The Invisible Threat: Microplastics in Human Blood and Placenta

Authors

  • Anjali Mishra Department of Pharmacy, Sarala Birla University, Mahilong, Ranchi, Jharkhand 835009 https://orcid.org/0000-0001-7676-7978
  • Sudipta Modak BCDA College of Pharmacy and Technology Campus-2, Madhyamgram, Kolkata, West Bengal, 700129
  • Shubhrojit Bhattacharjee Department of Pharmacy, Jharkhand Rai University, Namkum, Ranchi, Jharkhand 835009
  • Rupam Vishwanaath Department of Pharmacy, Jharkhand Rai University, Namkum, Ranchi, Jharkhand 835009
  • Anand Mohan Department of Pharmacy, Jharkhand Rai University, Namkum, Ranchi, Jharkhand 835009
  • Bipin Kumar Department of Pharmacy, Jharkhand Rai University, Namkum, Ranchi, Jharkhand 835009

Abstract

Today, microplastics are probably the most abundant and cardinal pollutant in soil and marine life. These particles are small and have a greater risk of endangering the ecosystem and human health. The use of plastic has become so abundant that it has spread over a wide area of ​​the sea and has now migrated and reached the human plate as well.

Aim: To study the inconspicuous invasion of microplastics from ocean to human placenta and breasts milk.

Objective: Detailed excavation of the literature available in this topic was done from various search engines, like google scholar, PubMed, Science direct. This study is an attempt to describe the reflection of different toxicological forms of microplastics in biotic and abiotic forms which may hamper the coming generations in the long run. Therefore, there is an urgent need to assess toxicity and biohazards to save our homes i.e. our "motherland".

Conclusion: The increasing environmental catastrophe with possible public health repercussions is highlighted by the discovery of microplastics in human breast milk and placenta, underscoring the urgent need for coordinated global efforts to minimise plastic pollution.

Keywords: Microplastics, human placenta, pollutants, ecosystem, biohazards

Keywords:

Microplastics, human placenta, pollutants, ecosystem, biohazards

DOI

https://doi.org/10.22270/jddt.v14i12.6923

Author Biographies

Anjali Mishra , Department of Pharmacy, Sarala Birla University, Mahilong, Ranchi, Jharkhand 835009

Department of Pharmacy, Sarala Birla University, Mahilong, Ranchi, Jharkhand 835009

Sudipta Modak , BCDA College of Pharmacy and Technology Campus-2, Madhyamgram, Kolkata, West Bengal, 700129

BCDA College of Pharmacy and Technology Campus-2, Madhyamgram, Kolkata, West Bengal, 700129

Shubhrojit Bhattacharjee , Department of Pharmacy, Jharkhand Rai University, Namkum, Ranchi, Jharkhand 835009

Department of Pharmacy, Jharkhand Rai University, Namkum, Ranchi, Jharkhand 835009

Rupam Vishwanaath , Department of Pharmacy, Jharkhand Rai University, Namkum, Ranchi, Jharkhand 835009

Department of Pharmacy, Jharkhand Rai University, Namkum, Ranchi, Jharkhand 835009

Anand Mohan , Department of Pharmacy, Jharkhand Rai University, Namkum, Ranchi, Jharkhand 835009

Department of Pharmacy, Jharkhand Rai University, Namkum, Ranchi, Jharkhand 835009

Bipin Kumar , Department of Pharmacy, Jharkhand Rai University, Namkum, Ranchi, Jharkhand 835009

Department of Pharmacy, Jharkhand Rai University, Namkum, Ranchi, Jharkhand 835009

References

1. Andrady AL. The plastic in microplastics: A review. Marine pollution bulletin. 2017., 15;119(1):12-22. DOI: doi.org/10.1016/j.marpolbul.2017.01.082

2. Hale RC, Seeley ME, La Guardia MJ, Mai L, Zeng EY. A global perspective on microplastics. Journal of Geophysical Research: Oceans. 2020;125(1):e2018JC014719. DOI: https://doi.org/10.1029/2018JC014719

3. Andrady AL. Microplastics in the marine environment. Marine pollution bulletin. 2011;62(8):1596-605. DOI: https://doi.org/10.1016/j.marpolbul.2011.05.030

4. Cox KD, Covernton GA, Davies HL, Dower JF, Juanes F, Dudas SE. Human consumption of microplastics. Environmental science & technology. 2019, 53(12):7068-74. DOI: https://doi.org/10.1021/acs.est.9b01517

5. Li J, Liu H, Chen JP. Microplastics in freshwater systems: A review on occurrence, environmental effects, and methods for microplastics detection. Water research. 2018., 15;137:362-74.DOI: https://doi.org/10.1016/j.watres.2017.12.056

6. Cole M, Lindeque P, Halsband C, Galloway TS. Microplastics as contaminants in the marine environment: a review. Marine pollution bulletin. 2011.,1;62(12):2588-97. DOI: https://doi.org/10.1016/j.marpolbul.2011.09.025

7. Silva AB, Bastos AS, Justino CI, da Costa JP, Duarte AC, Rocha-Santos TA. Microplastics in the environment: Challenges in analytical chemistry-A review. Analytica chimica acta. 2018.,9;1017:1-9. DOI: https://doi.org/10.1016/j.aca.2018.02.043

8. Shahnawaz M, Sangale MK, Ade AB. Bioremediation technology for plastic waste. (2019) pg. 11-9.

9. Zitko V, Hanlon MJ. Another source of pollution by plastics: skin cleaners with plastic scrubbers. Marine pollution bulletin. 1991;22(1):41-2. DOI: 10.1016/0025-326X(91)90444-W

10. Fendall LS, Sewell MA. Contributing to marine pollution by washing your face: microplastics in facial cleansers. Marine pollution bulletin. 2009. 1;58(8):1225-8. DOI: https://doi.org/10.1016/j.marpolbul.2009.04.025

11. Roy PK, Hakkarainen M, Varma IK, Albertsson AC. Degradable polyethylene: fantasy or reality. Environmental science & technology. 2011.15;45(10):4217-27. DOI: https://doi.org/10.1021/es104042f

12. Kaiser J. The dirt on ocean garbage patches. (2010) Pg: 1506. DOI: DOI: 10.1126/science.328.5985.1506

13. Turner A. Paint particles in the marine environment: an overlooked component of microplastics. Water rEsearch x. 2021. 1;12:100110. DOI: https://doi.org/10.1016/j.wroa.2021.100110

14. Moore CJ. Synthetic polymers in the marine environment: a rapidly increasing, long-term threat. Environmental research. 2008;108(2):131-9.DOI: https://doi.org/10.1016/j.envres.2008.07.025

15. Azoulay D, Villa P, Arellano Y, Gordon MF, Moon D, Miller KA, Thompson K, Kistler A. Plastic & health: the hidden costs of a plastic planet. Geneva: CIEL; 2019.

16. Galloway TS. Micro-and nano-plastics and human health. Marine anthropogenic litter. 2015:343-66.

17. Emenike EC, Okorie CJ, Ojeyemi T, Egbemhenghe A, Iwuozor KO, Saliu OD, Okoro HK, Adeniyi AG. From oceans to dinner plates: The impact of microplastics on human health. Heliyon. 2023;1;9(10)

18. Ragusa A, Notarstefano V, Svelato A, Belloni A, Gioacchini G, Blondeel C, Zucchelli E, De Luca C, D’Avino S, Gulotta A, Carnevali O. Raman microspectroscopy detection and characterisation of microplastics in human breastmilk. Polymers. 2022. 30;14(13):2700. DOI: 10.3390/polym14132700

19. Braun T, Ehrlich L, Henrich W, Koeppel S, Lomako I, Schwabl P, Liebmann B. Detection of microplastic in human placenta and meconium in a clinical setting. Pharmaceutics. 2021.22;13(7):921. DOI: https://doi.org/10.3390/pharmaceutics13070921

20. Liu S, Liu X, Guo J, Yang R, Wang H, Sun Y, Chen B, Dong R. The association between microplastics and microbiota in placentas and meconium: the first evidence in humans. Environmental science & technology. 2022 21;57(46):17774-85.: DOI: 10.1021/acs.est.2c04706

21. Barceló D, Picó Y, Alfarhan AH. Microplastics: Detection in human samples, cell line studies, and health impacts. Environmental toxicology and pharmacology. 2023 28:104204. DOI: https://doi.org/10.1016/j.etap.2023.104204

22. Leslie HA. Review of microplastics in cosmetics. IVM Institute for Environmental Studies. 2014;476:1-33.

23. Bureau ME. Report on the State of Environment of Macau, 2015. Internet].[cited 08th March 2018]. Available from: http://www. dspa. gov. mo/StateReportHTML/2016/index_en. htm. (2018)

24. Pironti C, Ricciardi M, Motta O, Miele Y, Proto A, Montano L. Microplastics in the environment: intake through the food web, human exposure and toxicological effects. Toxics. 2021.16;9(9):224. DOI: https://doi.org/10.3390/toxics9090224

25. Vethaak AD, Legler J. Microplastics and human health. Science. 2021.12;371(6530):672-4. DOI: DOI: 10.1126/science.abe5041

26. Prata JC, da Costa JP, Lopes I, Duarte AC, Rocha-Santos T. Environmental exposure to microplastics: An overview on possible human health effects. Science of the total environment. 2020.1;702:134455. DOI: https://doi.org/10.1016/j.scitotenv.2019.134455

27. Blackburn K, Green D. The potential effects of microplastics on human health: What is known and what is unknown. Ambio. 2022;51(3):518-30. DOI: https://doi.org/10.1007/s13280-021-01589-9

28. Smith M, Love DC, Rochman CM, Neff RA. Microplastics in seafood and the implications for human health. Current environmental health reports. 2018;5:375-86. DOI: https://doi.org/10.1007/s40572-018-0206-z

29. Santillo D, Miller K, Johnston P. Microplastics as contaminants in commercially important seafood species. Integrated environmental assessment and management. 2017;13(3):516-21. DOI: https://doi.org/10.1002/ieam.1909

30. Peñate CO. Microplastics in drinking water, food, and everyday products. Environmental Health Association of Québec (ASEQ-EHAQ). 2021.

31. Dusza HM, Katrukha EA, Nijmeijer SM, Akhmanova A, Vethaak AD, Walker DI, Legler J. Uptake, transport, and toxicity of pristine and weathered micro-and nanoplastics in human placenta cells. Environmental Health Perspectives. 2022;130(9):097006. DOI: https://doi.org/10.1289/EHP10873

Published

2024-12-15
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How to Cite

1.
Mishra A, Modak S, Bhattacharjee S, Vishwanaath R, Mohan A, Kumar B. The Invisible Threat: Microplastics in Human Blood and Placenta. J. Drug Delivery Ther. [Internet]. 2024 Dec. 15 [cited 2026 Feb. 12];14(12):202-5. Available from: https://jddtonline.info/index.php/jddt/article/view/6923

How to Cite

1.
Mishra A, Modak S, Bhattacharjee S, Vishwanaath R, Mohan A, Kumar B. The Invisible Threat: Microplastics in Human Blood and Placenta. J. Drug Delivery Ther. [Internet]. 2024 Dec. 15 [cited 2026 Feb. 12];14(12):202-5. Available from: https://jddtonline.info/index.php/jddt/article/view/6923