Exploring Drug Prescription Patterns in the Neurology Department of a Tertiary Care Hospital: A Comprehensive Analysis
: A COMPREHENSIVE ANALYSIS
Abstract
Objective: Neurological disorders are a major cause of morbidity, mortality and disability. These adversely affect the quality of life among all age group patients. Majority of neurological disorders include Epilepsy, Headache, Cerebrovascular disorders with hemiparesis, Neuropathic pain, Extrapyramidal syndrome, Cervical myelopathy and Parkinson’s disease. This study was done with aim to evaluate the prescription pattern of various drugs in different types of neurological disorders and to use the WHO / INRUD prescribing indicators to assess the rational drug prescribing.
Materials and Methods: A Prescription-based, Observational prospective study was carried out in a tertiary care hospital at South India. The prescription data of patients attending the neurology outpatient department was analysed over a period of 2 months. Rational use of drugs was analysed by the INRUD Scale.
Results: Out of these, 166 patients were male, whereas 134 patients were female. Most prevalent neurological disorders were Trigeminal neuralgia (25.66%), 9.97% of the patient population received injections, with 4% receiving Inj. Dexamethasone 8mg. Overall drug prescribing performance scoring was 3.55.
Conclusion: Our study revealed good Prescribing pattern as shown by WHO scale- IRUD/INRUD. Further such studies with large sample size are needed so as to guide clinicians toward rationale drug.
Keywords: Neurological; International Network of Rational Use of Drugs; Drug Utilisation, Rational Use.
Keywords:
Neurological, International Network of Rational Use of Drugs, Drug Utilisation, Rational UseDOI
https://doi.org/10.22270/jddt.v13i7.6139References
Namboodiri KK, Samuel BP, Sarada AK, Nair SN, Venugopal K. Spectrum of Disease and Prescription Pattern for Outpatients Attending a Neurology Clinic in Kerala, India. Adv Neurol. 1991; 55:25-31. https://doi.org/10.1159/000481812
Bajaj JK, Muralidharan J, Jacob A, Acharya R, Kamath A, Gopalakrishnan M. Prescribing pattern in the outpatient department of neurosurgery in a tertiary care hospital of North India. Indian J Surg. 2019; 81(2):148-153. https://doi.org/10.1007/s12262-018-1830
Giri DK, Kanungo S, Panda S, Bhattacharya SK, Tripathy SK, Sarangi AK. Prescription pattern in the general outpatient department of a tertiary care teaching hospital in Eastern India. Indian J Health Sci Res. 2017; 7(12):86-91. https://doi.org/10.4103/picr.picr_86_17
Carneiro CF, Martins RS, Moura JAB, et al. Prescrição de medicamentos no ambulatório de neurologia do Hospital Universitário Walter Cantídio, Fortaleza, Ceará .Prescription of medications in the neurology outpatient clinic of the Walter Cantídio University Hospital, Fortaleza, Ceará. Rev Bras Educ Med. 2008; 32(3):345-350. https://doi.org/10.1007/s11096-015-0224-y
Tabassum R, Hussain SS, Arif SH, Ramzan A, Farhat S. Prescribing pattern in outpatient department of neurosurgery in a tertiary care hospital of North India. Int J Res Med Sci. 2019Jul; 7(7):2798-2802. https://doi.org/10.18203/2320-6012.ijrms20192922
Sahib Uddin, Farhat S. Prescribing pattern in outpatient department of neurosurgery in a tertiary care hospital of North India. Int J Res Med Sci. 2019 Jul; 7(7):2798-2802. https://doi.org/10.18203/2320-6012.ijrms20192922
Clayton JA. Sex influences in neurological disorders: case studies and perspectives. Dialogues Clin Neurosci. 2016 Dec; 18(4):357-360. https://doi.org/10.31887%2FDCNS.2016.18.4%2Fjclayton PMID: 28179807; PMCID: PMC5286721.
Dong X: Elder abuse: Research, practice, and health policy. The 2012 GSA Maxwell Pollack award lecture. Gerontologist 2013; 54:153–162. https://doi.org/10.1093/geront/gnt139
García-Azorín D, Neurological Comorbidity Is a Predictor of Death in Covid-19 Disease: A Cohort Study on 576 Patients. Front. Neurol. 11:781. https://doi.org/10.3389%2Ffneur.2020.00781
Kaul S, Bandaru VC, Suvarna A, Boddu DB: Stroke burden and risk factors in developing countries with special reference to India. J Indian Med Assoc 2009; 107:367–370. https://doi.org/10.1159/000445944
Thakur KT, Albanese E, Giannakopoulos P, et al. Neurological Disorders. In: Patel V, Chisholm D, Dua T, et al., editors. Mental, Neurological, and Substance Use Disorders: Disease Control Priorities, Third Edition (Volume 4). Washington (DC): The International Bank for Reconstruction and Development / The World Bank; 2016 Mar 14. Chapter 5. https://doi.org/10.1596/978-1-4648-0426-7
Mateen FJ, Dua T, Steiner T, Saxena S: Headache disorders in developing countries: research over the past decade. Cephalalgia 2008; 28:1107–1114. https://doi.org/10.1111/j.1468-2982.2008.01681.x
Rosenberg EC, Tsien RW, Whalley BJ, Devinsky O: Cannabinoids and Epilepsy. Neurotherapeutics 2015; 12:747–768. https://doi.org/10.3390/molecules28062805
Toth C. Pregabalin: latest safety evidence and clinical implications for the management of neuropathic pain. Ther Adv Drug Saf. 2014 Feb; 5(1):38-56. https://doi.org/10.1177/2042098613505614 PMID: 25083261; PMCID: PMC4110876.
Kuriakose C, Shifafiya MN, Sekar V, Kumar RS: To evaluate the prevalence and drug prescribing trends in stroke patients: a retrospective study. Int J Che Pharmace Sci 2014; 5:22–26. https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.06.022
Murthy NV, Anusha B, Perumal P: A Study on trends in prescribing pattern of anti-epileptic drugs in teritiary care teaching hospital. Int J Che Pharmace Sci 2012; 3:25–30. https://doi.org/10.4103/ijp.ijp_507_17
Fan H, Wang Y, Liu T, Zhang K, Ren J, Li Y, Li J, Wu X, Li X, Niu X. Dual versus mono antiplatelet therapy in mild-to-moderate stroke during hospitalization. Ann Clin Transl Neurol. 2022 Apr; 9(4):506-514. https://doi.org/10.1186/s12883-020-01808-y PMID: 35278046; PMCID: PMC8994979.
Han SR, Yeo SP, Lee MK, Bae YC, Ahn DK. Early Dexamethasone Relieves Trigeminal Neuropathic Pain. Journal of Dental Research. 2010; 89(9):915-920. https://doi.org/10.1177/0022034510374056
Lgbisks T, Joseph O. Drug prescription pattern in a Nigerian tertiary hospital. Trop J Pharm Res 2012; 11:146-52. http://dx.doi.org/10.4314/tjpr.v11i1.19
Hurkacz M, Dobrek L, Wiela-Hojeńska A. Antibiotics and the Nervous System-Which Face of Antibiotic Therapy Is Real, Dr. Jekyll (Neurotoxicity) or Mr. Hyde (Neuroprotection)? Molecules. 2021 Dec 9; 26(24):7456. https://doi.org/10.3390/molecules26247456 PMID: 34946536; PMCID: PMC8708917.
Demoz GT, Kasahun GG, Hagazy K, Woldu G, Wahdey S, Tadesse DB, et al. Prescribing pattern of antibiotics using WHO prescribing indicators among inpatients in Ethiopia: A need for antibiotic stewardship program. Infect Drug Resist 2020; 13:2783-94. https://doi.org/10.2147/idr.s262104
Jain S, Upadhyaya P, Goyal J, Kumar A, Jain P, Seth V, et al. A systematic review of prescription pattern monitoring studies and their effectiveness in promoting rational use of medicines. Perspect Clin Res 2015; 6:86-90. https://doi.org/10.4103/2229-3485.154005
Joshi R, Medhi B, Prakash A, Assessment of prescribing pattern of drugs and completeness of prescriptions as per the World Health Organization prescribing indicators in various Indian tertiary care centers: A multicentric study by Rational Use of Medicines Centers-Indian Council of Medical Research network under National Virtual Centre Clinical Pharmacology activity. Indian J Pharmacol 2022; 54:321-8. https://doi.org/10.4103/ijp.ijp_976_21
Singh UR, Prabhakas S, Ambika A, Roshani S, Bhupendra R, Mishra S. Pharmacoepidemiology of prescribing drug in tertiary care Hospital in Central India; Rewa, Madhya Pradesh in year 2013-14. Int J Res Pharm Biosci 2014; 1:8-14. https://doi.org/10.4103%2Fijp.ijp_976_21
Sharma V, Sharma S, Narwat A et al. Prescribing pattern of various drugs in neurology department at tertiary care hospital in haryana. Int J Health Sci Res. 2017; 7(12):75- 79. https://doi.org/10.4103/ijp.ijp_976_21
Pal A, Gambre R. A cross- sectional observational drug utilisation study of antipsychotic drugs prescribed in patients suffering from psychiatric illnesses at a tertiary care hospital. Int J Basic Clin Pharmacol 2022; 11:446-52. http://dx.doi.org/10.18203/2319-2003.ijbcp20222141
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