Qalaee (Stannum) metallic origin element, its chemical compounds, action, therapeutic uses, adverse effect and pharmacological activity studies: A Review

Authors

  • Dr. Raghubanshi Central Council for Research in Unani Medicine (CCRUM), New Delhi
  • Dr. Amir Central Council for Research in Unani Medicine (CCRUM), New Delhi
  • Mohd Tauseef Alam Research Associate (Unani), Central Research Institute of Unani Medicine (CRIUM), Lucknow, U.P., India.
  • Barkat Bari Technical Officer (Unani), Central Research Institute of Unani Medicine (CRIUM), Lucknow, U.P., India.
  • Najmus Sehar Research Officer (Unani), Central Research Institute of Unani Medicine (CRIUM), Lucknow, U. P India.
  • Ziaul Haq Siddiqi Research Officer (Unani), Central Research Institute of Unani Medicine (CRIUM), Lucknow, U. P India.
  • Arifa Khatoon Research Officer (Unani), Central Research Institute of Unani Medicine (CRIUM), Lucknow, U. P India.
  • Mohammad Idris Professor & Ex.Head, Post-Graduate Department of Ilmul Saidla (Unani Pharmaceutics), Ayurvedic & Unani Tibbia College & Hospital, Govt. NCT of Delhi, Karol Bagh, New Delhi-110 005, India.
  • Mohd Nafees Khan Deputy Director, Central Research Institute of Unani Medicine (CRIUM), Lucknow, U. P., India.
  • Jamal Akhtar Research Officer (Unani), Central Council for Research in Unani Medicine (CCRUM), New Delhi, India.

Abstract

Qalaee is Unani name of tin (stannum), which is a metallic element, belongs to group 14 of periodic table. Atomic number of tin is 50 and its atomic mass is 119. Qalaee (Tin) consist two types of compounds, inorganic tin compounds and organic tin compounds. Several toxic and adverse effect studies of Qalaee (stannum) have been reported such as, Respiratory Effects, Gastrointestinal Effects, Haematological Effects, Renal Effects, Dermal Effects, Ocular Effects, Immunological and Lymph reticular Effects, Neurological Effects, Cardiovascular Effects, Body weight effect and reproductive effects. Some studies on different pharmacological activities of tin also reported like, antibacterial activity, anticancer activity and anti-parasitic activity. In traditional system of medicine Qalaee is used in the form of Kusta or Bhasm for various disorders such as spermatorrhoea, excessive nocturnal emission, premature ejaculation and Syphilis etc. Its important Unani formulation is Kusta qalaee.

Keyword: Qalaee (Stannum), Action and Therapeutic use, adverse effect, Pharmacological action

Keywords:

Qalaee (Stannum), Action and Therapeutic use, adverse effect, Pharmacological action

DOI

https://doi.org/10.22270/jddt.v14i7.6686

Author Biographies

Dr. Raghubanshi, Central Council for Research in Unani Medicine (CCRUM), New Delhi

Research Officer (Unani), Central Research Institute of Unani Medicine (CRIUM), Lucknow, U. P India.

Dr. Amir, Central Council for Research in Unani Medicine (CCRUM), New Delhi

Research Associate (Unani), Central Research Institute of Unani Medicine (CRIUM), Lucknow, U.P., India.

Mohd Tauseef Alam, Research Associate (Unani), Central Research Institute of Unani Medicine (CRIUM), Lucknow, U.P., India.

Research Associate (Unani), Central Research Institute of Unani Medicine (CRIUM), Lucknow, U.P., India.

Barkat Bari, Technical Officer (Unani), Central Research Institute of Unani Medicine (CRIUM), Lucknow, U.P., India.

Technical Officer (Unani), Central Research Institute of Unani Medicine (CRIUM), Lucknow, U.P., India.

Najmus Sehar, Research Officer (Unani), Central Research Institute of Unani Medicine (CRIUM), Lucknow, U. P India.

Research Officer (Unani), Central Research Institute of Unani Medicine (CRIUM), Lucknow, U. P India.

Ziaul Haq Siddiqi, Research Officer (Unani), Central Research Institute of Unani Medicine (CRIUM), Lucknow, U. P India.

Research Officer (Unani), Central Research Institute of Unani Medicine (CRIUM), Lucknow, U. P India.

Arifa Khatoon, Research Officer (Unani), Central Research Institute of Unani Medicine (CRIUM), Lucknow, U. P India.

Research Officer (Unani), Central Research Institute of Unani Medicine (CRIUM), Lucknow, U. P India.

Mohammad Idris, Professor & Ex.Head, Post-Graduate Department of Ilmul Saidla (Unani Pharmaceutics), Ayurvedic & Unani Tibbia College & Hospital, Govt. NCT of Delhi, Karol Bagh, New Delhi-110 005, India.

Professor & Ex.Head, Post-Graduate Department of Ilmul Saidla (Unani Pharmaceutics), Ayurvedic & Unani Tibbia College & Hospital, Govt. NCT of Delhi, Karol Bagh, New Delhi-110 005, India.

Mohd Nafees Khan, Deputy Director, Central Research Institute of Unani Medicine (CRIUM), Lucknow, U. P., India.

Deputy Director, Central Research Institute of Unani Medicine (CRIUM), Lucknow, U. P., India.

Jamal Akhtar, Research Officer (Unani), Central Council for Research in Unani Medicine (CCRUM), New Delhi, India.

Research Officer (Unani), Central Council for Research in Unani Medicine (CCRUM), New Delhi, India.

References

Tin chemistry: Fundamental, Frontiers, and Applications Edited by Marcel Gielen,Alwyn Davies, Kieth Pannell and Edward Tiekink, John Wiley&Sons, Ltd. ISBN: 2008; 978-0-470-51771-0

WHO, Tin and inorganic tin compounds (Concise international chemical assessment document; (65)1.Tin - adverse effects 2. Tin compounds - adverse effects 3. Risk assessment 4. Environmental exposure I. International Programme on Chemical Safety II Series. ISBN 92 4 153065 0 (LC/NLM Classification: QV 618) ISSN: 2005; 1020-6167

Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Tin and Compounds (Update). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Services. 2005

Said M Hamdard Pharmacopoeia of Eastern Medicine, Second impression, Hamdard Academy, Krachi, 1970; 232-234.

Nadkarnni KM., Indian Materia Medica, Vol II, Popular Prakashan Pvt.Ltd Mumbai, 1982; 116-118.

Kabiruddin H. Byaz Kabir Vol 2nd Hikmat book depot Hyderabad Deccan, ynm; 117.

Kabiruddin H., Al Qarabaddin, 2nd edition, Central Council Research Unani Medicine, New Delhi, 2006; 547-549.

Kabiruddin H., Makhzanul Mufradat, Al-maroof Ba-Khwasul Advia, Ajaz publication house New Delhi, Ynm; 420

Anonymous, National Formulary of Unani Medicine Part I, Urdu Edition, Government of India, Health &Family Welfare (Deptt. of Health) New Delhi, 1993; 131-132

Budavari S, The Merck index. An encyclopedia of chemicals, drugs,and biologicals, 13th ed. Whitehouse Station, NJ, Merck and Co., Inc. ed, 2001

Ghani N, Khazain-ul-Advia, Idarakitab-ul-shifa; Dariya Ganj, New Delhi, 2011; 722-723.

Anonymous, Formulary of Unani medicine part- v, government of India ministry of health and family welfare department of Ayurveda, yoga & naturopathy, Unani, siddha and homoeopathy (Ayush) new Delhi, 2008; 57

Kapoor RC., Some observations on the metal-based preparations in the Indian system of medicine. Indian Journal of Traditional Knowledge, 2010; 9: 562-575.

Cutter HC, Faller WW, Stocklen JB, et al., Benign pneumoconiosis in a tin oxide recovery plant. J Ind Hyg, 1949; 31: 139-141

Dundon CC, Hughes JP., Stannic oxide pneumoconiosis. Am J Roentgenol Radium Ther, 1950; 63: 797

Pendergrass EP, Pryde AW., Benign pneumoconiosis due to tin oxide: A case report with experimental investigation of the radiographic density of the tin oxide dust. J Ind Hyg Tox, 1948; 30: 119-123.

Stewart JH, Lassiter JV., Tin. In: Bingham E, Cohrssen B, Powell CH, eds. Patty's Toxicology. 2001; 2: 576-597.

Rey C, Reinecke HJ, Besser R., Methyltin intoxication in six men: Toxicologic and clinical aspects. Vet Hum Toxicol 1984; 26: 121-122.

Wax PM, Dockstader L., Tributyltin use in interior paints: A continuing health hazard. Clin Toxicol, 1995; 33(3): 239-241. https://doi.org/10.3109/15563659509017990 PMid:7760448

Saary MJ, House RA. Preventable exposure to trimethyl tin chloride: a case report. Occup Med, 2002; 52(4): 227-230. https://doi.org/10.1093/occmed/52.4.227 PMid:12091590

Gohlke VR, Lewa W, Strachovsky A, et al., Animal experimental studies on the inhalatory effects of tributyltin chloride in a subchronic test. Gezamte Hyg, German, 1969; 15: 97-104

Iwamoto I. Experimental studies on the influence of butyltin poisoning through the respiratory tract upon the reproductive function.) J Tokyo Med College, Japanese, 1960; 18: 1351-1376

Igarashi I. Experimental studies on butyl-tin poisoning through respiratory tract and its prevention and treatment. J Tokyo Med College, Japanese, 1959;17: 1603-1632

WHO, Tin and organotin compounds: A preliminary review. Environmental Health criteria 15. World Health Organization, Geneva, Switzerland. 1980 http://www.inchem.org/documents/ehc/ehc.ehc015.htm. June 6, 2003

Fortemps E, Amand G, Bomboir A, et al., Trimethyltin poisoning. Report of two cases. Int Arch Occup Environ Health, 1978; 41: 1-6. https://doi.org/10.1007/BF00377794 PMid:627412

Ross WD, Emmett EA, Steiner J, et al., Neurotoxic effects of occupational exposure to organotins. Am J Psychiatry, 1981; 138: 1092-1095. https://doi.org/10.1176/ajp.138.8.1092 PMid:7258389

De Groot AP., Subacute toxicity of inorganic tin as influenced by dietary levels of iron and copper. Food Cosmet Toxicol, 1973;11: 955-962 https://doi.org/10.1016/0015-6264(73)90222-8 PMid:4783993

Funahashi N, Iwasaki I, Ide G., Effects of bis (tri-n-butyltin)oxide on endocrine and lymphoid, 1980 https://doi.org/10.1111/j.1440-1827.1980.tb03283.x PMid:6255740

Krajnc EI, Wester PW, Loeber JG, et al. Toxicity of bis (tri-n-butyltin) oxide in the rat. I. Short-term effects on general parameters and on the endocrine and lymphoid systems. Toxicol Appl Pharmacol, 1984; 75: 363-386. https://doi.org/10.1016/0041-008X(84)90176-5 PMid:6474469

Janssen PJM, Bosland MC, van Hees JP, et al., Effects of feeding stannous chloride on different parts of the gastrointestinal tract of the rat. Toxicol Appl Pharmacol, 1985; 78: 19-28 https://doi.org/10.1016/0041-008X(85)90300-X PMid:4035669

Ema M, Itami T, Kawasaki H.. Changes of spontaneous motor activity of rats after acute exposure to tributyltin chloride. Drug Chem Toxicol 1991b; 14: 161-171. https://doi.org/10.3109/01480549109017874 PMid:1889374

Noda T, Nakamura T, Shimizu M, et al., Critical gestational day of teratogenesis by di-n-butyltin diacetate in rats. Bull Environ Contam Toxicol, 1991b; 49(5): 715-722. https://doi.org/10.1007/BF00200785 PMid:1392311

Noda T, Yamano T, Shimizu M, et al., Comparative teratogenicity of din- butyltin diacetate with n-butyltin trichloride in rats. Arch Environ Contam Toxicol, 1992b ; 23: 216-222. https://doi.org/10.1007/BF00212278 PMid:1514842

Farr C.H, Reinisch K, Holson J.F, et al., Potential teratogenicity of di-n-butyltin dichloride and other dibutyltin compounds. Teratog Carcinog Mutagen,2001; 21: 405-415 https://doi.org/10.1002/tcm.1028 PMid:11746254

Umair S.M, Rehman S, Tajuddin, Siddiqi K.S, Nami SAA, Nanotization, Characterization and In-Vitro Activity of Kushta-E-Qalai (Tin Calx): A Traditional Unani Medicine of India. Pharm Anal Acta, 2015; 6: 388. doi:10.4172/21532435.1000388. https://doi.org/10.4172/2153-2435.1000388

Kovala-Demertzi D, Dokorou V, Primikiri A, Vargas R, Silvestru C, Russo U, Demertzis M.A, Inorg J., Biochem, 2009; 103: 738. https://doi.org/10.1016/j.jinorgbio.2009.01.014 PMid:19237201

Hussain H., N. Bibi, A. Al-Harrasi, S. Siddiqi, S.U. Kazmi, Y. Zhang, A. Badshah, Chin. Chem. Lett., 2012; 23: 731. https://doi.org/10.1016/j.cclet.2012.03.011

Barot G.V. ,Synthesis, Structural Characterization and Biological Studies of Organotin Polyethers (Sn-O), ed., Pro Quest, U.S.A., 2009

Michalik M, Kosinska I, Sroka J, Madeja Z, Przestalski S, Korohoda W, Acta Protozool, 2009; 40: 169.

Published

2024-07-15
Statistics
Abstract Display: 393
PDF Downloads: 560
PDF Downloads: 155

How to Cite

1.
Raghubanshi D, Amir D, Alam MT, Bari B, Sehar N, Siddiqi ZH, et al. Qalaee (Stannum) metallic origin element, its chemical compounds, action, therapeutic uses, adverse effect and pharmacological activity studies: A Review. J. Drug Delivery Ther. [Internet]. 2024 Jul. 15 [cited 2026 Jan. 22];14(7):136-41. Available from: https://jddtonline.info/index.php/jddt/article/view/6686

How to Cite

1.
Raghubanshi D, Amir D, Alam MT, Bari B, Sehar N, Siddiqi ZH, et al. Qalaee (Stannum) metallic origin element, its chemical compounds, action, therapeutic uses, adverse effect and pharmacological activity studies: A Review. J. Drug Delivery Ther. [Internet]. 2024 Jul. 15 [cited 2026 Jan. 22];14(7):136-41. Available from: https://jddtonline.info/index.php/jddt/article/view/6686

Most read articles by the same author(s)