Preparation and Evaluation of Ketoprofen Loaded Mucoadhesive Microspheres

KETOPROFEN LOADED MUCOADHESIVE MICOSPHERES

  • Suman Pattanayak Department of Pharmaceutics, Haldia Institute of Pharmacy (An institute of ICARE), ICARE Complex, Hatiberia, Haldia, Purba Medinipur, West Bengal-721657, India
  • Lakshmi Kanta Kanthal Haldia Institute of Pharmacy (An Institute of ICARE), Hatiberia, Haldia, Purba Medinipur, West Bengal-721657, India
  • Tamanna Afnan Department of Pharmaceutics, Haldia Institute of Pharmacy (An institute of ICARE), ICARE Complex, Hatiberia, Haldia, Purba Medinipur, West Bengal-721657, India
  • Shalini Shukla Department of Pharmaceutics, Haldia Institute of Pharmacy (An institute of ICARE), ICARE Complex, Hatiberia, Haldia, Purba Medinipur, West Bengal-721657, India
  • Pritish Kumar Panda Haldia Institute of Pharmacy (An Institute of ICARE), Hatiberia, Haldia, Purba Medinipur, West Bengal-721657, India https://orcid.org/0000-0002-1422-5345

Abstract

The aim of the present study was to prepare and evaluate Ketoprofen loaded microspheres fabricated with sodium alginate and Carbopol 934 by ion gelation method which enhances the drug residence time into the stomach by adhering to the mucus layer of and control the rate of drug release for longer period of time. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used for its analgesic, anti-inflammatory, and antipyretic (fever-reducing) properties. It belongs to the propionic acid class of NSAIDs and is available in various formulations, including oral tablets, capsules, topical gels, creams, and as an injectable solution. In present study ketoprofen incorporates in mucoadhesive drug delivery system for utilizing its controlled drug delivery up to 12 hrs. In present study prepared microspheres were evaluated for- particle size, entrapment efficiency, percentage yield, morphology, mucoadhesive property, in-vitro drug release property.


Keywords: Mucoadhesive microspheres, NSAID, ion gelation method, ketoprofen

Keywords: Mucoadhesive microsphere, NSAID, ion gelation method, ketoprofen

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Author Biographies

Suman Pattanayak, Department of Pharmaceutics, Haldia Institute of Pharmacy (An institute of ICARE), ICARE Complex, Hatiberia, Haldia, Purba Medinipur, West Bengal-721657, India

Department of Pharmaceutics, Haldia Institute of Pharmacy (An institute of ICARE), ICARE Complex, Hatiberia, Haldia, Purba Medinipur, West Bengal-721657, India

Lakshmi Kanta Kanthal, Haldia Institute of Pharmacy (An Institute of ICARE), Hatiberia, Haldia, Purba Medinipur, West Bengal-721657, India

Department of Pharmaceutics, Haldia Institute of Pharmacy (An institute of ICARE), ICARE Complex, Hatiberia, Haldia, Purba Medinipur, West Bengal-721657, India

Tamanna Afnan, Department of Pharmaceutics, Haldia Institute of Pharmacy (An institute of ICARE), ICARE Complex, Hatiberia, Haldia, Purba Medinipur, West Bengal-721657, India

Department of Pharmaceutics, Haldia Institute of Pharmacy (An institute of ICARE), ICARE Complex, Hatiberia, Haldia, Purba Medinipur, West Bengal-721657, India

Shalini Shukla, Department of Pharmaceutics, Haldia Institute of Pharmacy (An institute of ICARE), ICARE Complex, Hatiberia, Haldia, Purba Medinipur, West Bengal-721657, India

Department of Pharmaceutics, Haldia Institute of Pharmacy (An institute of ICARE), ICARE Complex, Hatiberia, Haldia, Purba Medinipur, West Bengal-721657, India

Pritish Kumar Panda, Haldia Institute of Pharmacy (An Institute of ICARE), Hatiberia, Haldia, Purba Medinipur, West Bengal-721657, India

Department of Pharmaceutics, Haldia Institute of Pharmacy (An institute of ICARE), ICARE Complex, Hatiberia, Haldia, Purba Medinipur, West Bengal-721657, India

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Pattanayak S, Kanthal LK, Afnan T, Shukla S, Panda P. Preparation and Evaluation of Ketoprofen Loaded Mucoadhesive Microspheres. JDDT [Internet]. 15Jan.2024 [cited 25Feb.2024];14(1):4-. Available from: https://jddtonline.info/index.php/jddt/article/view/6353