Anti-inflammatory potential of artificial microcapsules containing thalidomide for use in treating Crohn's disease
Abstract
Crohn's disease is a chronic inflammatory bowel disease associated with an abnormal immune response in the gastrointestinal tract. Several studies demonstrate that thalidomide could be effective in the treatment of refractory Crohn's disease. However, its widespread use has been limited because of potential side effects. In the present study, we investigated the inhibitory activity of alginate-poly-L-lysine-alginate (APA) microcapsules containing thalidomide on Lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophage cells and on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced Crohn’s disease. Results showed that APA microcapsules containing thalidomide inhibited the release of pro-inflammatory cytokines in cell supernatant following LPS activation. Moreover, treatment with microencapsulated thalidomide decreased the level of TNF-α, IL-6 and IL-1β by 49.3%, 62.3% and 54.6% respectively in TNBS-treated mice. The present project validates the efficiency of APA microcapsules in providing a targeted delivery of thalidomide for treating chronic conditions such as Crohn’s disease.
DOI
https://doi.org/10.22270/jddt.v3i5.630Published
Abstract Display: 473 
PDF Downloads: 751 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.