Formulation and Evaluation of Capsaicin Transemulgel for the Treatment of Arthritis
Abstract
Capsaicin (CAP)is a non-narcotic analgesic and anti-inflammatory drug used to relieve pain and inflammation associated with rheumatoid arthritis. Transemulgel is a new approach with combination emulsion and gel base having special characteristics dual controlled release for the treatment of various conditions arthritis. The present research work, a novel transemulgel with CAP (F1-F6) was formulated by using different concentration of gellan gum (GG) and xanthan gum (XG) as gelling agents with oil in water emulsion base. No significant drug-excipient interactions were observed in FT-IR studies. To evaluate various characterizations of transemulgel such as pH, spreadability, viscosity, gelation time, drug content, Invitro drug release of gel was examined in phosphate buffer pH-7.4 by Franz diffusion cell technique. The optimized transemulgel of (F5) showed pH of 5.8 ± 0.52 and viscosity of2840 ± 0.65cps. The percentage of drug content in the formulated transemulgel (F1-F6) was observed in the range of 84 to 96%w/w respectively. The optimal transemulgel spreadability was found to be 22.23 ± 0.25g·cm/s. The percentage of cumulative drug release from the formulations (F1-F3) were found to be in the range between 72.85 to 62.18% w/w and the batches (F4-F6) were observed in the range 76.85 to 70.66%w/w at the end of 6h.By considering all the investigated data while increase in concentration of GG and XG were influenced rheological properties, drug content efficiency, the Invitro drug release of transemulgel. The present investigate suggest that the CAP loaded transemulgel can be a promising topical delivery to relieve pain, inflammation and provided greater bioavailability to improve therapy.
Keywords: Topical delivery, Transemulgel, Capsaicin, Xanthan gum, Gellan gum, Emulsion, Arthritis
Keywords:
Topical delivery, Capsaicin, Xanthan gum, Gellan gum, Emulsion, ArthritisDOI
https://doi.org/10.22270/jddt.v15i1.6946References
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