Development and optimization of Lamotrigene containing Liposomal Transdermal Patches

  • Biswajit Chattopadhyay Department of Pharmacy, Bhopal Institute of Technology and Science, Pharmacy, Bhopal, M.P. https://orcid.org/0000-0001-8723-1079
  • Abhishek Kumar Jain Department of Pharmacy, Bhopal Institute of Technology and Science, Pharmacy, Bhopal, M.P.
  • Umesh Kumar Jain Department of Pharmacy, Bhopal Institute of Technology and Science, Pharmacy, Bhopal, M.P.

Abstract

Antiepileptic drugs are generally available as tablets for oral administration, but this can pose problems for patients who are unable to consume medications orally. Transdermal drug delivery is useful in such cases. There is therefore an unmet need for enhancement techniques with the potential of delivering high dose medications across the skin. The transdermal route of drug administration ensures systemic delivery of drug by applying a drug formulation onto intact as patch on healthy skin thus ensuring sustained drug release and bypass of first-pass metabolism. Transdermal drugs significantly deliver molecules in a potent quantity that overcome the conventional problems of oral dosing. Thus, the objective of the proposed study is to develop lamotrigene-loaded transdermal patch an effective substitute for the existing maintenance therapies used for controlling epileptic seizures. We embarked on the transdermal delivery of lamotrigene upon this scientific basis.


Keywords: Lamotrigene, Antiepilepsy, Transdermal patch, Liposomes, Vesicular system

Keywords: Lamotrigene, Antiepilepsy, Transdermal patch, Liposomes, Vesicular system

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Author Biographies

Biswajit Chattopadhyay, Department of Pharmacy, Bhopal Institute of Technology and Science, Pharmacy, Bhopal, M.P.

Department of Pharmacy, Bhopal Institute of Technology and Science, Pharmacy, Bhopal, M.P.

Abhishek Kumar Jain, Department of Pharmacy, Bhopal Institute of Technology and Science, Pharmacy, Bhopal, M.P.

Department of Pharmacy, Bhopal Institute of Technology and Science, Pharmacy, Bhopal, M.P.

Umesh Kumar Jain, Department of Pharmacy, Bhopal Institute of Technology and Science, Pharmacy, Bhopal, M.P.

Department of Pharmacy, Bhopal Institute of Technology and Science, Pharmacy, Bhopal, M.P.

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Chattopadhyay B, Jain AK, Jain UK. Development and optimization of Lamotrigene containing Liposomal Transdermal Patches. JDDT [Internet]. 15May2024 [cited 24Jun.2024];14(5):130-6. Available from: https://jddtonline.info/index.php/jddt/article/view/6546