A Review of Different Approaches for Improving Curcumin Bioavailability

Authors

Abstract

The creation and development of herbal nanoparticles have moved to the forefront of nanoformulation research. Curcumin is the most essential bioactive component of curcuma longa, a plant that has been utilized in traditional medicine for centuries. This chemical contains therapeutic properties that can be utilized to prevent and treat a wide range of ailments. Curcumin has proven therapeutic efficacy in the treatment of a range of human ailments, however, it has a limited bioavailability, which appears to be due to poor absorption, rapid metabolism, and rapid systemic clearance. As a result, nanotechnology is a revolutionary concept that can be used to curcumin solubility, stability, and bioavailability issues. This review examines contemporary developments in chemical and pharmaceutical technologies, as well as the utilization of innovative materials for medical applications.

Keywords: Curcumin, Nanotechnology, Nanoformulation, Bioavailability

Keywords:

Curcumin, Nanotechnology, Nanoformulation, Bioavailability

DOI

https://doi.org/10.22270/jddt.v13i12.6267

Author Biographies

Saurabh D. Joshi, Department of Pharmacology, Dr. Shivajirao Kadam College of Pharmacy, Kasbe Digraj, Maharashtra India- 416305

Department of Pharmacology, Dr. Shivajirao Kadam College of Pharmacy, Kasbe Digraj, Maharashtra India- 416305

Rohankumar Rajaram Chavan, Research Scholar, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra India- 415404.

Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India- 416013.

Asha S. Jadhav, Department of Pharmacology, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India- 416013.

Department of Pharmacology, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India- 416013.

Vishal H. Thorat, Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India- 416013.

Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India- 416013.

Kalyani V. Gaikwad, Department of Pharmaceutical Chemistry, Adarsh College of Pharmacy, Vita, Maharashtra, India

Department of Pharmaceutical Chemistry, Adarsh College of Pharmacy, Vita, Maharashtra, India

References

Abirami M, Raja MJ, Mekala P, Visha P, Preparation and characterization of nanocurcumin Suspension, International Journal of Science, Environment and Technology, 2018; 7(1):100 – 103. www.ijset.net

Jantarat C, bioavailability enhancement techniques of herbal medicine: a case example of curcumin, International Journal of Pharmacy and Pharmaceutical Sciences, 2013; 5(1): 493-500.

Zheng D, Huang C, Huang H, et al. Antibacterial Mechanism of Curcumin: A Review. Chem Biodivers. 2020; 17(8):e2000171. https://doi.org/10.1002/cbdv.202000171

Fadusa M C, Lau C, Bikhchandani J, Lynchc HT, Curcumin: An age-old anti-inflammatory and anti-neoplastic agent, Journal of Traditional and Complementary Medicine, 2017;7(3): 339-346. https://doi.org/10.1016/j.jtcme.2016.08.002

Jakubczyk K, Drużga A, Katarzyna J, Skonieczna-Żydecka K, Antioxidant Potential of Curcumin—A Meta-Analysis of Randomized Clinical Trials, Antioxidants 2020; 9(11): 1092. https://doi.org/10.3390/antiox9111092.

Ma C, Zhuang Z, Su Q, He J, Li H. Curcumin Has Anti-Proliferative and Pro-Apoptotic Effects on Tongue Cancer in vitro: A Study with Bioinformatics Analysis and in vitro Experiments. Drug Des Devel Ther. 2020; 14:509-518. https://doi.org/10.2147/DDDT.S237830

Mansouri K , Rasoulpoor S , Daneshkhah A , Abolfathi S , Salari N , Mohammadi M , Shervin S, Clinical effects of curcumin in enhancing cancer therapy: A systematic review, BMC Cancer, 2020; 20: 791.

Jiang L, Cai X, Li S, Miao Y, Yang X, Lin M, Chen L, He X and Weng Z, Hydroxyethyl Starch Curcumin Enhances Antiproliferative Effect of Curcumin Against HepG2 Cells via Apoptosis and Autophagy Induction, Front. Pharmacol. 2021; 12:755054. https://doi.org/10.3390/molecules17055972

Zhao G, Shi Y, Gong C, Liu T, Nan W, Ma L, Wu Z, Da C, Zhou K and Zhang H Curcumin Exerts Antinociceptive Effects in Cancer-Induced Bone Pain via an Endogenous Opioid Mechanism. Front.Neurosci. (2021); 15: 696861. https://doi.org/10.3389/fnins.2021.696861

Cheraghipour K, Marzban, A. Ezatpour B, Khanizadeh, S, Koshki J, Antiparasitic properties of curcumin: A review, AIMS Agriculture and Food, 2018; 3(4): 561-578. https://doi.org/10.3934/agrfood.2018.4.561

Cui L, Miao J, Cui L. Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species. ASM Journals Antimicrobial Agents and Chemotherapy 2007;51(2):488-494. https://doi.org/10.1128/AAC.01238-06

Marton LT, Pescinini-E-Salzedas LM, Camargo MEC, et al. The Effects of Curcumin on Diabetes Mellitus: A Systematic Review. Front Endocrinol (Lausanne). 2021; 12:669448. https://doi.org/10.3389/fendo.2021.669448

Ramaholimihaso T, Bouazzaoui F and Kaladjian A Curcumin in Depression: Potential Mechanisms of Action and Current Evidence—a Narrative Review. Front. Psychiatry, 2020; 11:572533, https://doi.org/10.3389/fpsyt.2020.572533 .

Lopresti AL, Smith SJ, Rea A, Michel S, Efficacy of a curcumin extract (Curcugen™) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study. BMC Complement Med Ther. 2021; 21(1):40. https://doi.org/10.1186/s12906-021-03220-6

Saifi B, Haftcheshmeh SM, Feligioni M, et al. An overview of the therapeutic effects of curcumin in reproductive disorders with a focus on the anti-inflammatory and immunomodulatory activities. Phytother Res. 2022; 36(2):808-823. doi:10.1002/ptr.7360

Dhivya S, Rajalakshmi AN, a review on the preparation methods of curcumin nanoparticles, Pharmatutor. 2018; 6(9): 6-10.

Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Molecular pharmaceutics, 2007; 4(6):807-818. https://doi.org/10.1021/mp700113r

Bodhankar MM, Chikhle S, Various approaches towards enhancement of bioavailability of curcumin – a potent phytochemical, World journal of pharmaceutical research, 2018; (1): 606-626. https://doi.org/10.20959/wjpr20191-13932

Chirio D, Gallarate M, Peira E, Battaglia L, Serpe L, Trotta M. Formulation of curcumin-loaded solid lipid nanoparticles produced by fatty acids coacervation technique. J. Microencapsul, 2011: 28(6): 537-548. https://doi.org/10.3109/02652048.2011.590615

Chin SF, AkmarMohd Yazid SN, and Pang SC. Preparation and Characterization of Starch Nanoparticles for Controlled Release of Curcumin. Int. J. of Polymer Science, 2014; 8. https://doi.org/10.1155/2014/340121

Yallapu MM, Gupta BK, Jaggi M, Chauhan SC, Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells. J. Colloid Interface Sci., 2010: 351(1): 19. https://doi.org/10.1155/2014/340121

Sari TP, Mann B, Sharma R, Kumar R, Vikrant N, Process Optimization for the Production of Nanoencapsulated Curcumin and Analysis for Physicochemical Characteristics and Antioxidant Mechanism, Int. J of Biotechnology and Bioengineering Research, 2013; 4(6): 581-586.

Leimann FV, Cardozo L, Sayer C, and Araújo PH. Poly(3-hydroxybutyrate-co-3- hydroxyvalerate) nanoparticles prepared by a miniemulsion/solvent evaporation technique: Effect of PHBV molar mass and concentration. Brazilian Journal of Chemical Engineering, 2013; 30(2): 369-377. https://doi.org/10.1590/S0104-66322013000200014

Lin CC, Stability and characterization of phospholipid-based curcumin-encapsulated microemulsions. Food Chem, 2009; 116(4): 923-928.

Giat L, Sinh DT, Toan TP. High concentration Nanacurcumin fabrication by wet milling method curcumin with glassball. International Journal of Scientific & Technology research, 2014; 3(8): 345-348.

Moorthi C, Krishnan K, Manavalan R, Kathiresan K, Preparation and characterization of curcumin-piperine dual drug loaded nanoparticles. Asian Pacific Journal of Tropical Biomedicine, 2012; 2(11): 841-848. https://doi.org/10.1016/S2221-1691(12)60241-X

Chabib L, Martien R, Ismail H, Formulation of nanocurcumin using low viscosity chitosan polymer and its cellular uptake study into T47D cells. Indonesian J. Pharm, 2012; 23(1): 27-35.

Zhang H, Zhang L, Yuan P, Wang C, Preparation and in vitro release characteristics of curcumin in nanosuspensions. Zhongguo Zhong Yao Za Zhi, Chinese, 2011; 36(2): 132-135.

Yadav D, Kumar N, Nanonization of curcumin by antisolvent precipitation: Process development, characterization, freeze-drying, and stability performance. Int J Pharm, 2014; 477(1-2): 564-77.

Farrukh A, Radha M, Jeyaprakash J, Manicka V, Bioavailability of phytochemicals and its enhancement by drug delivery systems. Cancer Lett, 2013; 334(1): 133-141.

Malam Y, Loizidou M, Seifalian AM, Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer. Trends in Pharmacological Sciences, 2009; 30: 592-599.

Li L, Braiteh FS, and Kurzrock R, Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis, Cancer, American Cancer Society, 2005: 104: 322-331.

Rahman S, Cao S, Steadman KJ, Wei M, Parekh HS. Native and ????-cyclodextrin-enclosed curcumin: entrapment within liposomes and their in vitro cytotoxicity in lung and colon cancer, Drug Delivery, 2012; 19: 346-353. https://doi.org/10.3109/10717544.2012.721143

Chen Y, Wu Q, Zhang Z, Yuan L, Liu X, Zhou L. Preparation of curcumin-loaded liposomes and evaluation of their skin permeation and pharmacodynamics. Molecules. 2012; 17(5):5972-5987. https://doi.org/10.3390/molecules17055972

Prasad S, Tyagi AK, Aggarwal BB. Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer Res Treat. 2014; 46(1):2-18. https://doi.org/10.4143/crt.2014.46.1.2

Li C, Zhang Y, Su T, Feng L, Long Y, Chen Z. Silica-coated flexible liposomes as a nanohybrid delivery system for enhanced oral bioavailability of curcumin. International Journal of Nanomedicine, 2012; 7:5995-6002. https://doi.org/10.2147/IJN.S38043

Khan AD, Singh L. Various techniques of bioavailability enhancement: a review. Journal of drug delivery & therapeutics.2016; 6(3):34-41. https://doi.org/10.22270/jddt.v6i3.1228.

Li L, Braiteh FS, Kurzrock R. Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer. 2005; 104(6):1322-1331. https://doi.org/10.1002/cncr.21300

Wang W, Zhu R, Xie Q, et al. Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles. International Journal of Nanomedicine, 2012; 7: 3667-3677. https://doi.org/10.2147/IJN.S30428

Aqil F, Munagala R, Jeyabalan J, Vadhanam MV. Bioavailability of phytochemicals and its enhancement by drug delivery systems. Cancer Lett. 2013; 334(1):133-141. https://doi.org/10.1016/j.canlet.2013.02.032

Liu L, Sun L, Wu Q, et al. Curcumin-loaded polymeric micelles inhibit breast tumor growth and spontaneous pulmonary metastasis. International Journal of Pharmaceutics, 2013; 443(1-2):175-182. https://doi.org/10.1016/j.ijpharm.2012.12.032

Tran LD, Hoang NMT, Mai TT. Nanosized magnetofluorescent Fe3O4-curcumin conjugate for multimodal monitoring and drug targeting, Colloids and Surfaces, 2010; 371: 104-112. https://doi.org/10.1016/j.colsurfa.2010.09.011

Singh DK, Jagannathan R, Khandelwal P, Abraham PM, Poddar P. In situ synthesis and surface functionalization of gold nanoparticles with curcumin and their antioxidant properties: An experimental and density functional theory investigation. Nanoscale, 2013; 5: 1882-1893. https://doi.org/10.1039/c2nr33776b

Manju S and Sreenivasan K. Gold nanoparticles generated and stabilized by water-soluble curcumin-polymer conjugate: Blood compatibility evaluation and targeted drug delivery onto cancer cells. Journal of Colloid and Interface Science, 2012; 368 (1): 144-151. https://doi.org/10.1016/j.jcis.2011.11.024

Zhou H, Wu X, Xu W, Yang J, Yang Q. Fluorescence enhancement of the silver nanoparticles-curcumin-cetyl trimethyl ammonium bromide-nucleic acids system and its analytical application. Journal of Fluorescence, 2010; 20(4):843-850. https://doi.org/10.1007/s10895-010-0627-z

Challa R, Ahuja A, Ali J, Khar RK. Cyclodextrins in drug delivery: an updated review. Aaps Pharmscitech, 2005; 6(2):E329-E357. https://doi.org/10.1208/pt060243

Thompson DO. Cyclodextrins – enabling excipients: their present and future use in pharmaceuticals. Crit Rev Ther Drug Carrier Syst., 1997; 14(1):1-104.

Stella VJ, Rajewski RA. Cyclodextrins: their future in drug formulation and delivery. Pharm Res., 1997; 14(5):556-567. https://doi.org/10.1023/a:1012136608249

Loftsson T, Stefánsson E. Cyclodextrins and topical drug delivery to the anterior and posterior segments of the eye. Int J Pharm. 2017; 531(2):413-423. https://doi.org/10.1016/j.ijpharm.2017.04.010

Harris D, Robinson JR. Drug delivery via the mucous membranes of the oral cavity. J Pharm Sci., 1992; 81(1):1-10. https://doi.org/10.1002/jps.2600810102

Uekama K, Otagiri M. Cyclodextrins in drug carrier systems. Crit Rev Ther Drug Carrier Syst., 1987; 3(1):1-40.

Haller DG, Glick JH. Progestational agents in advanced breast cancer: an overview. Semin Oncol, 1986; 13(4 Suppl 4):2-8.

Schlegel PN, Efficacy and safety of histrelin subdermal implant in patients with advanced prostate cancer. J Urol, 2006; 175(4):1353-1358. doi:10.1016/S0022-5347(05)00649-X

Vadhanam MV, Ravoori S, Aqil F, Gupta RC. Chemoprevention of mammary carcinogenesis by sustained systemic delivery of ellagic acid. Eur J Cancer Prev., 2011; 20(6):484-491. https://doi.org/10.1016/j.canlet.2013.02.032

Published

2023-12-15
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How to Cite

1.
Joshi SD, Chavan RR, Jadhav AS, Thorat VH, Gaikwad KV. A Review of Different Approaches for Improving Curcumin Bioavailability. J. Drug Delivery Ther. [Internet]. 2023 Dec. 15 [cited 2026 Jan. 23];13(12):238-44. Available from: https://jddtonline.info/index.php/jddt/article/view/6267

How to Cite

1.
Joshi SD, Chavan RR, Jadhav AS, Thorat VH, Gaikwad KV. A Review of Different Approaches for Improving Curcumin Bioavailability. J. Drug Delivery Ther. [Internet]. 2023 Dec. 15 [cited 2026 Jan. 23];13(12):238-44. Available from: https://jddtonline.info/index.php/jddt/article/view/6267