IN VITRO ANTICANCER EFFECT OF ARTABOTRYS CRASSIFOLIUS HOOK.F. & THOMSON AGAINST HUMAN CARCINOMA CELL LINES

  • Kok Kwan Tan School of Pharmacy, Faculty of Science, The University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia.
  • Tracey D Bradshaw Centre for Biomolecular Sciences, School of Pharmacy, The University of Nottingham, University Park, Nottingham NG7 2RD, UK.
  • Jessica Chu Centre for Biomolecular Sciences, School of Pharmacy, The University of Nottingham, University Park, Nottingham NG7 2RD, UK.
  • Teng Jin Khoo School of Pharmacy, Faculty of Science, The University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia.
  • Christophe Wiart School of Pharmacy, Faculty of Science, The University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia.

Abstract

The aim of the present study was to investigate the anticancer effects of crude extracts of Artabotrys crassifolius on the growth of human breast and colorectal carcinoma cell lines. The leaves and barks of Artabotrys crassifolius were extracted sequentially with hexane, chloroform and ethanol. The corresponding crude extracts obtained were then tested for their anticancer activity using MTT assay. Among the extracts studied, chloroform and hexane extracts of barks were found to possess the most potent anticancer activity which necessitates further isolation and characterisation of the bioactive compounds present in the respective extracts.

Keywords: Anticancer, Artabotrys crassifolius, Human carcinoma cell lines

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Tan K, Bradshaw T, Chu J, Khoo T, Wiart C. IN VITRO ANTICANCER EFFECT OF ARTABOTRYS CRASSIFOLIUS HOOK.F. & THOMSON AGAINST HUMAN CARCINOMA CELL LINES. JDDT [Internet]. 8Jan.2014 [cited 29Jul.2021];4(1):1-. Available from: https://jddtonline.info/index.php/jddt/article/view/728