Design, Formulation and In-Vitro Evaluation of Ketoconazole Microsponges by Quasi-Emulsion Solvent Diffusion Method
Abstract
Ketoconazole-loaded micro sponges were successfully formulated employing the quasi-emulsion solvent diffusion technique, aiming to optimize drug entrapment efficiency and enhance sustain release of the drug. Ethyl cellulose served as the release-retarding polymer, while polyvinyl alcohol (PVA) functioned as the emulsifying agent. Formulations were prepared in varying ratios of drug: PVA: ethyl cellulose to assess the impact of composition on micro sponge properties. The effect of variables including the drug: polymer ratio, emulsifier (PVA) concentration in organic solvent (dichloro methane) was examined. FTIR studies confirmed that there was no significant changes in the characteristic peaks suggesting the absence of interactions between the ketoconazole and the polymer. The encapsulation efficiency for selected (F4) formulation was found to be 94.78%. SEM analysis determined the surface morphology of microsponges and particle size of the microsponges were within the limits. The maximum in-vitro percentage drug release for F4 formulation was found to be 92.87% over 12h. These results indicate that ketoconazole-loaded microsponges, formulated with ethyl cellulose and PVA, are a promising system for sustained antifungal drug delivery.
Keywords: Ethyl cellulose, poly vinyl alcohol, FTIR, SEM, micro sponges, drug release studies.
Keywords:
Ethyl cellulose, poly vinyl alcohol, FTIR, SEM, micro sponges, drug release studiesDOI
https://doi.org/10.22270/jddt.v15i7.7244References
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