Evaluation of Anti-Diabetic Activity of Zinc Oxide Nanoparticles of Gymnema sylvestre Extract on Wistar Rats

Authors

  • Sravani Gotteparthi Department of pharmacology, School of Pharmaceutical Sciences & Technologies, Institute of Science and Technology, Jawaharlal Nehru Technological University Kakinada, Kakinada-533003, AP, India https://orcid.org/0009-0000-6744-3883
  • Manvitha Kotaru Department of pharmacology, School of Pharmaceutical Sciences & Technologies, Institute of Science and Technology, Jawaharlal Nehru Technological University Kakinada, Kakinada-533003, AP, India https://orcid.org/0000-0001-9487-7126
  • S. Ashok Krishnan Department of pharmacology, School of Pharmaceutical Sciences & Technologies, Institute of Science and Technology, Jawaharlal Nehru Technological University Kakinada, Kakinada-533003, AP, India https://orcid.org/0000-0003-3867-0766
  • K. Sridevi Department of pharmacology, School of Pharmaceutical Sciences & Technologies, Institute of Science and Technology, Jawaharlal Nehru Technological University Kakinada, Kakinada-533003, AP, India https://orcid.org/0009-0001-9763-6026

Abstract

Diabetes mellitus is described as a metabolic disorder, which was characterised by high blood glucose levels, which were resulted due to insufficient insulin secretion. There were major complications related to diabetes mellitus. To evaluate the antidiabetic effect of Gymnema sylvestre Zinc Oxide Nanoparticles. Streptozotocin (STZ) of 50mg/kg is used for the induction of diabetes into Wistar rats. The animals were divided into 6 groups. Group-I represented as Control; Group-II represented as diabetic control (STZ ); Group-III represented as 5 mg/kg body weight of glibenclamide + diabetes; Group-IV represented as Gymnema sylvestre extract + diabetes; Group-V represented as 100 µg Gymnema sylvestre Zinc Oxide nanoparticles + diabetes; group-6-  Gymnema sylvestre Zinc Oxide Nanoparticles 200 µg + diabetes. The GsZnONPs were inspected to morphological properties using UV spectrophotometer and FTIR. The GsZnONPs shown characterization peak at 300nm. The study has shown that GsZnONPs treated group has shown reduced glucose concentration. The histo-pathological alterations were also studied in all experimental groups. The pathology results of GsZnONPs (200 µg) group has shown the regeneration of islets cells of pancreas. The research study has proved that Gymnema sylvestre ZnO NPs exerts antidiabetic properties.

Keywords: Diabetes, Gymnema sylvestre, Zinc Oxide nanoparticles

Keywords:

Gymnema sylvestre, Zinc Oxide nanoparticles, Diabetes

DOI

https://doi.org/10.22270/jddt.v13i11.6283

Author Biographies

Sravani Gotteparthi, Department of pharmacology, School of Pharmaceutical Sciences & Technologies, Institute of Science and Technology, Jawaharlal Nehru Technological University Kakinada, Kakinada-533003, AP, India

Department of pharmacology, School of Pharmaceutical Sciences & Technologies, Institute of Science and Technology, Jawaharlal Nehru Technological University Kakinada, Kakinada-533003, AP, India

Manvitha Kotaru, Department of pharmacology, School of Pharmaceutical Sciences & Technologies, Institute of Science and Technology, Jawaharlal Nehru Technological University Kakinada, Kakinada-533003, AP, India

Department of pharmacology, School of Pharmaceutical Sciences & Technologies, Institute of Science and Technology, Jawaharlal Nehru Technological University Kakinada, Kakinada-533003, AP, India

S. Ashok Krishnan, Department of pharmacology, School of Pharmaceutical Sciences & Technologies, Institute of Science and Technology, Jawaharlal Nehru Technological University Kakinada, Kakinada-533003, AP, India

Department of pharmacology, School of Pharmaceutical Sciences & Technologies, Institute of Science and Technology, Jawaharlal Nehru Technological University Kakinada, Kakinada-533003, AP, India

K. Sridevi, Department of pharmacology, School of Pharmaceutical Sciences & Technologies, Institute of Science and Technology, Jawaharlal Nehru Technological University Kakinada, Kakinada-533003, AP, India

Department of pharmacology, School of Pharmaceutical Sciences & Technologies, Institute of Science and Technology, Jawaharlal Nehru Technological University Kakinada, Kakinada-533003, AP, India

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Published

15-11-2023
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How to Cite

1.
Gotteparthi S, Kotaru M, Krishnan SA, Sridevi K. Evaluation of Anti-Diabetic Activity of Zinc Oxide Nanoparticles of Gymnema sylvestre Extract on Wistar Rats. J. Drug Delivery Ther. [Internet]. 2023 Nov. 15 [cited 2025 Feb. 14];13(11):31-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6283

How to Cite

1.
Gotteparthi S, Kotaru M, Krishnan SA, Sridevi K. Evaluation of Anti-Diabetic Activity of Zinc Oxide Nanoparticles of Gymnema sylvestre Extract on Wistar Rats. J. Drug Delivery Ther. [Internet]. 2023 Nov. 15 [cited 2025 Feb. 14];13(11):31-8. Available from: https://jddtonline.info/index.php/jddt/article/view/6283