Review on Callilstemon citrinus: Recent Approaches in Novel Drug Delivery System
callistemon citrinus novel drug delivery approaches.
Abstract
Callistemon citrinus is an ornamental plant. The plant is commonly originated in subtropical and tropical region. C.citrinus, commonly referred to as bottlebrush, is a member of myrtaceae family. Active ingreadients such as 1, 8-cineole, triterpenoids, α-pinenes, eucalyptol, tannis, alkaloids, flavonoids, saponins, phytosterol etc. are mostly found in the various plant sections. It is generally use in traditional, folk and herbal medicine as a water accent, anticough, antibronchtits, insecticide and treatment of diarrhoea, dysentery and rheumatism. This article aims to provide a comprehensive review on the pharmacological aspects and recent novel approaches of callistemon citrinus highlight methodologies, applications, and potential contributions of this natural extract in enhancing drug delivery, offering insights into its pharmacological potential and future prospects in the field. The primary objective to collect updated information about effectiveness of the plant extract in addressing specific health issues and its potential as a therapeutic effect using novel drug delivery systems. Innovative methods explored in delivering the plant extract, such as Nano formulations in various diseases i.e. Antifungal properties, acute toxicity, brine shrimp cytotoxicity and relaxant activity, antimicrobial Activity etc. The methods improve therapeutic efficacy and reduces side effects by optimizing the delivery of bioactive compounds from callistemon citrinus.
Keywords: Callistemon citrinus, Bottle brush, Pharmacological activities, Novel Drug Delivery Systems, Isolated compounds.
Keywords:
Callistemon citrinus, Bottle brush, Pharmacological activities, Novel Drug Delivery Systems, Isolated compoundsDOI
https://doi.org/10.22270/jddt.v14i6.6639References
Pharmacognostic study of Callistemon citrinus L. bark." Int J Pharm Pharm.
Phytochemical and Chemical composition evaluation of Volatile Oil of Callistemon linearis DC Leaf.
Goyal PK, Jain R, Jain S, Sharma A. A Review on biological and phytochemical investigation of plant genus Callistimon. Asian Pac J Trop Biomed. 2012 Jan;2(3):S1906-9. https://doi.org/10.1016/S2221-1691(12)60519-X
PR S, PATIL P, BAIRAGI V. PHARMACOGNOSTIC, PHYTOCHEMICAL PROPERTIES AND ANTIBACTERIAL ACTIVITY OF CALLISTEMON CITRINUS VIMINALIS LEAVES AND STEMS. International Journal of Pharmacy and Pharmaceutical Sciences, 2012;4(4):406-408
Cock I. Antimicrobial activity of Callistemon citrinus and Callistemon salignus methanolic extracts. Pharmacogn Commun. 2012 Jun 25;2(3):50-7. https://doi.org/10.5530/pc.2012.3.11
Mabhiza D, Chitemerere T, Mukanganyama S. Antibacterial Properties of Alkaloid Extracts from Callistemon citrinus and Vernonia adoensis against Staphylococcus aureus and Pseudomonas aeruginosa. Int J Med Chem. 2016 Jan 20;2016:1-7. https://doi.org/10.1155/2016/6304163 PMid:26904285 PMCid:PMC4745602
Firoz M, Bharatesh K, Nilesh P, Vijay G, Tabassum S, Nilofar N. Cardioprotective activity of ethanolic extract of Callistemon lanceolatus leaves on doxorubicin-induced cardiomyopathy in rats. Bangladesh J Pharmacol. 2011 Jun 10;6(1):38-45. https://doi.org/10.3329/bjp.v6i1.8154
Pendyala V, Thaakur S. PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF CALLISTEMON CITRINUS FOR ANTIDEPRESSANT ACTIVITY IN ALBINO MICE. Asian J Pharm Clin Res. 2017 Aug 1;10(8):232. https://doi.org/10.22159/ajpcr.2017.v10i8.18998
Kumar S, Kumar V, Prakash O. Antihyperglycemic, antihyperlipidemic potential and histopathological analysis of ethyl acetate fraction of Callistemon lanceolatus leaves extract on alloxan induced diabetic rats. J Exp Integr Med. 2011;1(3):185. https://doi.org/10.5455/jeim.010611.or.010
Bunalema L, Tabuti J, Sekagya Y, Ogwang S, Waako P. Anti-tubercular activity of Callistemon citrinus and Piptadenistrum africanum on resistant strains of Mycobacterium tuberculosis using Microplate alamar blue assay. Spatula DD - Peer Rev J Complement Med Drug Discov. 2015;5(4):235. https://doi.org/10.5455/spatula.20160316042034
Kumar S, Kumar V, Prakash O. Pharmacognostic study and anti-inflammatory activity of Callistemon lanceolatus leaf. Asian Pac J Trop Biomed. 2011 Jun;1(3):177-81. https://doi.org/10.1016/S2221-1691(11)60022-1 PMid:23569754
Sanjita Das and Uttam Singh*. Therapeutic potentials of Callistemon lanceolatus DC.
Dave P, The Correlation Between Stigma and Mental Health Disorders in People Living with HIV/AIDS, Journal of Drug Delivery and Therapeutics. 2024; 14(3):227-233. https://doi.org/10.22270/jddt.v14i3.6490
Ali N, Ahmed G, Ali Shah SW, Shah I, Ghias M, Khan I. Acute toxicity, brine shrimp cytotoxicity and relaxant activity of fruits of callistemon citrinus curtis. BMC Complement Altern Med. 2011 Dec;11(1):99. https://doi.org/10.1186/1472-6882-11-99 PMid:22024247 PMCid:PMC3216858
Léopold N Tatsadjieu PMJ. Correlation between chemical composition and antifungal properties of essential oils of Callistemon rigidus and Callistemon citrinus of Cameroon against Phaeoramularia angolensis.
Seyydnejad. Antibacterial Activity of Hydroalcoholic Extract of Callistemon citrinus and Albizia lebbeck. Am J Appl Sci. 2010 Jan 1;7(1):13-6. https://doi.org/10.3844/ajassp.2010.13.16
Ahmad K, Hafeez ZB, Bhat AR, Rizvi MA, Thakur SC, Azam A, et al. Antioxidant and apoptotic effects of Callistemon lanceolatus leaves and their compounds against human cancer cells. Biomed Pharmacother. 2018 Oct;106:1195-209. https://doi.org/10.1016/j.biopha.2018.07.016 PMid:30119188
Arora DS, Nim L, Kaur H. Antimicrobial Potential of Callistemon lanceolatus Seed Extract and its Statistical Optimization. Appl Biochem Biotechnol. 2016 Sep;180(2):289-305. https://doi.org/10.1007/s12010-016-2099-3 PMid:27179517
Park S, Lim W, Jeong W, Bazer FW, Lee D, Song G. Sideroxylin ( Callistemon lanceolatus ) suppressed cell proliferation and increased apoptosis in ovarian cancer cells accompanied by mitochondrial dysfunction, the generation of reactive oxygen species, and an increase of lipid peroxidation. J Cell Physiol. 2018 Nov;233(11):8597-604. https://doi.org/10.1002/jcp.26540 PMid:29904922
Shukla R, Singh P, Prakash B, Kumar A, Mishra PK, Dubey NK. Efficacy of essential oils of Lippia alba (Mill.) N.E. Brown and Callistemon lanceolatus (Sm.) Sweet and their major constituents on mortality, oviposition and feeding behaviour of pulse beetle, Callosobruchus chinensis L. J Sci Food Agric. 2011;n/a-n/a. https://doi.org/10.1002/jsfa.4453 PMid:21547925
el-Ansary A, Sammour EM, Soliman MS, Gawish FA. In vivo, attenuation of schistosome cercarial development and disturbance of egg laying capacity in Biomphalaria alexandrina using sublethal concentrations of plant molluscicides. J Egypt Soc Parasitol. 2001 Dec;31(3):657-69.
Chistokhodova N, Nguyen C, Calvino T, Kachirskaia I, Cunningham G, Howard Miles D. Antithrombin activity of medicinal plants from central Florida. J Ethnopharmacol. 2002 Jul;81(2):277-80. https://doi.org/10.1016/S0378-8741(02)00097-1 PMid:12065163
Sandhiya V, Ubaidulla U. A review on herbal drug loaded into pharmaceutical carrier techniques and its evaluation process. Future J Pharm Sci. 2020 Dec;6(1):51. https://doi.org/10.1186/s43094-020-00050-0
Permana AD, Utami RN, Courtenay AJ, Manggau MA, Donnelly RF, Rahman L. Phytosomal nanocarriers as platforms for improved delivery of natural antioxidant and photoprotective compounds in propolis: An approach for enhanced both dissolution behaviour in biorelevant media and skin retention profiles. J Photochem Photobiol B. 2020 Apr;205:111846. https://doi.org/10.1016/j.jphotobiol.2020.111846 PMid:32151785
Ortega-Pérez LG, Piñón-Simental JS, Magaña-Rodríguez OR, Lopéz-Mejía A, Ayala-Ruiz LA, García-Calderón AJ, et al. Evaluation of the toxicology, anti-lipase, and antioxidant effects of Callistemon citrinus in rats fed with a high fat-fructose diet. Pharm Biol. 2022 Dec;60(1):1384-93. https://doi.org/10.1080/13880209.2022.2099907 PMid:35938503 PMCid:PMC9361760
Petronilho S, Rocha SM, Ramírez-Chávez E, Molina-Torres J, Rios-Chavez P. Assessment of the terpenic profile of Callistemon citrinus (Curtis) Skeels from Mexico. Ind Crops Prod. 2013 Apr;46:369-79. https://doi.org/10.1016/j.indcrop.2013.02.012
López-Mejia A, Ortega-Pérez LG, Godinez-Hernández D, Nateras-Marin B, Meléndez-Herrera E, Rios-Chavez P. Chemopreventive effect of Callistemon citrinus (Curtis) Skeels against colon cancer induced by 1,2-dimethylhydrazine in rats. J Cancer Res Clin Oncol. 2019 Jun;145(6):1417-26. https://doi.org/10.1007/s00432-019-02905-3 PMid:30923945
Ortega-Pérez LG, Ayala-Ruiz LA, Magaña-Rodríguez OR, Piñón-Simental JS, Aguilera-Méndez A, Godínez-Hernández D, et al. Development and Evaluation of Phytosomes Containing Callistemon citrinus Leaf Extract: A Preclinical Approach for the Treatment of Obesity in a Rodent Model. Pharmaceutics. 2023 Aug 22;15(9):2178. https://doi.org/10.3390/pharmaceutics15092178 PMid:37765149 PMCid:PMC10535757
Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE. Biodegradable polymeric nanoparticles as drug delivery devices. J Controlled Release. 2001 Jan;70(1-2):1-20. https://doi.org/10.1016/S0168-3659(00)00339-4 PMid:11166403
Brigger I, Dubernet C, Couvreur P. Nanoparticles in cancer therapy and diagnosis. Adv Drug Deliv Rev. 2012 Dec;64:24-36. https://doi.org/10.1016/j.addr.2012.09.006
Kumbhani K, Agrawal Y. Drug Conjugated Nanomedicine as Prodrug Carrier. Nanosci Nanotechnol-Asia. 2013 Jul;11(6):86-84. https://doi.org/10.2174/22106812112039990001
Wang S, Su R, Nie S, Sun M, Zhang J, Wu D, et al. Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals. J Nutr Biochem. 2014 Apr;25(4):363-76. https://doi.org/10.1016/j.jnutbio.2013.10.002 PMid:24406273 PMCid:PMC3959237
Reliene R, Shirode A, Coon J, Nallanthighal S, Bharali D, Mousa S. Nanoencapsulation of pomegranate bioactive compounds for breast cancer chemoprevention. Int J Nanomedicine. 2015 Jan;475. https://doi.org/10.2147/IJN.S65145 PMid:25624761 PMCid:PMC4296962
Pal S, Tak YK, Song JM. Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli. Appl Environ Microbiol. 2007 Mar;73(6):1712-20. https://doi.org/10.1128/AEM.02218-06
PMid:17261510 PMCid:PMC1828795
Christopher JG, Saswati B, Ezilrani P. Optimization of Parameters for Biosynthesis of Silver Nanoparticles Using Leaf Extract of Aegle marmelos. Braz Arch Biol Technol. 2015 Oct;58(5):702-10. https://doi.org/10.1590/S1516-89132015050106
Rajakumar G, Gomathi T, Abdul Rahuman A, Thiruvengadam M, Mydhili G, Kim SH, et al. Biosynthesis and Biomedical Applications of Gold Nanoparticles Using Eclipta prostrata Leaf Extract. Appl Sci. 2016 Aug 9;6(8):222. https://doi.org/10.3390/app6080222
In vitro antioxidant, antimicrobial and cytotoxic activities and green biosynthesis of silver & gold nanoparticles using Callistemon citrinus leaf extract. J Appl Pharm Sci [Internet]. 2017 [cited 2024 Feb 17]; Available from: http://www.japsonline.com/abstract.php?article_id=2305
Thakor AS, Jokerst J, Zavaleta C, Massoud TF, Gambhir SS. Gold Nanoparticles: A Revival in Precious Metal Administration to Patients. Nano Lett. 2011 Oct 12;11(10):4029-36. https://doi.org/10.1021/nl202559p PMid:21846107 PMCid:PMC3195547
Huang X, El-Sayed MA. Gold nanoparticles: Optical properties and implementations in cancer diagnosis and photothermal therapy. J Adv Res. 2010 Jan;1(1):13-28. https://doi.org/10.1016/j.jare.2010.02.002
Rotimi L, Ojemaye MO, Okoh OO, Sadimenko A, Okoh AI. Synthesis, characterization, antimalarial, antitrypanocidal and antimicrobial properties of gold nanoparticle. Green Chem Lett Rev. 2019 Jan 2;12(1):61-8. https://doi.org/10.1080/17518253.2019.1569730
Larayetan R, Ojemaye MO, Okoh OO, Okoh AI. Silver nanoparticles mediated by Callistemon citrinus extracts and their antimalaria, antitrypanosoma and antibacterial efficacy. J Mol Liq. 2019 Jan;273:615-25. https://doi.org/10.1016/j.molliq.2018.10.020
Arruebo M, Valladares M, González-Fernández Á. Antibody-Conjugated Nanoparticles for Biomedical Applications. J Nanomater. 2009;2009:1-24. https://doi.org/10.1155/2009/439389
Robinson I, Tung LD, Maenosono S, Wälti C, Thanh NTK. Synthesis of core-shell gold coated magnetic nanoparticles and their interaction with thiolated DNA. Nanoscale. 2010;2(12):2624. https://doi.org/10.1039/c0nr00621a PMid:20967339
Ravichandran S, Paluri V, Kumar G, Loganathan K, Kokati Venkata BR. A novel approach for the biosynthesis of silver oxide nanoparticles using aqueous leaf extract of Callistemon lanceolatus (Myrtaceae) and their therapeutic potential. J Exp Nanosci. 2016 Apr 12;11(6):445-58. https://doi.org/10.1080/17458080.2015.1077534
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