Nobiletin as a Neuroprotective Agent: Therapeutic Potential and Formulation Strategies for Alzheimer’s and Related Disorders
Abstract
Objectives: The purpose of this review is to investigate the neuroprotective properties of the dietary polymethoxy flavone nobiletin (NOB), specifically in connection to Alzheimer's disease and other neurological conditions. To enhance the compound's medicinal effectiveness, it also examines its chemical properties, modes of action, and the latest developments in formulation techniques.
Data Sources: From 2000 to 2024, pertinent scientific literature on pharmacological investigations, formulation developments, and preclinical assessments of nobiletin was compiled from databases including PubMed, ScienceDirect, Google Scholar, and Web of Science.
Study selection: Research was chosen based on its experimental significance for the pharmacodynamics, bioavailability, neuroprotective effectiveness, and formulation technologies of nobiletin. Pharmacokinetic studies, patents, and in vitro and in vivo research were all included.
Summary of Contents: Citrus peels are the primary source of nobiletin, which has potent anti-inflammatory, antioxidant, anti-cancer, and neuroprotective qualities. Problems including low bioavailability and poor water solubility have prompted the creation of sophisticated formulations such as solid dispersions, micelles, and nanoemulsions. Its pharmacokinetic profile and therapeutic potential have been enhanced by these developments.
Conclusion: In conclusion, nobiletin has excellent potential as a neuroprotective agent, particularly for diseases such as Alzheimer's. Although its unique structure promotes metabolic stability and membrane permeability, problems with solubility and bioavailability are now limiting practical translation. Its future therapeutic usage depends on addressing these constraints with innovative formulation techniques.
Keywords: Citrus flavonoids, Alzheimer's disease, neuroprotection, nobiletin, bioavailability, and formulation techniques.
Keywords:
Nobiletin, Neuroprotection, Alzheimer’s disease, Citrus flavonoids, : Nano Structured Lipid Carrier, Bioavailability, Drug Delivery System, Nano Based Techniques.DOI
https://doi.org/10.22270/jddt.v15i7.7261References
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