Implantable Drug Delivery System: An Innovative Approach
Abstract
The conventional routes of drug administration has limited control over drug release and maintaining constant plasma therapeutic drug concentrations for longer periods of time. To avoid these problems associated with utilization of traditional dosage forms, there was essential need for development of new dosage forms which would discharge drugs at controlled rate for local activity. This led to improvement of Novel Drug Delivery Systems (NDDS) that offers optimisation of therapeutic properties of drugs and makes them safer, productive and dependable over traditional ways of administration. Implantable drug delivery system (IDDS) forms a part of novel drug delivery system. This route of administering medications allows targeted distribution, location specificity, constant release rate, low amount of drug requirements, and minimisation of adverse effects with improved efficacy. It provides possibility of administering drugs once weekly to yearly which otherwise previously require frequent daily dosing. Different implantable technologies are currently in use for many therapeutic applications such as in dentistry, ophthalmology, contraception and oncology. However, the expensiveness of this newly improved drug delivery system is quite high which hinders its large scale use. Moreover, the recently developed devices require further enhancement and hence thorough scientific trials are needed before wide implementation in populations.
Keywords: Implantable drug delivery, implants, drug delivery system, implantable pump, modulated drug delivery, novel drug delivery system
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Danckwerts M, Fassihi A, Implantable Controlled Release Drug Delivery Systems: A Review, Drug Development and Industrial Pharmacy, 1991; 17(11): 1465-1502. https://doi.org/10.3109/03639049109026629.
Ms. Aishwarya Sandip Ankaram, Ms Shubhangi Raosaheb Mali, Implantable Polymeric Drug Delivery Devices: Classification, Manufacture and Clinical Applications, International Journal of Research Publication and Reviews, 2022; 3(6): 3200-3205. https://ijrpr.com/uploads/V3ISSUE6/IJRPR5158.pdf.
Saettone MF, Salminen L, Ocular inserts for topical delivery, Advanced Drug Delivery Reviews, 1995; 16(1): 95-106. https://doi.org/10.1016/0169-409X(95)00014-X.
Rajgor N, Patel M, bhaskar VH, implantable drug delivery systems: An overview, systemic reviews in pharmacy, 2011; 2(2): 91-96. https://faculty.ksu.edu.sa/sites/default/files/implantable_drug_delivery_systems_an_overview.pdf. https://doi.org/10.1016/0169-409X(95)00014-X
Chien, Y. W., Lin, S, Optimization of treatment by applying programmable rate-controlled drug delivery technology, Clinical Pharmacokinetics, 2002; 41(15): 1267–1299. https://doi.org/10.2165/00003088-200241150-00003.
Bhowmik, D., Pusupoleti, K. R. Duraivel, S. Kumar, K. S., Recent approaches in transdermal drug delivery system, The Pharma Innovation, 2013; 2(3): 99-108. https://www.thepharmajournal.com/vol2Issue3/Issue_may_2013/3.pdf https://doi.org/10.2165/00003088-200241150-00003
Mohammad Zaki AJ., Satish K. Patil, Dheeraj T. Baviskar1, Dinesh K. Jain, Implantable Drug Delivery System: A Review; International Journal of PharmTech Research, 2012; 4(1): 280-292. https://sphinxsai.com/2012/pharm/PHARM/PT=40(280-292)JM12.pdf
da Silva, G.R. Fialho, S.L. Siqueira, R.C. Jorge, R. Cunha, A.D, Implants as drug delivery devices for the treatment of eye diseases, Brazilian Journal of Pharmaceutical Sciences, 2010; 46(3): 585-595. https://doi.org/10.1590/S1984-82502010000300024
Dr. Aijaz A. Sheikh, Dr. Subhash V. Deshmane, Dr. Md. Rageeb, Md. Usman, Dr. Kailash R. Blyani. A Textbook of Novel Drug Delivery System. 2019 edition. Jalandhar: Pee Vee publication; 2019. P.77. https://doi.org/10.2165/00003088-200241150-00003
Iaes L., Ignatius A, Development of new biodegradable implants, Der Chirurg, 2002; 73:990-996. https://doi.org/10.1007/s00104-002-0543-0
Tian W., Mahmoudi M., Lhermusier T., Kiranmijyan S., Chen F., Torguson R., Suddath W.O., Satler L.F., Pichard A.D., Waksman R., The influence of advancing age on implantation of drug eluting stents, Catheterization and Cardiovascular Interventions, 2015; 88 :516-521 https://doi.org/10.1002/ccd.26333.
Preparation of implants; “Pharma tips”; available at: http://www.pharmatips.in/Articles/Pharmaceutics/Preparation-Of-Implants.aspx. Accessed July 4, 2011.
Kumar A., Pillai J. Nanostructures for the Engineering of Cells, Tissues and Organs. Elsevier. Implantable drug delivery systems, 2018: P. 473–511. https://doi.org/10.1002/ccd.26333
Bourges, J. L., Bloquel, C., Thomas, A.; Froussart, F., Bochot, A., Azan, F., Gurny, R.; BenEzra, D., Behar-Cohen, Intraocular Implants for Extended Drug Delivery: Therapeutic Applications, Advanced Drug Delivery Reviews, 2006; 58: 1182–1202. https://doi.org/10.1016/j.addr.2006.07.026
Wang X, Chen T, Yang Z, Wang W, Study on structural optimum design of implantable drug delivery micro-system, Simulation Modelling Practice and Theory, 2007; 15:47-56. https://doi.org/10.1016/j.simpat.2006.09.017
Kimura H, Ogura Y, Hashizoe M, Nishiwaki H, Honda Y, Ikada Y, A new vitreal drug delivery system using an implantable biodegradable polymeric device, Investigative Ophthalmology and Visual Science, 1994; 35:2815-9. https://iovs.arvojournals.org/article.aspx?articleid=2179750 https://doi.org/10.1016/j.simpat.2006.09.017
Santosh Pradip Bhivsane, Shinde Sonal B, Wamne Vikas B., Review on implantable drug delivery system, International Journal for Research Trends and Innovation , 2022,7(11):380-390. https://www.ijrti.org/papers/IJRTI2211054.pdf
Cao L, Mentell S, Polla D, Design and simulation of an implantable medical drug delivery system using microelectromechanical systems technology, Sensors and Actuators A: Physical, 2001; 94:117-125. https://doi.org/10.1016/S0924-4247(01)00680-X
Renard E, Implantable closed-loop glucose-sensing and insulin delivery: the future for insulin pump therapy, Current Opinion in Pharmacology, 2002; 2:708-716. https://doi.org/10.1016/s1471-4892(02)00216-3
Blackshear PJ, Rhode TH, Artificial devices for insulin infusion in the treatment of patients with diabetes mellitus. In: Burk SD, editor. Controlled Drug Delivery, Clinical Applications. Boca Raton, FL: CRC Press; 1983; 2: 11.
Dash AK, Suryanarayanan R., An implantable dosage form for the treatment of bone infections, Pharmaceutical Research, 1992, 9:993-1002. https://doi.org/10.1023/A:1015842108772
Sefton MV, Implantable pumps, CRC Crit Rev Bioeng, 1987; 14:201-40. https://pubmed.ncbi.nlm.nih.gov/3297487/ https://doi.org/10.1023/A:1015842108772
Wu DQ, Chu CC, biodegradable synthetic hydrophobic-hydrophilic hybrid hydrogels: swelling behaviour and controlled drug release, J Biomater Cci, 2008; 19(4): 411-29. https://pubmed.ncbi.nlm.nih.gov/18318955/
Martin A, Bustamante P, Chun A. Physical pharmacy: Physical Chemical Principles in the Pharmaceutical Sciences. 4th ed. Philadelphia (Pa.): Lea & Febiger, 1993: P. 534-6. https://doi.org/10.1163/156856208783719536
Kutz M. Biomedical Engineering and Design Handbook. Volume 2. McGraw-Hill: New York, USA, 2009:
Gulati K., Kogawa M., Prideaux M., Findlay D.M., Atkins G.J., Losic D, Drug-releasing nano-engineered titanium implants: Therapeutic efficacy in 3D cell culture model, controlled release and stability, Mater. Sci. Eng. C, 2016; 69:831–840. https://pubmed.ncbi.nlm.nih.gov/27612777/ https://doi.org/10.1016/j.msec.2016.07.047
Silvia Ligorio Fialho, Armando da silva Cunha, manufacturing techniques of biodegradable implants intended for intraocular application, drug delivery, 2005; 12(2): 109-116. https://pubmed.ncbi.nlm.nih.gov/15824036/ https://doi.org/10.1080/10717540590921432
Aulton ME, Pharmaceutics: the science of dosage form design. 2nd ed. Philadelphia, PA: Churchill Livingstone, 2005.
Breitenbach, J., Melt extrusion: from process to drug delivery technology, European journal of pharmaceutics and bio pharmaceutics, 2002; 54(2):107- 117. https://doi.org/10.1016/S0939-6411(02)00061-9
Zhou Q, Armstrong B, Larson I, Stewart PJ, Mortan DA, Improving powder flow properties of a cohesive lactose monohydrate powder by intensive mechanical dry coating, J Pharm Sci, 2010; 99:969-81. https://doi.org/10.1002/jps.21885
Jivraj, M., Martini, L.G. and Thomson, C.M., An overview of the different excipients useful for the direct compression of tablets, Pharmaceutical science & technology today, 2000; 3(2):58-63. https://doi.org/10.1016/S1461-5347(99)00237-0
Rothen-Weinhold, A., Besseghir, K., Vuaridel, E., Sublet, E., Oudry, N., Kubel, F. and Gurny, R., Injection-moulding versus extrusion as manufacturing technique for the preparation of biodegradable implants, European journal of pharmaceutics and bio pharmaceutics,1999; 48(2): 113-121. https://pubmed.ncbi.nlm.nih.gov/10469929/ https://doi.org/10.1016/S0939-6411(99)00034-X
Norman, J., Madurawe, R.D., Moore, C.M., Khan, M.A. and Khairuzzaman, A., A new chapter in pharmaceutical manufacturing: 3D-printed drug products, advanced drug delivery reviews, 2017; 108: 39-50. https://doi.org/10.1016/j.addr.2016.03.001
Patel S Taher, SenguptaMukul, Fast Dissolving Pill Technology – A Review. World Journal of Pharmacy and Pharmaceutical Sciences, 2013; 2(2):485-508.
Jameela SR, Kumary TV, Lal AV, Jayakrishnan A, Progesterone-loaded chitosan microspheres: A long acting biodegradable controlled delivery system, J Control Release, 1998; 52(1-2):17-24. https://pubmed.ncbi.nlm.nih.gov/9685932/ https://doi.org/10.1016/S0168-3659(97)00187-9
Islam S, Islam S, Urmi AB, Observation of the release of aspirin from gelatin-sodium alginate polymeric implant, J Chem Pharm Res, 2012; 4(12):5149-56. https://www.jocpr.com/abstract/observation-of-the-release-of-aspirin-from-gelatinsodium-alginate-polymeric-implant-2129.html
Karina CR, Riesta P, Esti H., Preparation and evaluation of ciprofloxacin implants using bovine hydroxyapatite-chitosan composite and glutaraldehyde for osteomyelitis, Int J Pharm Sci ,2016; 8(1):45-51. http://repository.unair.ac.id/86303/3/C-16.pdf
Dharmendra Solanki et al., Ijppr, 2021; 20 (4): 116-132. https://ijppr.humanjournals.com/wp-content/uploads/2020/09/71.Dharmendra-Solanki-Semimul-Akhtar.pdf
Sindhu et al., Asian J Pharm Clin Res, 2017; 10(11): 239-243. https://doi.org/10.22159/ajpcr.2017.v10i11.20070
Colaris MJ, de Boer M, van der Hulst RR, Cohen T JW, Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature, Immunologic Research, 2017; 65(1):120-8. https://pubmed.ncbi.nlm.nih.gov/27406737/ https://doi.org/10.1007/s12026-016-8821-y
Siepmann J, Siepmann F, Modeling of diffusion controlled drug delivery, Journal of Controlled Release, 2012; 161(2):351-62. https://doi.org/10.1016/j.jconrel.2011.10.006
Vyas SP, KharRoop K. Controlled Drug Delivery Concepts and Advances. 1st Ed .Delhi: Vallabh Prakashan; 2008. P. 450-459.
Jain NK. Advances in Controlled & Novel Drug Delivery. 1st Ed. New Delhi: CBS Publication, & Distributors; 2005. P.219-223.
Implantable drug delivery system, Available Online https://nanotechnology-cis.wikispaces.com/file/view/pic%202.gif/379176650/pic%202.gif, accessed 1 May 2016.
Kumar, A.; Pillai, J. Implantable drug delivery systems in nanostructures for the engineering of cells, Tissues and Organs, Elsevier: Amsterdam, The Netherlands, 2018; P. 473–511. https://doi.org/10.1016/B978-0-12-813665-2.00013-2
W.B. Saunders. Robinson’s current therapy in Equine Medicine. 7th Ed.; 2015.
How does it work? [Internet]. 2020 [cited 2023 May 10]. Available from: https://www.alzet.com/products/alzet_pumps/how-does-it-work/
Y. Fu and W. J. Kao, Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems, Expert Opin. Drug De-liv., 2010, 7 (4): P. 429-444. https://pubmed.ncbi.nlm.nih.gov/20331353/ https://doi.org/10.1517/17425241003602259
W. M. Saltzman, Biomedical Engineering: Bridging Medicine and Technology, Cambridge University Press, New York, 2009. https://doi.org/10.1017/CBO9780511802737
Patil H, Feng X, Ye X, Majumdar S, Repka MA, Continuous production of fenofibrate solid lipid nanoparticles by hot-melt extrusion technology: a systematic study based on a quality by design approach, AAPS J, 2015;17(1):194–205. https://pubmed.ncbi.nlm.nih.gov/25344439/ https://doi.org/10.1208/s12248-014-9674-8
Materials engineering [Internet]. 2012 [cited 2023 May 11]. Available from: https://www.substech.com/dokuwiki/doku.php?id=metal_injection_molding
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