Assessment and Comparison on Use of Non-Steroidal Anti-Inflammatory Drugs for the Management of Dysmenorrhea by Medical and Non-Medical Students
Abstract
Background: Primary dysmenorrhea is one of the most common gynecological problems among adolescent females. It is defined as painful menses in women with normal pelvic anatomy, usually beginning during adolescence. This study aims to assess the prevalence, management practices, and associated side effects of dysmenorrhea among these students, focusing particularly on the use of NSAIDs and self-medication. Method: A cross-sectional study was conducted from July 8, 2024, to August 4, 2024, at PUSHS, GPCAR, and PUCEF in Koshi Province, Sundarharaicha. The study included 186 undergraduate female students from medical and non-medical faculties at Purbanchal University who experienced dysmenorrhea. A self-administered, semi-structured questionnaire was used to gather data on demographic characteristics, menstrual history, and NSAID usage. Convenient sampling technique was used, and data analysis was performed using IBM SPSS version 27. Result: A total of 186 students (126 medical and 60 non-medical) were included in the study. 88.6% of students experienced dysmenorrhea, with similar prevalence rates in medical (88.1%) and non-medical students (89.6%). Among those affected, 60.8% used over-the-counter pain relievers, with a higher proportion of non-medical students (66.7%) relying on self-medication compared to medical students (57.9%). Mefenamic acid was the most preferred NSAID, used by 90.3% of NSAID users, but non-medical students showed a higher preference (95.0%) compared to medical students (87.7%). Although NSAIDs were generally reported as effective by 61.9% of users, medical students reported slightly higher effectiveness (64.4%) than non-medical students (57.5%). Side effects were reported by 75.22 % of NSAID users: Non-medical students experienced slightly fewer side effects (72.5%) compared to medical students (76.71%). Conclusion: Dysmenorrhea is highly prevalent among both medical and non-medical students, with NSAIDs being a common management method. Despite the efficacy of NSAIDs, significant side effects were reported, particularly among non-medical students. This underscores the need for better educational programs on safe NSAID use and alternative pain management strategies.
Keywords: Dysmenorrhea, NSAIDs, Menstrual Cycle, Self-medication, Side Effects, Medical Students, Non-medical Students
Keywords:
Dysmenorrhea, NSAIDs, Menstrual Cycle, Self-medication, Side Effects, Medical Students, Non-medical StudentsDOI
https://doi.org/10.22270/jddt.v15i4.7074References
1. Ezeukwu AO., Elochukwu P.U, Ojukwu C P, “Self-reported pain relief strategies for primary dysmenorrhea used by Nigerian female undergraduates” Int J Recent Sci Res, 2014; 5(1):261-5
2. Al-Asadi J, Qader R, “Dysmenorrhea and its impact on daily activities among secondary school students in Basra” Iraq. Fac Med Baghdad J, 2013; 55: 85–94. https://doi.org/10.32007/jfacmedbagdad.v4339-344%
3. Vlachou E, Owens DA, Lavdaniti M, Kalemikerakis J, Evagelou E, Margari N, et al. “Prevalence, Wellbeing, and Symptoms of Dysmenorrhea among University Nursing Students in Greece” Diseases, 2019;7 :5. https://doi.org/10.3390/diseases7010005.
4. Ferries-Rowe E, Corey E, Archer JS., “Primary Dysmenorrhea: Diagnosis and Therapy” Obstet Gynecol, 2020;136: 1047–58. https://doi.org/10.1097/AOG.0000000000004096
5. Dawood MY, “Current concepts in the etiology and treatment of primary dysmenorrhea” Acta Obstet Gynecol Scand Suppl, 1986;138: 7–10. https://doi.org/10.3109/00016348509157059
6. Aziato L, Dedey F, Clegg-Lamptey JNA, “The experience of dysmenorrhoea among Ghanaian senior high and university students: pain characteristics and effect” Reprod Health, 2014;11: 58. https://doi.org/10.1186/1742-4755-11-58
7. Potur DC, Bilgin NC, Komurcu N, “Prevalence of dysmenorrhea in university students in Turkey: effect on daily activities and evaluation of different pain management methods” Pain Manag Nurs, 2014;15: 768–77 https://doi.org/10.1016/j.pmn.2013.07.012
8. Kaur S, Sheoran P, Sarin J, “Assessment And Comparison of Dysmenorrhea in Terms of Severity of Pain and Utilization of Non Steroid Anti-Inflammatory Drugs among Unmarried and Married Women n.d”
9. Assefa N, Demissie A, Hailemeskel S, “Primary dysmenorrhea magnitude, associated risk factors, and its effect on academic performance: evidence from female university students in Ethiopia” IJWH, 2016;8: 489–96. https://doi.org/10.2147/IJWH.S112768
10. Farotimi AA, Esike J, Nwozichi CU, Ojediran TD, Ojewole FO. Knowledge, Attitude, and Healthcare-Seeking Behavior Towards Dysmenorrhea among Female Students of a Private University in Ogun State, Nigeria. Journal of Basic and Clinical Reproductive Sciences 2015;4 :33-8
11. Sunitha S, Dhanya D, Deepa Manohar, Shaiju S Daran, Vismaya Annie Vinod, Aleena Roy, “The self-medication practice in primary dysmenorrhea among pharmacy students-a cross-sectional questionnaire study” Int J Res Pharm Hos & Clin Pharm, 2019; 1:97–100. https://doi.org/10.33974/ijrhcp.v1i4.136
12. French L. Dysmenorrhea. Afp 2005;71:285–91.
13. Maia H, Maltez A, Studard E, Zausner B, Athayde C, Coutinho E, “Effect of the menstrual cycle and oral contraceptives on cyclooxygenase-2 expression in the endometrium” Gynecol Endocrinol, 2005;21: 57–61. https://doi.org/10.1080/09513590500099602
14. Chan WY, “Prostaglandins and nonsteroidal antiinflammatory drugs in dysmenorrhea” Annu Rev Pharmacol Toxicol, 1983;23: 131–49. https://doi.org/10.1146/annurev.pa.23.040183.001023.
15. Lundström V, Gréen K, “Endogenous levels of prostaglandin F2alpha and its main metabolites in plasma and endometrium of normal and dysmenorrheic women” Am J Obstet Gynecol, 1978; 130:640–6. https://doi.org/10.1016/0002-9378(78)90320-4
16. Grosser T, Smyth E, FitzGerald G, “Pharmacotherapy of Inflammation, Fever, Pain, and Gout. In: Brunton LL, Hilal-Dandan R, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 13th ed., New York, NY: McGraw-Hill Education; 2017
17. Vane JR, Botting RM, “Mechanism of Action of Anti-Inflammatory Drugs” Scandinavian Journal of Rheumatology, 1996;25: 9–21. https://doi.org/10.3109/03009749609097226
18. Nuha K, Rusmil K, Ganiem AR, Permadi W, Diah Herawati DM, “Single-Blind Randomized Controlled Trial: Comparative Efficacy of Dark Chocolate, Coconut Water, and Ibuprofen in Managing” Primary Dysmenorrhea. IJERPH 2023;20: 66-69. https://doi.org/10.3390/ijerph20166619
19. Feng X, Wang X, “Comparison of the efficacy and safety of non-steroidal anti-inflammatory drugs for patients with primary dysmenorrhea: A network meta-analysis: Mol Pain, 2018;14:1744806918770320. https://doi.org/10.1177/1744806918770320
20. Shrestha R, Bhandari MS, Shrestha SS, Shrestha JTM, Shrestha U, .” Self-medication in Primary Dysmenorrhea among Undergraduate Students in a Medical College: A Descriptive Cross-sectional Study” J Nepal Med Assoc, 2022;60: 1011–5. https://doi.org/10.31729/jnma.7816
21. Prabha Bharati J, Ulak S, Vaidya Shrestha M, Mani Dixit S, Acharya A, Bhattarai A, “Self-medication in Primary Dysmenorrhea among Medical and Nursing Undergraduate Students of a Tertiary Care Hospital: A Descriptive Cross-sectional Study” J Nepal Med Assoc, 2021;59. https://doi.org/10.31729/jnma.6397
22. Sugumar R, Krishniah V. “A prospective study of the pattern of drug use in primary dysmenorrhea in a tertiary care hospital, 2014
23. Parveen N, Majeed R, Zehra N, Rajar U, Munir A. Attitude and knowledge of medical students of Isra University about dysmenorrhoea and its treatment. Journal of Ayub Medical College, Abbottabad : JAMC 2009;21:159–62
Published



How to Cite
Issue
Section
Copyright (c) 2025 Nabin Thapa Magar , Sushil Regmi , Atul Adhikari , Bibek Dev , Jenish Timsina , Shashi Bhusan Das

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).