Exploring the Therapeutic Potential: Phytochemistry and Pharmacology of Bryophyllum pinnatum

Authors

  • Saurabh Dhumane Assistant Professor, Department of Pharmaceutical Analysis, Samarth College of Pharmacy, Belhe, Pune, Maharashtra, India https://orcid.org/0009-0002-7463-5917
  • Tejas Naik Department of Pharmacy, Samarth College of Pharmacy, Belhe, Pune, Maharashtra, India https://orcid.org/0009-0009-5927-9601
  • Mahesh Shelke Department of Pharmacy, Samarth College of Pharmacy, Belhe, Pune, Maharashtra, India https://orcid.org/0009-0001-9728-661X
  • Kiran Dukare Department of Pharmacy, Samarth College of Pharmacy, Belhe, Pune, Maharashtra, India
  • Krushna Dhongade Department of Pharmacy, Samarth College of Pharmacy, Belhe, Pune, Maharashtra, India

Abstract

Bryophyllum pinnatum, a renowned medicinal plant with a rich history in various traditional medical practices, has been utilized for treating a range of ailments such as fever, smallpox, otitis, cough, asthma, headache, convulsion, and general debility. The plant's diverse secondary metabolites, including steroids, flavonoids, terpenoids, fatty acids, bufadienolides, proteins, peptides, vitamins, and polysaccharides, have been identified. Over the past thirty years, extensive research has unveiled the plant's pharmacological effects both in vivo and in vitro, demonstrating its antimicrobial, anti-ulcer, antihypertensive, antileishmanial, anti-cancer, antidiabetic, and immunomodulatory properties.

This comprehensive review aims to provide a consolidated overview of Bryophyllum pinnatum, encompassing its traditional uses, phytochemistry, and pharmacological studies. By presenting a wealth of information, this paper seeks to inspire further exploration into the potential beneficial applications of the plant. Additionally, it sheds light on the clinical uses and prospects of Bryophyllum pinnatum, offering valuable insights for future research endeavors.

Keywords: Bryophyllum pinnatum, Chemical Constituent, Biological activities, antioxidant effect, Therapeutic potential

Keywords:

Bryophyllum pinnatum, Chemical Constituent, Biological activities, antioxidant effect, Therapeutic potential

DOI

https://doi.org/10.22270/jddt.v14i2.6282

Author Biographies

Saurabh Dhumane, Assistant Professor, Department of Pharmaceutical Analysis, Samarth College of Pharmacy, Belhe, Pune, Maharashtra, India

Assistant Professor, Department of Pharmaceutical Analysis, Samarth College of Pharmacy, Belhe, Pune, Maharashtra, India

Tejas Naik, Department of Pharmacy, Samarth College of Pharmacy, Belhe, Pune, Maharashtra, India

Department of Pharmacy, Samarth College of Pharmacy, Belhe, Pune, Maharashtra, India

Mahesh Shelke, Department of Pharmacy, Samarth College of Pharmacy, Belhe, Pune, Maharashtra, India

Department of Pharmacy, Samarth College of Pharmacy, Belhe, Pune, Maharashtra, India

Kiran Dukare, Department of Pharmacy, Samarth College of Pharmacy, Belhe, Pune, Maharashtra, India

Department of Pharmacy, Samarth College of Pharmacy, Belhe, Pune, Maharashtra, India

Krushna Dhongade, Department of Pharmacy, Samarth College of Pharmacy, Belhe, Pune, Maharashtra, India

Department of Pharmacy, Samarth College of Pharmacy, Belhe, Pune, Maharashtra, India

References

Halberstein RA, Saunders AB. Traditional medical practices and medicinal plant usage on a Bahamian Island. Cult Med Psychiatry. 1978;2(2):177-203. https://doi.org/10.1007/BF00054583

Ahirwar K. Effective healthful medicinal plants as antilithiatic Agents. Journal of Pharmacognosy and Phytochemistry 2019; 8(3): 1849-1860

Choure K, Mukhija S, Gurnani C, Kumar V. Effect of PGRS on ornamental plant Bryophyllum pinnatum (LAM.) Kurz. Eur J Biomed Pharm Sci. 2016;3(1):348-53.

Monk R, Bushinski D. Kidney stones. In: Williams Textbook of Endocrinology. 2003;1411-25.

Pandhare RB, Shende RR, Avhad MS, Deshmukh VK, Mohite PB, Sangameswaran B, et al. Anti-urolithiatic activity of Bryophyllum pinnatum Lam. hydroalcoholic extract in sodium oxalate-induced urolithiasis in rats. J Tradit Complement Med. 2021;11(6):545-51. https://doi.org/10.1016/j.jtcme.2021.06.002 PMid:34765518 PMCid:PMC8572709

Souza L, Oliveira JP da S, Fernandes A da S, Macedo AF, Araujo-Lima CF, Felzenszwalb I. UHPLC-MS metabolomic profile and in silico pharmacokinetic approach of Kalanchoe daigremontiana Raym.-Hamet & H. Perrier aqueous extracts. J Pharm Biomed Anal. 2024;238. https://doi.org/10.1016/j.jpba.2023.115827 PMid:37951139

Sharma K, Chauhan ES. Comparative Study of Nutritional and Phytochemical Attributes of Andrographis paniculata, Bryophyllum pinnatum and Clitoria ternatea for Nutraceutical Applications. Curr Nutr Food Sci. 2018;15(6):600-7. https://doi.org/10.2174/1573401314666181024144113

Polya G. Biochemical Targets of Plant Bioactive Compounds : a Pharmacological Reference Guide to Sites of Action and Biological Effects. 2003;860. https://doi.org/10.1201/9780203013717 PMid:12901082

Ingole RD, Thalkari AB, Karwa PN, Zambare KK, Shinde PS. Bryophyllum pinnatum : A magical herb . Res J Pharmacogn Phytochem. 2020;12(3):162. https://doi.org/10.5958/0975-4385.2020.00027.8

Khurshid M. the Miracle Plant (Kalanchoe Pinnata): a Phytochemical and Pharmacological Review. 2015;(May 2011):2020.

Abd-El Maksoud H. Leaf Morphology of Some Species of Tribe Phaseoleae in Egypt. Egypt J Agric Sci. 2018;69(4):341-52. https://doi.org/10.21608/ejarc.2018.211698

Иванова ЛА, Вирачева ЛЛ. Семейство Crassulaceae J. St.-Hil. в коллекции оранжереи Полярно-альпийского ботанического сада. Проблемы Ботаники Южной Сибири И Монголии. 2019;1(18):584-8. https://doi.org/10.14258/pbssm.2019123

Embryology of Flowering Plants: Terminology and Concepts, Vol. 2. Embryol Flower Plants Terminol Concepts, Vol 2. 2005;

Fernandes JM, Cunha LM, Azevedo EP, Lourenço EMG, Fernandes-Pedrosa MF, Zucolotto SM. Kalanchoe laciniata and Bryophyllum pinnatum: an updated review about ethnopharmacology, phytochemistry, pharmacology and toxicology. Rev Bras Farmacogn. 2019;29(4):529-58. https://doi.org/10.1016/j.bjp.2019.01.012

Zeng X, Xi Y, Jiang W. Protective roles of flavonoids and flavonoid-rich plant extracts against urolithiasis: A review. Crit Rev Food Sci Nutr. 2019;59(13):2125-35. https://doi.org/10.1080/10408398.2018.1439880 PMid:29432040

Sethiya NK, Ahmed NM, Shekh RM, Kumar V, Kumar Singh P, Kumar V. Ethnomedicinal, phytochemical and pharmacological updates on Hygrophila auriculata (Schum.) Hiene: an overview. J Integr Med. 2018;16(5):299-311. https://doi.org/10.1016/j.joim.2018.07.002 PMid:30007830

Aguiar J, Gonçalves JL, Alves VL, Câmara JS. Chemical fingerprint of free polyphenols and antioxidant activity in dietary fruits and vegetables using a non-targeted approach based on quechers ultrasound-assisted extraction combined with UHPLC-PDA. Antioxidants. 2020;9(4). https://doi.org/10.3390/antiox9040305 PMid:32283793 PMCid:PMC7222190

Kamboj A, Saluja AK, Bryophyllum pinnatum (Lam.) Kurz.: Phytochemical and Pharmacological Profile: A Review. Pharmacognosy Reviews,2009,3,6,364-374

Zou D, Wang Q, Chen T, Sang D, Yang T, Wang Y, et al. Bufadienolides originated from toad source and their anti-inflammatory activity. Front Pharmacol. 2022;13. https://doi.org/10.3389/fphar.2022.1044027 PMid:36339575 PMCid:PMC9627299

Oufir M, Seiler C, Gerodetti M, Gerber J, Fürer K, Mennet-von Eiff M, et al. Quantification of Bufadienolides in Bryophyllum pinnatum Leaves and Manufactured Products by UHPLC-ESIMS/MS. Planta Med. 2015;81(12-13):1190-7. https://doi.org/10.1055/s-0035-1546126 PMid:26132852

Kolodziejczyk-Czepas J, Stochmal A. Bufadienolides of Kalanchoe species: an overview of chemical structure, biological activity and prospects for pharmacological use. Phytochem Rev. 2017;16(6):1155-71. https://doi.org/10.1007/s11101-017-9525-1 PMid:29200987 PMCid:PMC5696496

Veitch NC, Grayer RJ. Flavonoids and their glycosides, including anthocyanins. Nat Prod Rep. 2008;25(3):555-611. https://doi.org/10.1039/b718040n PMid:18497898

Nascimento LB dos S, Casanova LM, Costa SS. Bioactive Compounds from Kalanchoe Genus Potentially Useful for the Development of New Drugs. Life. 2023;13(3). https://doi.org/10.3390/life13030646 PMid:36983802 PMCid:PMC10058616

Fürer K, Simões-Wüst AP, Von Mandach U, Hamburger M, Potterat O. Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy. Planta Med. 2016;82(11-12):930-41. https://doi.org/10.1055/s-0042-106727 PMid:27220081

Kumar G, Kumar R, Rana H. The Pharmacological activities of mother of thousand (Kalanchoe pinnata). Res J Pharmacol Pharmacodyn. 2023;31-5. https://doi.org/10.52711/2321-5836.2023.00007

Muzitano MF, Tinoco LW, Guette C, Kaiser CR, Rossi-Bergmann B, Costa SS. The antileishmanial activity assessment of unusual flavonoids from Kalanchoe pinnata. Phytochemistry. 2006;67(18):2071-7. https://doi.org/10.1016/j.phytochem.2006.06.027 PMid:16930642

Yeshi K, Crayn D, Ritmejerytė E, Wangchuk P. Plant Secondary Metabolites Produced in Response to Abiotic Stresses Has Potential Application in Pharmaceutical Product Development. Molecules. 2022;27(1). https://doi.org/10.3390/molecules27010313 Mid:35011546 PMCid:PMC8746929

Vikas M, Anju D, Chhavi S, Singla C. An Update on Urolithiatic Plant Drugs as Alternative Treatment Option for Mitigation of Kidney Stones. Ann RSCB. 2020;24(2):507-37.

Nirumand MC, Hajialyani M, Rahimi R, Farzaei MH, Zingue S, Nabavi SM, et al. Dietary plants for the prevention and management of kidney stones: Preclinical and clinical evidence and molecular mechanisms. Int J Mol Sci. 2018;19(3). https://doi.org/10.3390/ijms19030765 PMid:29518971 PMCid:PMC5877626

Sonawani R, Singh K, Gupta PC. Kidney stone: A clinical review. IOSR J Pharm Biol Sci (IOSR-JPBS. 15(5):42-9.

Muzitano MF, Bergonzi MC, De Melo GO, Lage CLS, Bilia AR, Vincieri FF, et al. Influence of cultivation conditions, season of collection and extraction method on the content of antileishmanial flavonoids from Kalanchoe pinnata. J Ethnopharmacol. 2011;133(1):132-7. https://doi.org/10.1016/j.jep.2010.09.020 PMid:20883762

Akinpelu M, Gamade SM, Akinbo FSM, Adeniyi TD, TD Elizebeth TD, Obeagu EI, Histopathological and Biochemical Effect of Vitamin C and D on Phosphine-Induced Hepatotoxicity in Wistar Rats, Asian Journal of Dental and Health Sciences 2023;3(2):18-22 https://doi.org/10.22270/ajdhs.v3i2.40

Bhutya RK. Ayurvedic Medicinal Plants of India. Scientific Publishers, 2011;2:1-352.

Khalsa KPS, Tierra M. The Way of Ayurvedic Herbs: The Most Complete Guide to Natural Healing and Health with Traditional Ayurvedic Herbalism. 2008;29:189.

Sohgaura A, Bigoniya P, Nagar G, Pradesh M, Birendra Shrivastava I, Papiya Bigoniya C, et al. Diuretic potential of Cynodon dactylon, Emblica officinalis, Kalanchoe pinnata and Bambusa nutans. ~ 2895 ~ J Pharmacogn Phytochem. 2018;7(3):2895-900.

Patel S. Anti-Urolithiatic Activity Of Extracts of Plant - Mimosa Pudica L. In Rats. 2010;1-114.

Kumar A, Nandi MK, Kumar B, Kumar A, Kumar R, Singh AK, et al. Antiurolithiasis, Antioxidant, Anti-inflammatory, Analgesic, and Diuretic Activity of Ethanolic Extract of Seeds of Caesalpinia bonducella. Int J Pharm Investig. 2021;11(3):306-11. https://doi.org/10.5530/ijpi.2021.3.54

Maharana L, Dadhich OP. Review on role of herbal drug in the prevention and managment of kidney disease . An Int J Res AYUSH Allied Syst. 2016;3(1):500-8.

Dighade R, Ingole R, Ingle P, Gade A, Hajare S, Ingawale M. Nephroprotective effect of Bryophyllum pinnatum-mediated silver nanoparticles in ethylene glycol-induced urolithiasis in rat. IET Nanobiotechnology. 2021;15(3):266-76. https://doi.org/10.1049/nbt2.12011 PMid:34694671 PMCid:PMC8675820

Domino EF. Sites of Action of Some Central Nervous System Depressants. Annu Rev Pharmacol. 1962;2(1):215-50. https://doi.org/10.1146/annurev.pa.02.040162.001243

Pattewar S V. Kalanchoe Pinnata : Phytochemical and Pharmacological Profile. Int J Phytopharm. 2012;2(1). https://doi.org/10.7439/ijpp.v2i1.223

Hsu H, Sheth CC, Veses V. Herbal Extracts with Antifungal Activity against Candida albicans: A Systematic Review. Mini-Reviews Med Chem. 2020;21(1):90-117. https://doi.org/10.2174/1389557520666200628032116 PMid:32600229

Ogunshe AAO, Lawal OA, Iheakanwa CI. Effects of simulated preparations of plants used in Nigerian traditional medicine on Candida spp. associated with vaginal candidiasis. Ethnobot Res Appl. 2008;6:373-83. https://doi.org/10.17348/era.6.0.373-383

Stefanowicz-Hajduk J, Hering A, Gucwa M, Hałasa R, Soluch A, Kowalczyk M, et al. Biological activities of leaf extracts from selected Kalanchoe species and their relationship with bufadienolides content. Pharm Biol. 2020;58(1):732-40. https://doi.org/10.1080/13880209.2020.1795208 PMid:32715869 PMCid:PMC7470146

Bruschi ML, Dota KFD, Consolaro MEL, Svidzinski TIE. Antifungal activity of brazilian propolis microparticles against yeasts isolated from vulvovaginal candidiasis. Evidence-based Complement Altern Med. 2011;2011. https://doi.org/10.1093/ecam/neq029 PMid:21607012 PMCid:PMC3094883

Milad R, El-Ahmady S and Nasser Singab A. Genus Kalanchoe (Crassulaceae): A review of its ethnomedicinal, botanical, chemical and pharmacological properties. European J Med Plants. 2014;4(1):86-104. https://doi.org/10.9734/EJMP/2014/5901

Uboh F. Effect of Aqueous Extract of Psidium Guajava Leaves on Liver Enzymes, Histological Integrity and Hematological Indices in Rats. Gastroenterol Res. 2010; https://doi.org/10.4021/gr2010.02.174w PMid:27956982 PMCid:PMC5139837

Joshi B, Panda SK, Jouneghani RS, Liu M, Parajuli N, Leyssen P, et al. Antibacterial, Antifungal, Antiviral, and Anthelmintic Activities of Medicinal Plants of Nepal Selected Based on Ethnobotanical Evidence. Evidence-based Complement Altern Med. 2020;2020. https://doi.org/10.1155/2020/1043471 PMid:32382275 PMCid:PMC7193273

Kamboj A, Saluja AK. Bryophyllum pinnatum (Lam.) Kurz.: Phytochemical and pharmacological profile: A review. Pharmacogn Rev. 2009;3(6):364-74.

Ungogo MA, Ebiloma GU, Ichoron N, Igoli JO, de Koning HP, Balogun EO. A Review of the Antimalarial, Antitrypanosomal, and Antileishmanial Activities of Natural Compounds Isolated From Nigerian Flora. Front Chem. 2020;8. https://doi.org/10.3389/fchem.2020.617448 PMid:33425860 PMCid:PMC7786139

Raj S, Sasidharan S, Balaji SN, Dubey VK, Saudagar P. Review on natural products as an alternative to contemporary anti-leishmanial therapeutics. J Proteins Proteomics. 2020;11(2):135-58. https://doi.org/10.1007/s42485-020-00035-w

Silva-Silva JV, Moragas-Tellis CJ, Chagas M do S dos S, Souza PVR de, Souza C da SF de, Hardoim D de J, et al. Antileishmanial Activity of Flavones-Rich Fraction From Arrabidaea chica Verlot (Bignoniaceae). Front Pharmacol. 2021;12. https://doi.org/10.3389/fphar.2021.703985 PMid:34354593 PMCid:PMC8329660

Nardella F, Gallé J-B, Bourjot M, Weniger B, Vonthron-Sénécheau C. Antileishmanial and Antitrypanosomal Activities of Flavonoids. 2018;163-94. https://doi.org/10.1007/978-3-319-67045-4_7

Ophelia George L, Radha HR, Somasekariah B V. In vitro anti-diabetic activity and GC-MS analysis of bioactive compounds present in the methanol extract of Kalanchoe pinnata. Indian J Chem. 2018;57:1213-21.

Dhakar RC, Prajapati SK, Maurya SD, Tilak VK, Das MK, Das S, Verma KK, Jain N. Antioxidant Potential of Cordia dichotoma: A Review. Asian Journal of Dental and Health Sciences, 2021;1(1):19-23. https://doi.org/10.22270/ajdhs.v1i1.6

Nagajyothi PC, Prabhakar Vattikuti S V., Devarayapalli KC, Yoo K, Shim J, Sreekanth TVM. Green synthesis: Photocatalytic degradation of textile dyes using metal and metal oxide nanoparticles-latest trends and advancements. Crit Rev Environ Sci Technol. 2020;50(24):2617-723. https://doi.org/10.1080/10643389.2019.1705103

Korkina LG, Afanas'Ev IB. Antioxidant and Chelating Properties of Flavonoids. Adv Pharmacol. 1996;38(C):151-63. https://doi.org/10.1016/S1054-3589(08)60983-7 PMid:8895808

Mutha RE, Tatiya AU, Surana SJ. Flavonoids as natural phenolic compounds and their role in therapeutics: an overview. Futur J Pharm Sci. 2021;7(1). https://doi.org/10.1186/s43094-020-00161-8 PMid:33495733 PMCid:PMC7816146

Tomazetti J, Ávila DS, Oliveira Ferreira AP, Martins JS, Souza FR, Royer C, et al. Baker yeast-induced fever in young rats: Characterization and validation of an animal model for antipyretics screening. J Neurosci Methods. 2005;147(1):29-35. https://doi.org/10.1016/j.jneumeth.2005.03.002 PMid:16054514

Ferreira RT, Coutinho MAS, Malvar DDC, Costa EA, Florentino IF, Costa SS, et al. Mechanisms underlying the antinociceptive, antiedematogenic, and anti-inflammatory activity of the main flavonoid from kalanchoe pinnata. Evidence-based Complement Altern Med. 2014;2014. https://doi.org/10.1155/2014/429256 PMid:25580151 PMCid:PMC4279175

Owoyele BV, Oguntoye SO, Dare K, Alice B, Adeola E, Ayodele A, et al. Analgesic, anti-inflammatory and antipyretic activities from flavonoid fractions of Chromolaena odorata. J Med Plants Res. 2013;2(9):219-25.

FERNANDES JM. Bryophyllum pinnatum E Kalanchoe laciniata: ESTUDO FITOQUÍMICO, METABOLÔMICO E AVALIAÇÃO DA INIBIÇÃO DA ATIVIDADE FOSFOLIPÁSICA DA PEÇONHA DE Bothrops erythromelas DE EXTRATOS OBTIDOS SOB DIFERENTES CONDIÇÕES DE CULTIVO. Prog Retin Eye Res. 2019;561(3):S2-3.

Ball GL, McLellan CJ, Bhat VS. Toxicological review and oral risk assessment of terephthalic acid (TPA) and its esters: A category approach. Crit Rev Toxicol. 2012;42(1):28-67. https://doi.org/10.3109/10408444.2011.623149 PMid:22050403

Salami EO, Ozolua RI, Okpo SO, Eze GI, Uwaya DO. Studies on the anti-asthmatic and antitussive properties of aqueous leaf extract of Bryophyllum pinnatum in rodent species. Asian Pac J Trop Med. 2013;6(6):421-5. https://doi.org/10.1016/S1995-7645(13)60067-X PMid:23711699

Mahajan SG, Mehta AA. Effect of Moringa oleifera Lam. Seed extract on ovalbumin-induced airway inflammation in guinea pigs. Inhal Toxicol. 2008;20(10):897-909. https://doi.org/10.1080/08958370802027443 PMid:18686107

Carullo G, Cappello AR, Frattaruolo L, Badolato M, Armentano B, Aiello F. Quercetin and derivatives: Useful tools in inflammation and pain management. Future Med Chem. 2017;9(1):79-93. https://doi.org/10.4155/fmc-2016-0186 PMid:27995808

Thakur R, Jain N, Pathak R, Sandhu SS. Practices in wound healing studies of plants. Evidence-based Complement Altern Med. 2011;2011. https://doi.org/10.1155/2011/438056 PMid:21716711 PMCid:PMC3118986

Alfred S, Kimberlee T. Safety Profile and Effect on Libido of a Combined Bryophyllum pinnatum, Moringa oleifera and Vitamin C Phytotherapeutic Agent. Free Radicals Antioxidants. 2017;7(2):156-9. https://doi.org/10.5530/fra.2017.2.23

Pezzati M, Rossi S, Tronchin M, Dani C, Filippi L, Rubaltelli FF. Umbilical cord care in premature infants: the effect of two different cord-care regimens (salicylic sugar powder vs chlorhexidine) on cord separation time and other outcomes. Pediatrics. 2003;112(4). https://doi.org/10.1542/peds.112.4.e275 PMid:14523211

Poddar S, Sarkar T, Choudhury S, Chatterjee S, Ghosh P. International Journal of Botany Studies International Journal of Botany Studies Indian traditional medicinal plants: A concise review. WwwBotanyjournalsCom. 2020;5(September).

M. P, M. D, S. G, S.K. C. Phytomedicine: An ancient approach turning into future potential source of therapeutics. J Pharmacogn Phyther. 2011;3(2):27-37

Published

15-02-2024
Statistics
Abstract Display: 702
PDF Downloads: 378
PDF Downloads: 1375

How to Cite

1.
Dhumane S, Naik T, Shelke M, Dukare K, Dhongade K. Exploring the Therapeutic Potential: Phytochemistry and Pharmacology of Bryophyllum pinnatum. J. Drug Delivery Ther. [Internet]. 2024 Feb. 15 [cited 2025 Feb. 19];14(2):171-7. Available from: https://jddtonline.info/index.php/jddt/article/view/6282

How to Cite

1.
Dhumane S, Naik T, Shelke M, Dukare K, Dhongade K. Exploring the Therapeutic Potential: Phytochemistry and Pharmacology of Bryophyllum pinnatum. J. Drug Delivery Ther. [Internet]. 2024 Feb. 15 [cited 2025 Feb. 19];14(2):171-7. Available from: https://jddtonline.info/index.php/jddt/article/view/6282