Formulation and In-Vitro Evaluation of Gabapentin Loaded Transferosomal Gel
Abstract
Gabapentin is an anticonvulsant which is primarily used to treat peripheral neuropathy. It belongs to class III drugs having High solubility and low permeability. The present study is carried out on formulation and invitro evaluation of Gabapentin Transferosomal gel by using various surfactants, polymers. The Transferosomes were prepared by thin film hydration technique. Different proportions of surfactants have been utilized such as span 80 and tween 80. 8 distinctive formulations of Gabapentin transferosomes had been formulated and evaluated for parameters like FTIR, Organoleptic evaluation, Drug content, Entrapment efficiency, Invitro diffusion studies, SEM, Zeta potential and particle size analysis, pH, Spreadability, Viscosity, Stability testing and Kinetic studies. The optimized formulation Gf6 confirmed Entrapment efficiency of 86.54%, Drug content 96.11% Zeta potential of -31.64Mv, particle size of 164.2nm, In-vitro drug release ranging from (75.15- 89.37%). The drug release data of selected formulation confirmed desirable fit into Zero order and Peppas release Kinetics. Overall, it can be concluded that the transferosomal gel can overcome problems associated with convectional routes of drug delivery.
Keywords: Gabapentin, Transferosomes, Edge activators, Thin film hydration method.
Keywords:
Gabapentin, Transferosomes, Edge activators, Thin film hydration methodDOI
https://doi.org/10.22270/jddt.v13i12.6081References
Archana Pandita, Pooja Sharma, "Pharmacosomes: An Emerging Novel Vesicular Drug Delivery System for Poorly Soluble Synthetic and Herbal Drugs", International Scholarly Research Notices, vol. 2013, Article ID 348186, 10 pages, 2013. https://doi.org/10.1155/2013/348186
Abdulbaqi IM, Darwis Y, Khan NA, Assi RA, Khan AA. Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials. Int J Nanomedicine. 2016 May 25;11:2279-304. doi: https://doi.org/10.2147/IJN.S105016 PMID: 27307730; PMCID: PMC4887071.
Opatha, Shakthi Apsara Thejani, Varin Titapiwatanakun, and Romchat Chutoprapat. 2020. "Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery" Pharmaceutics 12, no. 9: 855. https://doi.org/10.3390/pharmaceutics12090855
Prajapati ST, Patel CG, Patel CN, 'Transferosomes: A Vesicular Carrier System for Transdermal Drug Delivery', Asian Journal of Biochemical and Pharmaceutical Research., 2011; 2(1):507-524. https://doi.org/10.4103/2231-4040.85524
"Taxonomy". International Association for the Study of pain. Archived from the original on 13 January 2015. Retrieved 3 May 2015.
Kaur, Jaskirat; Ghosh, Shampa; Sahani, Asish Kumar; Sinha, Jitendra Kumar. "Mental imagery training for treatment of central neuropathic pain: a narrative review". Acta Neurologica Belgica. 2019;119(2):175–186. https://doi.org/10.1007/s13760-019-01139-x
Derry S, Bell RF, Straube S, Wiffen PJ, Aldington D, Moore RA. Pregabalin for neuropathic pain in adults. Cochrane Database Syst Rev. 2019 Jan 23;1(1):CD007076. DOI: https://doi.org/10.1002/14651858.CD007076.pub3.CD007076.pub3 PMID:30673120;PMCID:PMC6353204.
Wiffen PJ, Derry S, Bell RF, Rice AS, Tölle TR, Phillips T, Moore RA. Gabapentin for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2017 Jun 9;6(6):CD007938. DOI: https://doi.org/10.1002/14651858.CD007938.pub4 . CD007938 .pub4. PMID: 28597471; PMCID: PMC6452908.
Neuropathic pain in adults: pharmacological management in non-specialist settings. London: National Institute for Health and Care Excellence (NICE); 2020 Sep 22. (NICE Clinical Guidelines, No. 173.) Available from: https://www.ncbi.nlm.nih.gov/books/NBK552848/
Karanki P and Kishore B: Formulation and evaluation of lornoxicam transfersomes as carriers for effective transdermal drug delivery. Indian Journal of Research in Pharmacy and Biotechnology 2015; 3(6): 416-2
Chien YW, Banga AK. Iontophoretic (transdermal) delivery of drugs: overview of historical development. J Pharm Sci. 1989 May;78(5):353-4. DOI: https://doi.org/10.1002/jps.2600780502 PMID: 2664122.
Nimker V, Jamal H, Ghosh P, Jain S, Beotra A. LIPOSOMES: DRUG DELIVERY SYSTEM OR POSSIBLE DOPING AGENT?. JDDT. 2017;7(1):25-9. doi: https://jddtonline.info/index.php/jddt/article/view/1369
Thakur N, Jain P, Jain V. FORMULATION DEVELOPMENT AND EVALUATION OF TRANSFEROSOMAL GEL. JDDT. 2018;8(5):168-77. Available from: https://jddtonline.info/index.php/jddt/article/view/1826
Thakur N, Jain P, Jain V. FORMULATION DEVELOPMENT AND EVALUATION OF TRANSFEROSOMAL GEL. JDDT. 15Sep.2018;8(5):168-77. Available from: https://jddtonline.info/index.php/jddt/article/view/1826
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