Pharmacotherapy for Severe Malaria in Children Under Five Years Old in the Pediatric Department Gabriel TOURE Teaching Hospital Bamako
Abstract
Introduction: Despite efforts to reduce the malaria burden, the disease remains a public health problem in Mali. The aim of this study was to analyse compliance with drug management for severe malaria in children under 5 years old.
Methodology: A retrospective cross-sectional descriptive study was carried out using data from June to December 2021 from the in the pediatric department Gabriel TOURE teaching hospital Bamako.
Results: During the six months period of the study, 238 patients were included. More than half of the children (55.5%) with severe malaria were male, with a sex ratio of 1.24. The main reasons for referral were anaemia (65.13%), followed by seizures (33.61%) and fever (26.47%). All patients with severe malaria were confirmed by paraclinical investigations. In accordance with NMCP guidelines, all patients with severe malaria were treated with artesunate. A total of 58.82% of patients received the combination of artemether and lumefantrine tablets. Regarding non-antimalarial drugs, paracetamol IV and ceftriaxone IV were the most widely administered drugs. Noncompliance concerns the lack of relay treatment with an oral artemisinin-based combination and antibiotic therapy based on the results of the blood count.
Conclusion: The nonconformities identified show the urgent need to focus on discharge prescribing oral artemisinin-based combination at discharge and the appropriate use of antibiotics.
Keywords: severe malaria, children, artesunate, compliance, Mali.
Keywords:
severe malaria, children, artesunate, compliance, MaliDOI
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