The Potential Protective Effects of Yellow Star on Comorbidity Risk Factors and Disorders Associated with Severe COVID-19 Outcomes

Authors

  • Guy Takuissu Centre for Food, Food Security and Nutrition Research (CRASAN), Institute for the Medical Research and Medicinal Plant Studies (IMPM), Ministry of Scientific Research and Innovation, Yaoundé, Cameroon https://orcid.org/0000-0002-7478-4165
  • Inelle Makamwe Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaounde 1, Yaounde, Cameroon https://orcid.org/0000-0003-1319-0168
  • Gildas Kamdem Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaounde 1, Yaounde, Cameroon https://orcid.org/0009-0008-6246-1407
  • Imelda Djuikoo Centre for Food, Food Security and Nutrition Research (CRASAN), Institute for the Medical Research and Medicinal Plant Studies (IMPM), Ministry of Scientific Research and Innovation, Yaoundé, Cameroon
  • Janvier Youovop Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaounde 1, Yaounde, Cameroon https://orcid.org/0000-0002-1598-6824
  • Rémy Orang Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaounde 1, Yaounde, Cameroon
  • Abraham Nkoué Laboratory of Microbiology, Department of Microbiology, University of Yaounde 1, Yaounde, Cameroon
  • Hippolyte Mouafo Centre for Food, Food Security and Nutrition Research (CRASAN), Institute for the Medical Research and Medicinal Plant Studies (IMPM), Ministry of Scientific Research and Innovation, Yaoundé, Cameroon https://orcid.org/0000-0002-0469-560X
  • Sylvain Sado Laboratory of Microbiology, Department of Microbiology, University of Yaounde 1, Yaounde, Cameroon https://orcid.org/0000-0003-2995-314X
  • Julius Oben Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaounde 1, Yaounde, Cameroon

Abstract

This study aimed to evaluate the effects of Yellow Star on some disorders and risk factors of comorbidity associated with COVID-19. These effects were evaluated in male and female rats by daily gavage (5 mL/Kg of body weight) for 7 and 14 days. The effects on the composition of the intestinal microbiota were evaluated in the feces, and the effects on coagulation, oxidative stress, lipid profile, and atherogenicity were assessed in plasma. Administration of Yellow Star inhibited the growth of Bacteroidetes and stimulated the growth of Bifidobacterium, Lactobacillus, and Lactococcus in both sexes. Yellow Star (p <0.05) inhibits coagulation in rats regardless of sex. We noted an increase in the antioxidant status and a decrease in pro-oxidant status in both sexes. At the same time, a decrease in plasma levels of MDA was noted. Finally, the administration of the Yellow Star resulted in a decrease in the plasma levels of triglycerides, total cholesterol, VLDL, total lipids, and the TC / HDL-c ratio; and an increase in HDL-c. At the end of this work, it seems justified to recommend the consumption of Yellow Star in the prevention and management of certain disorders accentuated by a SARS-CoV-2 infection.

Keywords: Yellow Star, COVID-19, dysbiosis, coagulation, oxidative stress, and dyslipidemias.

Keywords:

Yellow Star, COVID-19, dysbiosis, coagulation, oxidative stress, dyslipidemias

DOI

https://doi.org/10.22270/jddt.v14i9.6761

Author Biographies

Guy Takuissu, Centre for Food, Food Security and Nutrition Research (CRASAN), Institute for the Medical Research and Medicinal Plant Studies (IMPM), Ministry of Scientific Research and Innovation, Yaoundé, Cameroon

Cameroon Nutrition and Dietetic Research Center, Research and Development Department, J&A Oben Foundation, Yaoundé, Cameroon

Inelle Makamwe, Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaounde 1, Yaounde, Cameroon

Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaounde 1, Yaounde, Cameroon

Gildas Kamdem, Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaounde 1, Yaounde, Cameroon

Cameroon Nutrition and Dietetic Research Center, Research and Development Department, J&A Oben Foundation, Yaoundé, Cameroon

Imelda Djuikoo, Centre for Food, Food Security and Nutrition Research (CRASAN), Institute for the Medical Research and Medicinal Plant Studies (IMPM), Ministry of Scientific Research and Innovation, Yaoundé, Cameroon

Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaounde 1, Yaounde, Cameroon

Janvier Youovop, Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaounde 1, Yaounde, Cameroon

Cameroon Nutrition and Dietetic Research Center, Research and Development Department, J&A Oben Foundation, Yaoundé, Cameroon

Rémy Orang, Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaounde 1, Yaounde, Cameroon

Cameroon Nutrition and Dietetic Research Center, Research and Development Department, J&A Oben Foundation, Yaoundé, Cameroon

Abraham Nkoué, Laboratory of Microbiology, Department of Microbiology, University of Yaounde 1, Yaounde, Cameroon

Laboratory of Microbiology, Department of Microbiology, University of Yaounde 1, Yaounde, Cameroon

Hippolyte Mouafo, Centre for Food, Food Security and Nutrition Research (CRASAN), Institute for the Medical Research and Medicinal Plant Studies (IMPM), Ministry of Scientific Research and Innovation, Yaoundé, Cameroon

Centre for Food, Food Security and Nutrition Research (CRASAN), Institute for the Medical Research and Medicinal Plant Studies (IMPM), Ministry of Scientific Research and Innovation, Yaoundé, Cameroon

Sylvain Sado, Laboratory of Microbiology, Department of Microbiology, University of Yaounde 1, Yaounde, Cameroon

Laboratory of Microbiology, Department of Microbiology, University of Yaounde 1, Yaounde, Cameroon

Julius Oben, Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaounde 1, Yaounde, Cameroon

Cameroon Nutrition and Dietetic Research Center, Research and Development Department, J&A Oben Foundation, Yaoundé, Cameroon

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2024-09-15
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1.
Takuissu G, Makamwe I, Kamdem G, Djuikoo I, Youovop J, Orang R, et al. The Potential Protective Effects of Yellow Star on Comorbidity Risk Factors and Disorders Associated with Severe COVID-19 Outcomes. J. Drug Delivery Ther. [Internet]. 2024 Sep. 15 [cited 2026 May 25];14(9):21-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6761

Issue

Vol. 14 No. 9 (2024): Volume 14, Issue 9, September 2024

Section

Research

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How to Cite

1.
Takuissu G, Makamwe I, Kamdem G, Djuikoo I, Youovop J, Orang R, et al. The Potential Protective Effects of Yellow Star on Comorbidity Risk Factors and Disorders Associated with Severe COVID-19 Outcomes. J. Drug Delivery Ther. [Internet]. 2024 Sep. 15 [cited 2026 May 25];14(9):21-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6761
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