Topical Minocycline Induced Bluish Black Hyperpigmentation in Acne Vulgaris Patient: The First Case Report of Topical Application

The First Case Report of Topical Application

  • S N Sujaya Chief Dermatology Consultant, Surgiderma Hospital Skin Hair Laser Plastic Surgery, HRBR layout, Bangalore, Karnataka – 560043.
  • V S Ranganath Chief Dermatology Consultant, Surgiderma Hospital Skin Hair Laser Plastic Surgery, HRBR layout, Bangalore, Karnataka – 560043.
  • B S Girish Pharm.D Intern, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences (Formerly PES College of Pharmacy), Electronic City Campus, Bangalore, Karnataka – 560100. https://orcid.org/0000-0003-1894-7852
  • Joel M Johns Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences (Formerly PES College of Pharmacy), Electronic City Campus, Bangalore, Karnataka – 560100. https://orcid.org/0000-0002-1689-2678
  • C S Meghana Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences (Formerly PES College of Pharmacy), Electronic City Campus, Bangalore, Karnataka – 560100. https://orcid.org/0009-0003-2104-8759

Abstract

Minocycline induced hyperpigmentation is an aesthetically unsetting adverse drug event. Oral minocycline inducing hyperpigmentation is common course, keeping in line with this topical minocycline 4% was formulated. A moderately built woman diagnosed with acne was prescribed with topical minocycline 4% Gel and after 15 days of application she noticed dark patches on applied areas which progressed into macules. On examination, it was found that the topical minocycline has induced Type I (Bluish Black) Hyperpigmentation. To the best of clinician’s knowledge, the drug was withdrawn and observed over a period of month. Post-withdrawal for 30-days the skin started to regain its original tone. Regardless of the fact that the topical formulation has been designed to reduce the drug contact with the systemic circulation and to decrease the side-effects, will the formulation succeed in providing the effective and safe therapy in acne patients?


Keywords: Topical Minocycline 4%, Hyperpigmentation, Type I, Bluish Black Pigmentation, Acne Vulgaris

Keywords: Topical Minocycline 4%, Hyperpigmentation, Type 1 Hyperpigmentation, Bluish Black Pigmentation, Acne Vulgaris

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Author Biographies

S N Sujaya, Chief Dermatology Consultant, Surgiderma Hospital Skin Hair Laser Plastic Surgery, HRBR layout, Bangalore, Karnataka – 560043.

Chief Dermatology Consultant, Surgiderma Hospital Skin Hair Laser Plastic Surgery, HRBR layout, Bangalore, Karnataka – 560043.

V S Ranganath, Chief Dermatology Consultant, Surgiderma Hospital Skin Hair Laser Plastic Surgery, HRBR layout, Bangalore, Karnataka – 560043.

Chief Dermatology Consultant, Surgiderma Hospital Skin Hair Laser Plastic Surgery, HRBR layout, Bangalore, Karnataka – 560043.

B S Girish, Pharm.D Intern, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences (Formerly PES College of Pharmacy), Electronic City Campus, Bangalore, Karnataka – 560100.

Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences (Formerly PES College of Pharmacy), Electronic City Campus, Bangalore, Karnataka – 560100.

Joel M Johns, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences (Formerly PES College of Pharmacy), Electronic City Campus, Bangalore, Karnataka – 560100.

Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences (Formerly PES College of Pharmacy), Electronic City Campus, Bangalore, Karnataka – 560100.

C S Meghana, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences (Formerly PES College of Pharmacy), Electronic City Campus, Bangalore, Karnataka – 560100.

Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences (Formerly PES College of Pharmacy), Electronic City Campus, Bangalore, Karnataka – 560100.

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1.
Sujaya SN, Ranganath VS, Girish BS, Johns JM, Meghana CS. Topical Minocycline Induced Bluish Black Hyperpigmentation in Acne Vulgaris Patient: The First Case Report of Topical Application. JDDT [Internet]. 15Apr.2024 [cited 12Jul.2024];14(4):4-. Available from: https://jddtonline.info/index.php/jddt/article/view/6515