The Comprehensive Review of the Preventive facet of Fatty Liver Disease under the Paradigm of Unani Medicine

Authors

  • Saleha Hasan https://orcid.org/0009-0004-3729-1830
  • Ammar-Ibne-Anwar Assistant professor, Dept. of Tahaffuzi wa Samaji Tib, Ajmal Khan Tibbiya College
  • Samreen Farha PG Scholar, Dept. of Ilaj-bit-Tadbeer, Faculty of Unani Medicine, AMU, Aligarh, India

Abstract

The liver, recognized as the largest and most vital organ, plays a central role in maintaining the body’s Hararat-e-Ghariziya (innate heat) according to the Unani system of medicine, which has a rich tradition in diagnosing and treating liver disorders. Fatty Liver Disease (FLD), or hepatic steatosis, is a reversible condition characterized by the abnormal accumulation of triglycerides within liver cells, resulting from various causes such as excessive alcohol consumption, obesity, insulin resistance, and metabolic dysfunction. Both alcoholic and non-alcoholic forms of FLD share similar histopathological features, including micro- and macrovesicular fatty changes, making clinical distinction challenging. Unani medicine attributes such liver imbalances to a disruption in the body’s natural temperament and heat regulation, emphasizing prevention through lifestyle modifications, dietary management, and the use of hepatoprotective herbs. This review provides an integrative perspective on FLD, combining modern medical understanding with classical Unani principles to highlight effective preventive and therapeutic strategies rooted in traditional medicine.

Keywords: Fatty Liver Disease, Hararat-e-Ghariziya, Unani Medicine, Insulin Resistance, Hepatic Steatosis, Preventive Care

Keywords:

Fatty Liver Disease, Hararat-e-Ghariziya, Unani Medicine, Insulin Resistance, Hepatic Steatosis, Preventive Care

DOI

https://doi.org/10.22270/jddt.v15i7.7263

Author Biographies

Saleha Hasan

PG Scholars, Dept. of Tahaffuzi wa Samaji Tib, Ajmal Khan Tibbiya College

Ammar-Ibne-Anwar , Assistant professor, Dept. of Tahaffuzi wa Samaji Tib, Ajmal Khan Tibbiya College

Assistant professor, Dept. of Tahaffuzi wa Samaji Tib, Ajmal Khan Tibbiya College

Samreen Farha , PG Scholar, Dept. of Ilaj-bit-Tadbeer, Faculty of Unani Medicine, AMU, Aligarh, India

PG Scholar, Dept. of Ilaj-bit-Tadbeer, Faculty of Unani Medicine, AMU, Aligarh, India

References

1. Reddy JK, Rao MS. Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. Am J Physiol Gastrointest Liver Physiol, 2006; 290(5): G852–G858.

2. Tabri R. Firdaus-ul-Hikmat (Urdu), Vol. 1 & 2. Lahore: Sheikh Mohammad Bashir & Sons; 1997. p. 206–210.

3. Cleveland E, Bandy A, VanWagner LB. Diagnostic challenges of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Clin Liver Dis (Hoboken), 2018; 11(4): 98–104.

4. Misra A, Soares MJ, Mohan V, Anoop S, Abhishek V, Vaidya R, Pradeepa R. Body fat, metabolic syndrome and hyperglycemia in South Asians. J Diabetes Complications, 2018; 32(11): 1068–1075.

5. National Center for Biotechnology Information. StatPearls – Fatty Liver Disease [Internet]. 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441992

6. Marchesini G, Bugianesi E, Forlani G, Cerrelli F, Lenzi M, Manini R, Natale S, Vanni E, Villanova N, Melchionda N, Rizzetto M. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology, 2003; 37(4): 917–923. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC2674744/

7. NY Post. Lack of sleep linked to fatty liver risk, study finds. 2024. Available from: https://nypost.com/2024/04/17/health/lack

8. Wikipedia. Fatty liver disease. Available from: https://en.wikipedia.org/wiki/Fatty_liver_disease

9. Nasiri-Ansari N, et al. Therapeutic potential of herbal medicine in NAFLD. Front Pharmacol, 2020; 11: 603926. Available from: https://www.frontiersin.org/articles/10.3389/fphar.2020.603926/full

10. Mayo Clinic. Nonalcoholic fatty liver disease – Symptoms and causes. Available from: https://www.mayoclinic.org/diseases-conditions/nonalcoholic-fatty-liver-disease/symptoms-causes/syc-20354567

11. Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease: Meta‐analytic assessment of prevalence, incidence, and outcomes. Hepatology, 2016; 64(1): 73–84.

12. Younossi ZM, et al. Global burden of NAFLD and NASH: Trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol, 2018; 15(1): 11–20. https://doi.org/10.1038/nrgastro.2017.109

13. Chalasani N, et al. The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the AASLD. Hepatology, 2018; 67(1): 328–357. https://doi.org/10.1002/hep.29367

14. Anderson EL, Howe LD, Jones HE, Higgins JPT, Lawlor DA, Fraser A. Prevalence of NAFLD in children and adolescents: A systematic review and meta-analysis. Pediatrics, 2015; 135(1): e138–e147. https://doi.org/10.1542/peds.2014-0617

15. Ibn Sina. Al-Qanun fi al-Tibb, Vol. 2: On Liver Diseases.

16. Jurjani. Zakhira Khwarizm Shahi, Vol. 3: Liver and Humor Derangement.

17. Zakariya Razi. Kitab al-Hawi: Describes hepatic conditions and metabolic disturbances.

18. Parveen H, Siddiqui MY. Fatty liver disease: A holistic concept. Health Journal of Unani Medicine (HJUM), 2022; 7(3): 20–28. Available from: https://journals.lww.com/hjum/fulltext/2022/07000/fatty_liver_disease__a_holistic_concept

19. Naqvi H. Unani understanding of NAFLD: An integrative perspective. J Complement Integr Med, 2021; 18(4): 867–874. https://www.degruyterbrill.com/document/doi/10.1515/jcim-2021-0296

20. Siddiqui MA. Concept and management of fatty liver disease in Unani medicine vis-a-vis conventional medicine. Available from: https://www.researchgate.net/publication/378342168

21. Razi Z. Kitab Al Hawi, Vol. 7. New Delhi: CCRUM; 2000. p. 47–85. Ibn Zuhr AM. Kitabut Taiseer. New Delhi: CCRUM; 1986. p. 114.

22. Ibn Sina. Al-Qanoon fit-Tib (Urdu Translation by Ghulam Hussain Kantoori), Vol. 3. New Delhi: Idara Kitabul Shifa; 2010. p. 854–864.

23. CCRUM. Unani Mufradat (Single Drugs) In Nutshell, Part I.

24. Unani Pharmacopoeia. Murakkabat (Unani Formulations). Vol. 2. Available from: https://ia600807.us.archive.org/32/items/murakkabatunaniformulation2/murakkabat%20%28unani%20formulation%29-2.pdf

Published

2025-07-15
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How to Cite

1.
Hasan S, Anwar A-I, Farha S. The Comprehensive Review of the Preventive facet of Fatty Liver Disease under the Paradigm of Unani Medicine. J. Drug Delivery Ther. [Internet]. 2025 Jul. 15 [cited 2026 Jun. 14];15(7):225-32. Available from: https://jddtonline.info/index.php/jddt/article/view/7263

How to Cite

1.
Hasan S, Anwar A-I, Farha S. The Comprehensive Review of the Preventive facet of Fatty Liver Disease under the Paradigm of Unani Medicine. J. Drug Delivery Ther. [Internet]. 2025 Jul. 15 [cited 2026 Jun. 14];15(7):225-32. Available from: https://jddtonline.info/index.php/jddt/article/view/7263