Formulating and evaluating a gel that contains Eletriptan-loaded transferosomes
Abstract
Transdermal-vesicular drug delivery systems offer various advantages over conventional drug delivery systems, such as bypassing first-pass metabolism, site-specific delivery, reduced dosing frequency, and more. The objective of the present research involves the formulation and in-vitro evaluation of Eletriptan transferosomal gel to reduce dosing frequency. Transferosomes act as vehicles for on-site drug delivery, and they are vesicular systems with a flexible membrane. By formulating this type, we can achieve a higher concentration at the site of action, thereby reducing dosing frequency.
Fourier-transform infrared spectra revealed that there was no interaction between the drug and excipients. Transferosomal formulations were prepared by the thin-film hydration technique and were incorporated into 1.5% Carbopol gel. From the results, Formulation code-ET6, containing Lecithin: Tween-80, has higher entrapment efficiency and maximum drug release, and is hence considered the optimized formulation. Stability studies performed for optimized transferosomal gel formulations indicate that the prepared transferosomal gel has more stability at a lower temperature.
The conclusion is that, based on the above data, it is confirmed that the prepared Eletriptan transferosomal gels can be considered as one of the promising approaches to reducing dosing frequency and maintaining drug concentration at the desired site for a longer time.
Keywords: Transdermal drug delivery, Eletriptan, Transferosomes, Thin Film Hydration Method, Carbopol gel.
Keywords:
Transdermal drug delivery, Eletriptan, Transferosomes, Thin Film Hydration Method, Carbopol gelDOI
https://doi.org/10.22270/jddt.v14i2.6409References
Barry BW. "Novel mechanisms and devices to enable successful transdermal drug delivery." Eur J Pharm Sci. 2001;14(2):101-14.. https://doi.org/10.1016/S0928-0987(01)00167-1 PMid:11500256
Alexander, Dwivedi S, Ajazuddin TK, Giri, Saraf S, Tripathi DK. "Approaches for breaking the barriers of drug permeation through transdermal drug delivery." J Control Rel. 2012;164(1):26-40. https://doi.org/10.1016/j.jconrel.2012.09.017 PMid:23064010
Cevc G. "Lipid vesicles and other colloids as drug carriers on the skin." Adv Drug Deliv Rev. 2004;56(5):675-711. doi:10.1016/j.addr.2003.10.028. PMID: 15019752. https://doi.org/10.1016/j.addr.2003.10.028 PMid:15019752
Benson HA. "Transfersomes for transdermal drug delivery." Expert Opin Drug Deliv. 2006;3(6):727-37. https://doi.org/10.1517/17425247.3.6.727 PMid:17076595
Malakar J, Sen SO, Nayak AK, Sen KK. "Formulation, optimization, and evaluation of transferosomal gel for transdermal insulin delivery." Saudi Pharm J. 2012;20(4):355-63. https://doi.org/10.1016/j.jsps.2012.02.001 PMid:23960810 PMCid:PMC3744964
Tfelt-Hansen P, Vries PD, Saxena PR. "Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy." Drugs. 2000;60(6):1259-87. https://doi.org/10.2165/00003495-200060060-00003 PMid:11152011
Shelke, Santosh et al. "Thermoreversible nanoethosomal gel for the intranasal delivery of Eletriptan hydrobromide." Journal of Materials Science: Materials in Medicine. 2016;27(6). https://doi.org/10.1007/s10856-016-5713-6 PMid:27091045
Milton KA, Allen MJ, Abel S, Jenkins VC, James GC, Rance DJ, Eve MD. "The safety, tolerability, pharmacokinetics and pharmacodynamics of oral and intravenous Eletriptan, a potent and selective ''5-HT1D-like'' receptor partial agonist." Cephalalgia. 1997; 17:A414. https://doi.org/10.1177/00912700222011580 PMid:12017347
Thakur T, Jain P, Jain V. "Formulation development and evaluation of transferosomal gel." Journal of Drug Delivery and Therapeutics. 2018;8(5):168-177. https://doi.org/10.22270/jddt.v8i5.1826
Gupta A, Aggarwal G, Singla S, Arora R. "Transfersomes: a novel vesicular carrier for enhanced transdermal delivery of sertraline: development, characterization, and performance evaluation." Sci Pharm. 2012;80(4):1061-1080. https://doi.org/10.3797/scipharm.1208-02 PMid:23264950 PMCid:PMC3528046
Das, Sen SO, Maji R, Nayak AK, Sen KK. "Transferosomal gel for transdermal delivery of risperidone: Formulation optimization and ex vivo permeation." Journal of Drug Delivery Science and Technology. 2017; https://doi.org/10.1016/j.jddst.2017.01.006
Waghule T, Rapalli VK, Singhvi G, Manchanda P, Hans N, Dubey SK, Hasnain MS, Nayak AK. "Voriconazole loaded nanostructured lipid carriers based topical delivery system: QbD based designing, characterization, in-vitro and ex-vivo evaluation." Journal of drug delivery science and technology. 2019;52:303-15. https://doi.org/10.1016/j.jddst.2019.04.026
Aiyalu R, Govindarjan A, Ramasamy A. "Formulation and evaluation of topical herbal gel for the treatment of arthritis in animal model." Brazilian Journal of Pharmaceutical Sciences. 2016;52(3). https://doi.org/10.1590/s1984-82502016000300015
Bakhrushina Elena O, Anurova Maria N, Zavalniy Michael S, Demina Natalia B, Bardakov Alexander I, Krasnyuk Ivan. "Dermatologic Gels Spreadability Measuring Methods Comparative Study." Int J App Pharm. 2022;14(1):164-168. https://doi.org/10.22159/ijap.2022v14i1.41267
Phaldesai and Saiesh. "Formulation and Evaluation of Gel Containing Econazole Nitrate." International Journal of Universal Pharmacy and Bio Sciences. 2014;3(3):2319-8141.
Cojocaru V, Ranetti AE, Hinescu LG, Ionescu M, Cosmescu C, Postoarca AG, Cinteza LO. "Formulation and evaluation of in vitro release kinetics of na3cadtpa decorporation agent embedded in microemulsion-based gel formulation for topical delivery." Farmacia. 2015;63(5).
Shrotriya S, Ranpise N, Satpute P, Vidhate B. "Skin targeting of curcumin solid lipid nanoparticles-engrossed topical gel for the treatment of pigmentation and irritant contact dermatitis." Artif Cells Nanomed Biotechnol. 2018;46(7):1471-82. https://doi.org/10.1080/21691401.2017.1373659 PMid:28884598
Published



How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).