin M, Kanz-ul-Advia Mufrada. First Edition, published by university publication unit, Sarfaraz House, AMU, Aligarh, 1985, 131-132.

21. Rastogi RP, Mehra BN. Compendium of Indian medicinal plants, Central Drug Research institute, Lucknow, publications and information directorate, New Delhi,1991; 1:322

22. Abdul Hakeem HM. Bustanul Mufradat Jadeed. New Delhi.: Idara Kitab al Shifa; 2002. 109, 509–10, 598, 428–29p

23. Khan MS, Lari QH, et al. Babchi (Psoralea corylifolia Linn.) and it’s therapeutic uses in Unani system of medicine, International Journal of Pharmaceutical and Phytopharmacological Research. 2015;5(1):41-45.

24. Kirtikar KR, Basu BD. Indian medicinal plant, International Book Distributors, Edn, 2nd. 1975;4:2581- 2583.

25. Rafeequddin M, Kanz-ul-Advia Mufrada. First Edition, published by university publication unit, Sarfaraz House, AMU, Aligarh, 1985, 131-132

26. Hakīm K. Al-Qarābādīn. Tabaʻ Sāni. New Delhi: Central Council For Research in Unani Medicine; 2006. 222p.

27. Khan Shareef Hk. Ilaj-ul-amraz 2nd edition (Urdu translation by CCRUM). New Delhi: Ministry of Health and Family Welfare: published 2005 p 816

28. Najmul Ghani Khan. (2010). Qarabadeen Najmul Ghani. New Delhi: Central Council for Research in Unani Medicine (CCRUM), Ministry of AYUSH, Government of India.

29. Mukherjee PK. Business Horizons Quality Control of Herbal Drugs: An Approach to Evaluation of Botanicals, New Delhi, 2002, 761-3.

30. Maisch JM. Useful plants of the genus Psoralea. The American Journal of Pharmacy. 1889;61(7).

31. Kokate C.K., Purohit A.P., Gokhale S.B., Pharmacognosy, 49th Edition, Nirali Prakashan.

32. Trease and Evans Pharmacognosy, 16th Edition, Saunders Elsevier.

33. Wealth of India: A Dictionary of Indian Raw Materials and Industrial Products, Vol. VIII (Ph–Re), CSIR, New Delhi.

34. Sharma P, Yelne M, Dennis T, Joshi A, Billore K. Database on medicinal plants used in Ayurveda, 2000.

35. Chopra RN, et al. Indigenous Drug of India, Edition, UN Dhur, and Sons Pvt. Ltd., Calcutta. 1958;3rd:391 392

36. Alam F, Khan GN, Asad Bin. Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: A review [Internet]. Vol. 32, Phytotherapy Research. 2018. p. 597–615. Available from: https://www.researchgate.net/publication/321855975

37. Kim KA, Shim SH, Ahn HR, Jung SH. Protective effects of the compounds isolated from the seed of Psoralea corylifolia on oxidative stress‐induced retinal damage. Toxicology and Applied Pharmacology. 2013;269(2):109-120. https://doi.org/10.1016/j.taap.2013.03.017

38. Buyukbalci A, Sedef Nehir EI. Determination of in vitro antidiabetic effects, antioxidant activities and phenol contents of some herbal teas, Plants Food Hum Nutr. 2008;63(1):27- 33. https://doi.org/10.1007/s11130-007-0065-5

39. Forestieri AM, Monfortre MT, Ragusa S, Trovato A, Lauk L. Anti-inflammatory, Analgesic and antipyretic activity in rodents of plant extract used in African medicine phytother Res. 1996; 10(2):100-103. https://doi.org/10.1002/(SICI)1099-1573(199603)10:2%3C100::AID-PTR724%3E3.0.CO;2-I

40. Chen CH, Hwang TL, Chen LC, Tsung-Hsien Chang TH, Wei CH, Chen JJ. Isoflavones and antiinflammatory constituents from the fruits of Psoralea corylifolia, Phytochemistry, 2017; 143:186-193. https://doi.org/10.1016/j.phytochem.2017.08.004

41. Kim DW, Seo KH, Curtis‐Long MJ, Oh KY, Oh JW, Cho JK, et al. Phenolic phytochemical displaying SARS‐CoV papain‐like protease inhibition from the seeds of Psoralea corylifolia. Journal of Enzyme Inhibition and Medicinal Chemistry. 2014;29(1):59-63. https://doi.org/10.3109/14756366.2012.753591

42. Aslan M, Orhan N, Orhan DD, Ergun F. Hypoglycemic activity and antioxidant potential of some medicinal plants traditionally used in Turkey for diabetes, J Ethnopharmacol. 2010;128(2):384-389. https://doi.org/10.1016/j.jep.2010.01.040

43. Iwamura J, Dohi T, Tanaka H, Odani T, Kubo M. Cytotoxicity of Corylifolia fructus. II. Cytotoxicity of bakuchiol and the analogues. Yakugaku zasshi: Journal of the Pharmaceutical 1989;109(12):962-965. Society of Japan. https://doi.org/10.1248/yakushi1947.109.12_962

44. Gidwani, beena, alaspure, RN, duragkar, NJ, singh, vijay, RAO, S.prakash, & shukla, S.S.. (2010). Evaluation of a novel herbal formulation in the treatment of eczema with psoralea corylifolia. Iranian journal of dermatology, 13(4 (54)), 122-127. Sid. https://sid.ir/paper/579609/en

45. Wang, Y.; Hong, C.; Zhou, C.; Xu, D.; Qu, H.B. Screening anti-tumour compounds psoralen and isopsoralen from Psoralea corylifolia L. Seeds. Evidence-Based Compl. Alt. Med., 2011, 363052. https://doi.org/10.1093/ecam/nen087

46. Chen, Z.; Jin, K.; Gao, L.; Lou, G.; Jin, Y.; Yu, Y.; Lou, Y. Anti-tumor effects of bakuchiol, an analogue of resveratrol, on human lung adenocarcinoma A549 cell line. Eur. J. Pharmacol., 2010, 643(2-3), 170-179. https://doi.org/10.1016/j.ejphar.2010.06.025

47. Yang, Y.; Paik, J. H.; Cho, D.; Cho, J.A.; Kim, C.W. Resveratrol induces the suppression of tumor-derived CD4+CD25+ regulatory T cells. Int. Immunopharmacol., 2008, 8(4), 542-547. https://doi.org/10.1016/j.intimp.2007.12.006

48. Wang TX, Yin ZH, Zhang W, Peng T, Kang WY. Chemical constituents from Psoralea corylifolia and their antioxidant alpha‐glucosidase inhibitory and antimicrobial activities, Zhongguo Zhong Yao Za Zhi. 2013a;38(14):2328-2333. https://europepmc.org/search?query=JOURNAL%3A%22Zhongguo%20Zhong%20Yao%20Za%20Zhi%22

49. Hosamani P, Lakshman H, Sandeepkumar K. Antimicrobial activity of leaf extract of Psoralea corylifolia L. Life Science Leaflets, 2012. http://lifesciencesleaflets.ning.com/

50. Limper C, Wang Y, Ruhl S, Wang Z, Lou Y, Totzke F, et al. Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells. Journal of Pharmacy and Pharmacology. 2013;65(9):1393-1408. https://doi.org/10.1111/jphp.12107

51. Cho H, Jun JY, Song EK, Kang KH, Baek HY, Ko YS, Kim YC. “Bakuchiol: A hepatoprotective compound of Psoralea corylifolia on tacrine – induced cytotoxicity in Hep G2 cells” Planta Med. 2001; 67(08):750-751. https://doi.org/10.1055/s-2001-18347

52. Ghosh D, Bera T, Chatterjee K, Ali K, Debasis D. Antidiabetic and antioxidative effects of aqueous extract of seed of Psoralea corylifolia (somraji) and seed of Trigonella foenum‐graecum L., (methi) in separate and composite manner in streptozotocin‐induced diabetic male albino rat. Intl J Pharm Res Dev. 2009;7(9):1-10.

53. Ling F, Lu C, Tu X, Yi Y, Huang A, Zhang Q, et al. Antiprotozoal screening of traditional medicinal plants: Evaluation of crude extract of Psoralea corylifolia against Ichthyophthirius multifiliis in goldfish, Parasitology Research. 2013;112(6):2331-2340. https://doi.org/10.1007/s00436-013-3397-0

54. Latha PG, Evans DA, Panikkar KR. Jayavardhanan KK. Immunomodulatory and antitumour properties of Psoralea corylifolia seeds. Fitoterapia. 2000;71(3):223 231. https://doi.org/10.1016/S0367-326X(99)00151-3

55. Khare CP. Indian Medicinal Plants An Illustrated Dictionary. 1st ed. New York: Springer Science + Business Media; 2007. 5–6, 75–76, 266–67, 523, 733–34 p.

Published

2025-08-15
Statistics
Abstract Display: 627
PDF Downloads: 483
PDF Downloads: 124

How to Cite

1.
Abdullah D, Khan Y, Shaida L, Kabeer A, Taha MN. Psoralea corylifolia L. (Babchi): A Comprehensive Review of Its Phytochemistry, Pharmacology and Ethnomedicinal Applications in the AYUSH (Unani) System of Medicine. J. Drug Delivery Ther. [Internet]. 2025 Aug. 15 [cited 2026 Jan. 23];15(8):259-66. Available from: https://jddtonline.info/index.php/jddt/article/view/7318

How to Cite

1.
Abdullah D, Khan Y, Shaida L, Kabeer A, Taha MN. Psoralea corylifolia L. (Babchi): A Comprehensive Review of Its Phytochemistry, Pharmacology and Ethnomedicinal Applications in the AYUSH (Unani) System of Medicine. J. Drug Delivery Ther. [Internet]. 2025 Aug. 15 [cited 2026 Jan. 23];15(8):259-66. Available from: https://jddtonline.info/index.php/jddt/article/view/7318

Most read articles by the same author(s)