Formulation and Evaluation of Buccoadhesive Tablet of Verapamil Hydrochloride for the Treatment of Hypertension

Abstract

The creation and assessment of buccoadhesive tablets of verapamil hydrochloride were the study's primary goals. Blood pushing excessively hard against the arterial wall is referred to as hypertension. Typically, hypertension is characterized by blood pressure readings over 140/90; readings over 180/120 are regarded as severe hypertension. Verapamil is used to manage angina (chest pain) and treat excessive blood pressure. Verapamil belongs to the category of drugs known as calcium channel blockers. In order to save the heart from having to pump as hard, it relaxes the blood artery. Additionally, it enhances the heart's blood and oxygen flow while decreasing electrical activity to regulate heart rate. Five formulations that demonstrated satisfactory physicochemical characteristics and drug release were chosen for the investigation. Physical examination, weight fluctuation, uniformity of content, thickness, friability, hardness, and in vitro drug release were used to characterize the formulation. In terms of physical examination, weight variation, uniformity of content, thickness, friability, hardness, and in vitro drug release, all formulations produce satisfactory results. The buccoadhesive tablet formulation (F2 Batch) had the best in vitro drug release of 87% in 8 hours. Verapamil hydrochloride's UV spectrum was examined, and it was discovered that the drug's highest absorbance occurs at 227nm, increasing its bioavailability.

Keywords: Verapamil Hydrochloride, Hypertension, Bioavailability, Buccoadhesive Tablet, Calcium channel blocker.