The Role of Ferula asafoetida in Neurological, Antidiabetic and Gastrointestinal Therapies: Unani Perspective

Authors

  • Bushra Fasiha A.R. Shaikh Research scholar, National institute of Unani medicine Bengaluru, India
  • Khadija Abdul Hafeez Research officer, CCRUM, New Delhi, India
  • Ghulammudin Sofi Prof. Dept. of Ilmul Advia, National institute of unani medicine Bengaluru, India
  • Shariq-ur-rahim Shaikh Proprietor Hikmat Clinic Nagpur, India
  • Momin Shahezad Aamir Associate prof. Dept. of Tashreehul Badan, Mohammadia Tibbia college Malegaon, Maharashtra, India

Abstract

Objective: To provide a comprehensive overview of Hilteet, including its traditional uses, botanical characteristics, chemical composition, pharmacological activities, and potential areas for future research.

Data sources: A review of literature on Ferula asafoetida was done based on bibliographic database viz. Science Direct, Scopus, Pub Med, and Google Scholar. Important informative data were also collected from classical and conventional textbooks, journals and resale.

Background: Ferula asafoetida Regal (Hilteet) is an oleo-gum-resin obtained from the rhizomes and roots of Ferula asafoetida Regel Syn., Ferula narthex Boiss, and other species of Ferula from the Umbelliferae family. It has a long history of medicinal use, first documented by Theophrastus and Dioscorides, and is frequently employed in Unani medicine. Traditionally widely used in Unani medicine for various ailments. Razi recommended its application in paralysis and developed "Majoon-e-Hilteet," which has been demonstrated as a nervine stimulant. Botanically it belongs to Umbelliferae family, Derived from specific species of the Ferula genus. Chemically it is composed of some bioactive compounds responsible for its medicinal properties. Pharmacologically it Exhibits nervine stimulant effects and other therapeutic activities, as supported by existing literature.

Conclusion and Future Directions: The review highlights the traditional significance and pharmacological potential of Hilteet while identifying opportunities for further research to advance herbal medicine.

Keywords: Ferula Asafoetida; ethnopharmacology; gastrointestinal; neurological; traditional medicine 

Keywords:

Ferula Asafoetida, ethnopharmacology, gastrointestinal, neurological, traditional medicine

DOI

https://doi.org/10.22270/jddt.v15i4.7111

Author Biographies

Bushra Fasiha A.R. Shaikh, Research scholar, National institute of Unani medicine Bengaluru, India

Research scholar, National institute of Unani medicine Bengaluru, India

Khadija Abdul Hafeez , Research officer, CCRUM, New Delhi, India

Research officer, CCRUM, New Delhi, India

Ghulammudin Sofi , Prof. Dept. of Ilmul Advia, National institute of unani medicine Bengaluru, India

Prof. Dept. of Ilmul Advia, National institute of unani medicine Bengaluru, India

Shariq-ur-rahim Shaikh, Proprietor Hikmat Clinic Nagpur, India

Proprietor Hikmat Clinic Nagpur, India

Momin Shahezad Aamir , Associate prof. Dept. of Tashreehul Badan, Mohammadia Tibbia college Malegaon, Maharashtra, India

Associate prof. Dept. of Tashreehul Badan, Mohammadia Tibbia college Malegaon, Maharashtra, India

References

1. Mahboubi M. The beneficial effects of Ferula asafoetida oleo-gum resin in The beneficial effects of Ferula asafoetida oleo-gum resin in gastrointestinal disorders gastrointestinal disorders. 2022 [cited 2025 Apr 8];59. Available from: https://doi.org/10.54634/2090-9101.1025

2. Mala KN, Thomas J, Syam DS, Maliakel B, Krishnakumar IM. Safety and Efficacy of Ferula asafoetida in Functional Dyspepsia: A Randomized, Double-Blinded, Placebo-Controlled Study. Evid Based Complement Alternat Med [Internet]. 2018 [cited 2025 Apr 8];2018. Available from: https://pubmed.ncbi.nlm.nih.gov/30224930/

3. Moghadam FH, Vakili Zarch B, Shafiei M. Double edged effect of gum-resin of ferula assa-foetida on lifespan of neurons. Iran J Basic Med Sci [Internet]. 2013 [cited 2025 Apr 8];16(4):660. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC3821887/

4. Bagheri SM, Maghsoudi MJ, Yadegari M. Preventive Effect of Ferula asafoetida Oleo Gum Resin on Histopathology in Cuprizone-Induced Demyelination Mice. Int J Prev Med [Internet]. 2020 [cited 2025 Apr 8];11(1):179. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7804879/

5. Javaid R, Javed G, Javaid R, Anju , Ahmed F, Khan AA. HING (Ferula foetida Regel): A potent Unani Herb with its descriptive parameters of pharmacognosy and pharmacology: A Review. Journal of Drug Delivery and Therapeutics [Internet]. 2020 Sep 15 [cited 2025 Apr 8];10(5):362–7. Available from: https://jddtonline.info/index.php/jddt/article/view/4372

6. Ali HSS. Unani Avia Mufarrada. New Delhi: Qoumi council baraye farogh urdu zaban; 1979. 32–33 p.

7. Anonymous. The Unani Pharmacopeia of India. Part I. vol.I. New Delhi: Dept. of AYUSH Ministry of H&FW govt. of India; 2007. 36–37 p.

8. Kokate CK, Purohit AP GSB. Pharmacognocy.52nd edition. Pune: Nirali Prakashan; 2016. 14,112.

9. William Dymock, C.J.H.Wardnen DH. Pharmacographia India-A History of Principle Drugs of vegitable Origin.vol.II. New Delhi: Srishthi Book Distributors; 2005. 147–156 p.

10. Anonymous. Standardisation of Single Drugs of Unani Medicine. part I. New Delhi: CCRUM; 1987. 104–08 p.

11. Rafiquddin M. kanzul Advia Mufredah. Aligarh: Muslim University Aligarh; 1985. 90-91,307-309 p.

12. Ghani H N. Khazain-Ul-Advia.ed.3rd. New Delhi: Idara Kitabushifa; 2011. 1084-86,43-44 p.

13. Indian medicinal plants Vol_3 : Kirtikar, K.R.; Basu, B.D. : Free Download, Borrow, and Streaming : Internet Archive [Internet]. [cited 2019 Mar 26]. Available from: https://archive.org/details/in.gov.ignca.2048/page/n5

14. K.R.Kirtiker,B.D Basu. Indian Medicinal Plants.vol.IInd . Dehradun, Uttaranchal, India: International book distributers; 2006. 1216–18 p.

15. Baitar I. Al-Jame-li-Mufredat Al-Advia-Wal-Aghziya (Urdu translation by CCRUM). Vol.IInd. New Delhi: CCRUM; 2000. 58–60 p.

16. Kirtiker K.R. BBD. Indian Medicinal Plants. Vol. III. 2nd ed. Dehradun India: International book distributers; 2008. 1972–74 p.

17. Natural Resources Conservation Service. Classification | USDA PLANTS [Internet]. 2018 [cited 2019 Mar 29]. p. 2018. Available from: https://plants.usda.gov/java/ClassificationServlet?source=display&classid=LAST9

18. Anonymous. The Wealth of India: A Dictionary of Indian Raw Materials and Industrial Products. Vol. 8, Publication and Information Directorate, CSIR, New Delhi. New Delhi: CSIR; 1998. 120 p.

19. Ibrahim ASB. Kitab Al-Fatah fi al Tadawi (Urdu translation by Hakim Abdul Bari). New Delhi: Dept. of AYUSH Ministry of H&FW govt. of India; 2007. 46–47, 112–113 p.

20. Nadkeri KM. Indian Materia medica. Mumbai: papular prakashan private limited; 1982. 537–41 p.

21. Bonhage-Freund MT. Handbook of Medicinal Plants. 4th ed. Vol. 60, Economic Botany. Jaipur: Pointer publishers; 2006.

22. ICD-10 Diagnosis Code G20 Parkinson’s disease [Internet]. Available from: http://icdlist.com/icd-10/clinical-concepts/ - Google Search [Internet]. [cited 2025 Feb 18]. Available from: https://www.google.com/search?q=ICD-10+Diagnosis+Code+G20+Parkinson%E2%80%99s+disease+%5BInternet%5D.+Available+from%3A+http%3A%2F%2Ficdlist.com%2Ficd-10%2Fclinical-concepts%2F&rlz=1C1CHBF_enIN1131IN1131&oq=ICD-10+Diagnosis+Code+G20+Parkinson%E2%80%99s+disease+%5BInternet%5D.+Available+from%3A+http%3A%2F%2Ficdlist.com%2Ficd-10%2Fclinical-concepts%2F&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIHCAEQIRiPAjIHCAIQIRiPAtIBCDE4MDVqMGo3qAIIsAIB&sourceid=chrome&ie=UTF-8

23. khan M A. Muheet Azam (Urdu translation by CCRUM). Vol.IInd. New Delhi: CCRUM; 2013. 369–72 p.

24. Amalraj A, Gopi S. Biological activities and medicinal properties of Asafoetida: A review. J Tradit Complement Med [Internet]. 2017;7(3):347–59. Available from: http://dx.doi.org/10.1016/j.jtcme.2016.11.004

25. Allan H. Ropper MAS. The neurology of aging. In: principles of neurology. USA: McGraw-Hill Companies; 2009. p. 580–7.

26. Haleem HMA. Mufredate Azizi. New Delhi: CCRUM; 2009. 13,49.

27. Bhattacharjee S K. Handbook of Medicinal Plants. Ed.4th. Jaipur India: Pointer publishers; 2004. 202–3 p.

28. Fatehi M, Farifteh F, Fatehi-Hassanabad Z. Antispasmodic and hypotensive effects of Ferula asafoetida gum extract. J Ethnopharmacol [Internet]. 2004 Apr 1 [cited 2019 Apr 15];91(2–3):321–4. Available from: https://www.sciencedirect.com/science/article/pii/S0378874104000285

29. Kavoosi G, Rowshan V. Chemical composition, antioxidant and antimicrobial activities of essential oil obtained from Ferula assa-foetida oleo-gum-resin: Effect of collection time. Food Chem [Internet]. 2013 Jun 15 [cited 2019 Apr 15];138(4):2180–7. Available from: https://www.sciencedirect.com/science/article/pii/S0308814612019048

30. Bhatnager R, Rani R, Dang AS. Antibacterial activity of Ferula asafoetida: a comparison of red and white type. J Appl Biol Biotechnol. 2015;3(02):18–21.

31. Shrivastava V, Bhardwaj U, Sharma V, Mahajan N, Sharma V, Shrivastava G. Antimicrobial activities of Asafoetida resin extracts (a potential Indian spice). J Pharm Res [Internet]. 2012 [cited 2019 Apr 16];5(10):5022–4. Available from: https://www.researchgate.net/profile/Vikas_Shrivastava4/publication/276271274_Antimicrobial_activities_of_Asafoetida_resin_extracts_A_Potential_Indian_Spice/links/55a7360208ae51639c576a75/Antimicrobial-activities-of-Asafoetida-resin-extracts-A-Potential-I

32. Mahendra P, Bisht S. Ferula asafoetida: Traditional uses and pharmacological activity. Pharmacogn Rev [Internet]. 2012 Jul [cited 2019 Apr 18];6(12):141–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23055640

33. Kamble VA, Patil SD. Spice-Derived Essential Oils: Effective Antifungal and Possible Therapeutic Agents. J Herbs Spices Med Plants [Internet]. 2008 Dec 15 [cited 2019 Apr 17];14(3–4):129–43. Available from: http://www.tandfonline.com/doi/abs/10.1080/10496470802598677

34. Saleem M, Alam A, Sultana S. Asafoetida inhibits early events of carcinogenesis. Life Sci [Internet]. 2001 Mar [cited 2019 Apr 18];68(16):1913–21. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0024320501009778

35. Sciences AAZPJ of B, 2010 undefined. Anti-diabetic activity of Ferula assafoetida extract in normal and alloxan-induced diabetic rats. docsdrive.com [Internet]. [cited 2019 Apr 18]; Available from: http://docsdrive.com/pdfs/ansinet/pjbs/2010/97-100.pdf

36. Hejazian S, Dashti-R M, Bagheri S. The Relaxant Effect of Seed′s Essential Oil and Oleo-gum-resin of Ferula Assa-foetida on Isolated Rat′s Ileum. Ann Med Health Sci Res [Internet]. 2014 [cited 2019 Apr 18];4(2):238. Available from: https://www.ajol.info/index.php/amhsr/article/view/112233

37. Khazdair MR, Boskabady MH. The relaxant effect of Ferula assafoetida on smooth muscles and the possible mechanisms. Journal of HerbMed Pharmacology [Internet]. 2015 [cited 2019 Apr 18];4(2):40–4. Available from: http://eprints.skums.ac.ir/4748/

38. Tayeboon GS, Tavakoli F, Hassani S, Khanavi M, Sabzevari O, Ostad SN. Effects of Cymbopogon citratus and Ferula assa-foetida extracts on glutamate-induced neurotoxicity. In Vitro Cell Dev Biol Anim [Internet]. 2013 [cited 2019 Apr 18];49(9):706–15. Available from: https://www.researchgate.net/publication/255958646

39. Moghaddam M, Farhadi N. Influence of environmental and genetic factors on resin yield, essential oil content and chemical composition of Ferula assa-foetida L. populations. J Appl Res Med Aromat Plants [Internet]. 2015 [cited 2019 Apr 18];2(3):69–76. Available from: https://www.sciencedirect.com/science/article/pii/S2214786115000169

40. Natural Resources Conservation Service. Classification | USDA PLANTS [Internet]. 2018 [cited 2019 Apr 4]. p. 2018. Available from: https://plants.usda.gov/java/ClassificationServlet?source=display&classid=FEAS2

41. Duke JA. Hand Book of Medicinal Herbs. LLC: CRC press; 2006.

42. Akhlaghi H. Volatile Constituents from the Aerial Parts of Ferulago angulata (Schlecht.) Boiss. Growing Wild Northeast Iran. Analytical Chemistry Letters [Internet]. 2012 [cited 2025 Apr 14];2(2):133–8. Available from: https://www.tandfonline.com/doi/abs/10.1080/222979282000.10648261

43. Disorders GSJ of D& M, 2022 undefined. Insilico screening and pharmacokinetic properties of phytoconstituents from Ferula asafoetida H. Karst.(Heeng) as potential inhibitors of α-amylase and α-glucosidase. SpringerG SinghJournal of Diabetes & Metabolic Disorders, 2022•Springer [Internet]. [cited 2025 Apr 14]; Available from: https://link.springer.com/article/10.1007/s40200-022-01064-6

44. Erfani F, Farhadi F, … MINP, 2024 undefined. Evaluation of the Anti-diabetic Activity of Purified Compounds of Ferula assafoetida by in vitro and in silico Methods. journals.sagepub.comF Erfani, F Farhadi, M Iranshahi, M BoozariNatural Product Communications, 2024•journals.sagepub.com [Internet]. [cited 2025 Apr 14]; Available from: https://journals.sagepub.com/doi/abs/10.1177/1934578X241257125

45. Erfani F, Farhadi F, Iranshahi M, Boozari M. Evaluation of the Anti-diabetic Activity of Purified Compounds of Ferula assafoetida by in vitro and in silico Methods. Nat Prod Commun. 2024 Jun 1;19(6).

46. Javaid R, Javed G, … RJJ of D, 2020 undefined. HING (Ferula foetida Regel): A potent Unani Herb with its descriptive parameters of pharmacognosy and pharmacology: A Review. search.ebscohost.comR Javaid, G Javed, R Javaid, F Ahmed, AA KhanJournal of Drug Delivery & Therapeutics, 2020•search.ebscohost.com [Internet]. [cited 2025 Apr 14]; Available from: https://search.ebscohost.com/login.aspx?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=22501177&AN=145979004&h=LACyqEXjbTRMLjHdfogmq1cbr4jVUWaDo9N%2FtQZXhFlYtogBF23m0dXU%2Bd3d%2FlMmY7BhZLMGQCOFwLlIUopXbQ%3D%3D&crl=c

47. Ministry of Health & Family Welfare Government of India. NATIONAL FORMULARY OF UNANI MEDICINE. Vol. Part VI. New Delhi: CCRUM; 2011.

48. Sina I e. Alqanoon. (Urdu translation by Hakeem Ghulam Husnain Kantoori. vol.III. New Delhi: Idra-Kitab-Us-Shifa; 598–600 .

Published

15-04-2025
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How to Cite

1.
Shaikh BFA, Hafiz KA, Sofi G, Shaikh S- ur- rahim, Aamir MS. The Role of Ferula asafoetida in Neurological, Antidiabetic and Gastrointestinal Therapies: Unani Perspective. J. Drug Delivery Ther. [Internet]. 2025 Apr. 15 [cited 2025 Apr. 26];15(4):236-41. Available from: https://jddtonline.info/index.php/jddt/article/view/7111

How to Cite

1.
Shaikh BFA, Hafiz KA, Sofi G, Shaikh S- ur- rahim, Aamir MS. The Role of Ferula asafoetida in Neurological, Antidiabetic and Gastrointestinal Therapies: Unani Perspective. J. Drug Delivery Ther. [Internet]. 2025 Apr. 15 [cited 2025 Apr. 26];15(4):236-41. Available from: https://jddtonline.info/index.php/jddt/article/view/7111